<p>*p for differences between the 3 groups derived from one-way analysis of variance (ANOVA) unless otherwise noted.</p>a<p>Chi-square test for the difference between gender.</p>b<p>Change in the International Restless Legs Study Group (IRLSSG) Rating Scale for severity of RLS between baseline and 36 months follow-up: worsening = increase in score by >5 points, unchanged = change in score not more than ±5 points, improving = decrease in score >5 points.</p>c<p>International Restless Legs Study Group Rating Scale for severity of RLS (IRLS).</p
