Braided Oscillators

The braided Hopf algebra structure of the generalized oscillator is investigated. Using the solutions two types of braided Fibonacci oscillators are introduced. This leads to two types of braided Biedenharn-Macfarlane oscillators.Comment: 12 pages, latex, some references added, published versio

A Gauge-Gravity Relation in the One-loop Effective Action

We identify an unusual new gauge-gravity relation: the one-loop effective action for a massive spinor in 2n dimensional AdS space is expressed in terms of precisely the same function [a certain multiple gamma function] as the one-loop effective action for a massive charged scalar in 4n dimensions in a maximally symmetric background electromagnetic field [one for which the eigenvalues of F_{\mu\nu} are maximally degenerate, corresponding in 4 dimensions to a self-dual field, equivalently to a field of definite helicity], subject to the identification F^2 \Lambda, where \Lambda is the gravitational curvature. Since these effective actions generate the low energy limit of all one-loop multi-leg graviton or gauge amplitudes, this implies a nontrivial gauge-gravity relation at the non-perturbative level and at the amplitude level.Comment: 6 page

Numerical Investigation of Monopole Chains

We present numerical results for chains of SU(2) BPS monopoles constructed from Nahm data. The long chain limit reveals an asymmetric behavior transverse to the periodic direction, with the asymmetry becoming more pronounced at shorter separations. This analysis is motivated by a search for semiclassical finite temperature instantons in the 3D SU(2) Georgi-Glashow model, but it appears that in the periodic limit the instanton chains either have logarithmically divergent action or wash themselves out.Comment: 14 pages, 6 figures; v2 minor changes, published versio

New technologies in clinical microbiology

Rapid identification of microorganisms in the clinical microbiology laboratory can be of great value for selection of optimal patient management strategies for infections caused by bacteria, viruses, fungi, mycobac-teria, and parasites. Rapid identification of microorganisms in clinical samples enables expedient de-escala-tion from broad-spectrum agents to targeted antimicrobial therapy. The switch to tailored therapy minimizes risks of antibiotics, namely, disruption of normal flora, toxic side effects, and selective pressure. There is a critical need for new technologies in clinical microbiology, particularly for bloodstream infections, in which associated mortality is among the highest of all infections. Just as importantly, there is a need for the clinical laboratory community to embrace the practices of evidence-based interventional laboratory medicine and collaborate in translational research projects to establish the clinical utility, cost benefit, and impact of new technologies. The topic “new technologies ” described here was part of a group session entitled Clinical Microbiology in the Year 2015, part of the 2011 Camp Clin Micro meeting held in Houston, TX. The discussion focused on new and emerging laboratory methods, specifically those related to identification of blood

Supersymmetric Euler-Heisenberg effective action: Two-loop results

The two-loop Euler-Heisenberg-type effective action for N = 1 supersymmetric QED is computed within the background field approach. The background vector multiplet is chosen to obey the constraints D_\a W_\b = D_{(\a} W_{\b)} = const, but is otherwise completely arbitrary. Technically, this calculation proves to be much more laborious as compared with that carried out in hep-th/0308136 for N = 2 supersymmetric QED, due to a lesser amount of supersymmetry. Similarly to Ritus' analysis for spinor and scalar QED, the two-loop renormalisation is carried out using proper-time cut-off regularisation. A closed-form expression is obtained for the holomorphic sector of the two-loop effective action, which is singled out by imposing a relaxed super self-duality condition.Comment: 27 pages, 2 eps figures, LaTeX; V2: typos corrected, comments and reference adde

QED vacuum fluctuations and induced electric dipole moment of the neutron

Quantum fluctuations in the QED vacuum generate non-linear effects, such as peculiar induced electromagnetic fields. In particular, we show here that an electrically neutral particle, possessing a magnetic dipole moment, develops an induced electric dipole-type moment with unusual angular dependence, when immersed in a quasistatic, constant external electric field. The calculation of this effect is done in the framework of the Euler-Heisenberg effective QED Lagrangian, corresponding to the weak field asymptotic expansion of the effective action to one-loop order. It is argued that the neutron might be a good candidate to probe this signal of non-linearity in QED.Comment: A misprint has been corrected, and three new references have been adde

Experimental conditions to suppress edge localised modes by magnetic perturbations in the ASDEX Upgrade tokamak

Access conditions for full suppression of Edge Localised Modes (ELMs) by Magnetic Perturbations (MP) in low density high confinement mode (H-mode) plasmas are studied in the ASDEX Upgrade tokamak. The main empirical requirements for full ELM suppression in our experiments are: 1. The poloidal spectrum of the MP must be aligned for best plasma response from weakly stable kink-modes, which amplify the perturbation, 2. The plasma edge density must be below a critical value, $3.3 \times 10^{19}$~m$^{-3}$. The edge collisionality is in the range $\nu^*_i = 0.15-0.42$ (ions) and $\nu^*_e = 0.15-0.25$ (electrons). However, our data does not show that the edge collisionality is the critical parameter that governs access to ELM suppression. 3. The pedestal pressure must be kept sufficiently low to avoid destabilisation of small ELMs. This requirement implies a systematic reduction of pedestal pressure of typically 30\% compared to unmitigated ELMy H-mode in otherwise similar plasmas. 4. The edge safety factor $q_{95}$ lies within a certain window. Within the range probed so far, $q_{95}=3.5-4.2$, one such window, $q_{95}=3.57-3.95$ has been identified. Within the range of plasma rotation encountered so far, no apparent threshold of plasma rotation for ELM suppression is found. This includes cases with large cross field electron flow in the entire pedestal region, for which two-fluid MHD models predict that the resistive plasma response to the applied MP is shielded

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.

BACKGROUND: Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies. Praziquantel treatment during pregnancy boosts maternal immune responses to schistosome antigens and reduces worm burden. Effects of praziquantel treatment during pregnancy on responses among offspring are unknown. METHODS: In a trial of anthelminthic treatment during pregnancy in Uganda (ISRCTN32849447; http://www.controlled-trials.com/ISRCTN32849447/elliott), offspring of women with Schistosoma mansoni were examined for cytokine and antibody responses to schistosome worm (SWA) and egg (SEA) antigen, in cord blood and at age one year. Relationships to maternal responses and pre-treatment infection intensities were examined, and responses were compared between the offspring of women who did, or did not receive praziquantel treatment during pregnancy. RESULTS: Of 388 S. mansoni-infected women studied, samples were obtained at age one year from 215 of their infants. Stool examination for S. mansoni eggs was negative for all infants. Cord and infant samples were characterised by very low cytokine production in response to schistosome antigens with the exception of cord IL-10 responses, which were substantial. Cord and infant cytokine responses showed no association with maternal responses. As expected, cord blood levels of immunoglobulin (Ig) G to SWA and SEA were high and correlated with maternal antibodies. However, by age one year IgG levels had waned and were hardly detectable. Praziquantel treatment during pregnancy showed no effect on cytokine responses or antibodies levels to SWA or SEA either in cord blood or at age one year, except for IgG1 to SWA, which was elevated in infants of treated mothers, reflecting maternal levels. There was some evidence that maternal infection intensity was positively associated with cord blood IL-5 and IL-13 responses to SWA, and IL-5 responses to SEA, and that this association was modified by treatment with praziquantel. CONCLUSIONS: Despite strong effects on maternal infection intensity and maternal immune responses, praziquantel treatment of infected women during pregnancy had no effect on anti-schistosome immune responses among offspring by age one year. Whether the treatment will impact upon the offspring's responses on exposure to primary schistosome infection remains to be elucidated. TRIAL REGISTRATION: ISRCTN: ISRCTN32849447

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties.

The tegumental allergen-like (TAL) proteins from Schistosoma mansoni are part of a family of calcium binding proteins found only in parasitic flatworms. These proteins have attracted interest as potential drug or vaccine targets, yet comparatively little is known about their biochemistry. Here, we compared the biochemical properties of three members of this family: SmTAL1 (Sm22.6), SmTAL2 (Sm21.7) and SmTAL3 (Sm20.8). Molecular modelling suggested that, despite similarities in domain organisation, there are differences in the three proteins' structures. SmTAL1 was predicted to have two functional calcium binding sites and SmTAL2 was predicted to have one. Despite the presence of two EF-hand-like structures in SmTAL3, neither was predicted to be functional. These predictions were confirmed by native gel electrophoresis, intrinsic fluorescence and differential scanning fluorimetry: both SmTAL1 and SmTAL2 are able to bind calcium ions reversibly, but SmTAL3 is not. SmTAL1 is also able to interact with manganese, strontium, iron(II) and nickel ions. SmTAL2 has a different ion binding profile interacting with cadmium, manganese, magnesium, strontium and barium ions in addition to calcium. All three proteins form dimers and, in contrast to some Fasciola hepatica proteins from the same family; dimerization is not affected by calcium ions. SmTAL1 interacts with the anti-schistosomal drug praziquantel and the calmodulin antagonists trifluoperazine, chlorpromazine and W7. SmTAL2 interacts only with W7. SmTAL3 interacts with the aforementioned calmodulin antagonists and thiamylal, but not praziquantel. Overall, these data suggest that the proteins have different biochemical properties and thus, most likely, different in vivo functions

Evaluation of a multiplexed bead assay for assessment of Epstein-Barr virus immunologic status

Currently, serological assays using either indirect immunofluorescence assay or enzyme-linked immunosorbent assay (ELISA) are performed to evaluate the status of Epstein-Barr virus (EBV) infection in humans. Although these methods are reliable, they are limited to testing an antibody response to a single viral antigen per reaction, thus necessitating a panel of assays to complete the evaluation. In contrast, a new bead-based method (BioPlex 2200; Bio-Rad Laboratories, Hercules, Calif.) can analyze the humoral response to multiple antigens in a single tube. This approach potentially reduces overall cost, turnaround time, and sample volume. The aim of this study was to evaluate the multiplexed EBV serologic assays performed on the BioPlex 2200 platform compared to results of conventional heterophile and ELISA-based assays. A total of 167 nonconsecutive, stored serum samples from adult and pediatric patients submitted for EBV serologic studies were used in the evaluation. Concordance between results generated by the BioPlex 2200 system and conventional assays was calculated. The anti-EA-D assay had the lowest concordance at 91%. The BioPlex 2200 system showed 97% agreement with conventional heterophile and anti-nuclear antigen assays and 92% agreement with the anti-VCA IgG and immunoglobulin M assays. Agreement between the BioPlex 2200 system and conventional testing was 92% with respect to categorization of acute versus nonacute EBV disease. The correlation between these two systems with regard to assignment into one of four categories of EBV status was also good (82%). In summary, there is excellent correlation between contemporary EBV serologic testing and the BioPlex 2200 system