Evaluation of Overall Survival (OS) and Event-Free Survival (EFS) of paediatric sarcoma patients at a single institution

Aims: To evaluate OS and EFS of paediatric sarcoma patients with an interest in comparing metastatic cases with non-metastatic cases, and compiling statistics on treatment methods. Methods: Information was obtained from patient notes in the Schiehallion ward. These contained information about diagnosis, treatment, prognostic indicators, and outcomes for each patient. Results: 56 patients, 2001-2008. Osteosarcoma: 11 patients, 7♂, 4♀; age range: 4-16; = 10; OS = 64%, EFS = 55%; Primary site of disease: Femur (47%), Tibia (41%), Humerus (5.5%), Scapula (5.5%), Other (1%); Metastatic Rate = 27% (OS = 0%). Ewing’s sarcoma: 24 patients, 10♂, 14♀; age range: 1-16, = 12; OS = 71%, EFS = 58%; Primary site of disease: Pelvis (29%), Femur (22%), Paraspinal (16%), Chest Wall (10%), Tibia (10%), Other (13%); Metastatic Rate = 21% (OS = 40%; EFS = 40%); Alveolar rhabdomyosarcoma: 10 patients; OS= 80%, EFS = 60%; Metastatic Rate = 20% (OS = 100%; EFS = 100%). Embryonal rhabdomyosarcoma: 11 patients; OS = 73%, EFS = 73%; Metastatic Rate = 0%. Conclusions: Our results reflect access to an experienced and innovative paediatric sarcoma service with close links to a national Sarcoma MDT. The data falls in line with other studies in terms of age of onset, location of primary tumour, metastatic rate, site of metastases, and prognosis for all cancer types. Limb salvage surgery is greatly favoured over amputation for both osteosarcoma and Ewing’s sarcoma. Females have a more favourable prognosis in osteosarcoma and a slightly poorer prognosis in Ewing’s sarcoma. Yorkhill’s overall survival rates are currently better than the UK-wide statistic for three of the four tumours examined.</p

Polarized radio emission over the southern Galactic plane at 2.4 GHz

Polarimetric results from the Parkes 2.4-GHz survey of the southern Galactic plane are presented. These take the form of a series of images, detailing the polarized intensity and vector position angles over the survey area. The observations were made using the 64-m Parkes radio telescope, and cover the Galactic plane within the region 238°≤l≤5°, with a latitude range of at least |b|≤5°, with some coverage to b = +7° and b = -8°. The resolution of the images is 10.4 arcmin. The rms noise of the polarized intensity images is 11 mJy beam area-1 (5.3 mK), and the rms variation in the vector position angles is of the order of several dgrees. The images show many polarized structures, over a wide range of intensities and angular sizes. Bright, extended regions of polarized emission (of the order of 5° across) are detected, including the Vela supernova remnant and a large 'cap' structure appearing to the north of Sgr A. A quasi-uniform 'background' component of faint, patchy emission is seen over the length of the survey. This faint component appears to originate over a range of distances, out to greater than 5 kpc, and shows considerable structure in the orientations of the polarization vectors. Several bright H II complexes are seen to exhibit bipolar, depolarizing 'plumes', several degrees in length, which are interpreted as outflows of low-density thermal material (with densities in the range 1-10 cm-3)