54 research outputs found
O uso do Instagram para a Promoção da SaĂșde: Uma Contribuição da ExtensĂŁo UniversitĂĄria
O objetivo deste trabalho foi mostrar o uso do Instagram como ferramenta para promover a extensĂŁo universitĂĄria no contexto da pandemia da Covid-19. O trabalho foi conduzido de forma remota com reuniĂ”es pelo Google Meet e WhatsApp. O pĂșblico-alvo foram os profissionais, professores e estudantes da ĂĄrea da saĂșde e população geral. Foram realizadas duas postagens semanais na forma de folders ou vĂdeos e duas lives no perĂodo de um ano. A conta do projeto na rede Instagram, apĂłs um ano, possuĂa 353 seguidores e 2.003 engajamentos. Foram realizadas 106 publicaçÔes, entre estas 80,2% (85) folders digitais e 19,8% (21) vĂdeos. O principal tema dos folders foi Covid-19, seguido por microrganismos e higiene das mĂŁos. O tema Covid-19 passou a ser o foco das publicaçÔes devido ao contexto da pandemia. No Dia Mundial de Higienização das MĂŁos foi postado um vĂdeo sobre higienização simples das mĂŁos. Devido Ă promoção desta postagem, ela teve 60 engajamentos e alcance de 32.720 perfis. De acordo com as estimativas do Instagram, o pĂșblico do projeto apresenta em sua maioria mulheres 63,4% (224), de 25 a 34 anos, 35,8% (126) e residentes no Brasil 99,3% (351). A rede social Instagram pode estar integrada Ă extensĂŁo universitĂĄria auxiliando na disseminação de informaçÔes de forma confiĂĄvel e levando conhecimento bĂĄsico e tĂ©cnico para o seu pĂșblico. Para aumentar o engajamento e alcance das publicaçÔes seria interessante investimentos em recursos financeiros para promover os conteĂșdos
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients with critical coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the prevalence of these antibodies, their longitudinal dynamics across the disease severity scale, and their functional effects on circulating leukocytes remain unknown. Here, in 284 patients with COVID-19, we found type I IFNâspecific autoantibodies in peripheral blood samples from 19% of patients with critical disease and 6% of patients with severe disease. We found no type I IFN autoantibodies in individuals with moderate disease. Longitudinal profiling of over 600,000 peripheral blood mononuclear cells using multiplexed single-cell epitope and transcriptome sequencing from 54 patients with COVID-19 and 26 nonâCOVID-19 controls revealed a lack of type I IFNâstimulated gene (ISG-I) responses in myeloid cells from patients with critical disease. This was especially evident in dendritic cell populations isolated from patients with critical disease producing type I IFNâspecific autoantibodies. Moreover, we found elevated expression of the inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) on the surface of monocytes isolated from patients with critical disease early in the disease course. LAIR1 expression is inversely correlated with ISG-I expression response in patients with COVID-19 but is not expressed in healthy controls. The deficient ISG-I response observed in patients with critical COVID-19 with and without type I IFNâspecific autoantibodies supports a unifying model for disease pathogenesis involving ISG-I suppression through convergent mechanisms
The Early Evolution of BitingâChewing Performance in Hexapoda
Insects show a plethora of different mandible shapes. It was advocated that these mandible shapes are mainly a function of different feeding habits. This hypothesis was tested on a larger sampling of non-holometabolan bitingâchewing insects with additional tests to understand the interplay of mandible function, feeding guild, and phylogeny. The results show that at the studied systematic level, variation in mandible bitingâchewing effectivity is regulated to a large extent by phylogenetic history and the configuration of the mandible joints rather than the food preference of a given taxon. Additionally, lineages with multiple mandibular joints such as primary wingless hexapods show a wider functional space occupation of mandibular effectivity than dicondylic insects (= silverfish + winged insects) at significantly different evolutionary rates. The evolution and occupation of a comparably narrow functional performance space of dicondylic insects is surprising given the low effectivity values of this food uptake solution. Possible reasons for this relative evolutionary âstasisâ are discussed
Viral to metazoan marine plankton nucleotide sequences from the Tara Oceans expedition
A unique collection of oceanic samples was gathered by the Tara Oceans expeditions (2009-2013), targeting plankton organisms ranging from viruses to metazoans, and providing rich environmental context measurements. Thanks to recent advances in the field of genomics, extensive sequencing has been performed for a deep genomic analysis of this huge collection of samples. A strategy based on different approaches, such as metabarcoding, metagenomics, single-cell genomics and metatranscriptomics, has been chosen for analysis of size-fractionated plankton communities. Here, we provide detailed procedures applied for genomic data generation, from nucleic acids extraction to sequence production, and we describe registries of genomics datasets available at the European Nucleotide Archive (ENA, www.ebi.ac.uk/ena). The association of these metadata to the experimental procedures applied for their generation will help the scientific community to access these data and facilitate their analysis. This paper complements other efforts to provide a full description of experiments and open science resources generated from the Tara Oceans project, further extending their value for the study of the world's planktonic ecosystems
L'éducation à la citoyenneté au prisme du cours d'éducation physique: représentations et pratiques enseignantes
LâĂ©ducation Ă la citoyennetĂ© est au centre des discussions dans beaucoup dâĂ©coles et dans notre sociĂ©tĂ© dĂ©mocratique. Ce mĂ©moire se penche sur le travail des enseignants en Ă©ducation physique afin de cerner leurs reprĂ©sentations et mises en pratique de lâĂ©ducation Ă la citoyennetĂ© dans leur cours. Par le biais de deux groupes de discussion, nous avons interrogĂ© des enseignants dâĂ©coles secondaires de profil diffĂ©rent mais de niveau socio-Ă©conomique proche : lâune est de type gĂ©nĂ©ral, lâautre de type qualifiant. AprĂšs lâobservation sociodĂ©mographique des professeurs, nous avons analysĂ© leur discours et dĂ©taillĂ© les diffĂ©rentes reprĂ©sentations et pratiques considĂ©rĂ©es. Ensuite, nous avons eu la confirmation des thĂ©ories de certains auteurs qui soutiennent que des facteurs comme lâĂąge des professeurs et des Ă©lĂšves ainsi que le contexte dâenseignement exercent une influence sur les reprĂ©sentations. NĂ©anmoins, dans notre contexte dâanalyse, nous avons dĂ©couvert que les pratiques Ă©voluent en fonction du degrĂ© dans lequel les professeurs enseignent mais Ă©galement que lâĂ©ducation Ă la citoyennetĂ© passe au second plan pour les professeurs qui enseignent aux garçons du degrĂ© supĂ©rieur. Enfin, nous nous sommes rendu compte quâun programme des Ă©tudes en Ă©ducation physique de 2014 prĂ©voit le travail de lâĂ©ducation Ă la citoyennetĂ© essentiellement dans le champ de la coopĂ©ration socio-motrice. Or lâĂ©ducation Ă la citoyennetĂ© dĂ©passe largement ce champ. Alors que le programme de lâĂ©ducation Ă la citoyennetĂ© sera dâapplication Ă la rentrĂ©e de septembre 2017, ne faudrait-il pas adapter les programmes dâĂ©ducation physiqueâ? Dans le mĂȘme temps, ne faut-il pas sensibiliser les enseignants Ă lâĂ©ducation Ă la citoyennetĂ© en considĂ©rant lâĂ©lĂšve comme un citoyen Ă lâintĂ©rieur dâune Ă©cole dĂ©mocratiqueâ?Master [120] en sciences de l'Ă©ducation, UniversitĂ© catholique de Louvain, 201
Dual oxidase 1 activity is directly regulated via phosphorylations by the protein kinase A
info:eu-repo/semantics/nonPublishe
Regulation of Duox activities by calcium and phorbol esters
info:eu-repo/semantics/nonPublishe
Congenital hypothyroidism caused by a new mutation in the catalytic site of the H2O2 generating enzyme Duox2
info:eu-repo/semantics/nonPublishe
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