All-optical high speed NOR gate based on two photon absorption in silicon wire waveguides

We demonstrate for the first time an all-optical logic NOR gate in submicron size silicon wire waveguides. High speed operation at equivalent 80Gbps data rate was achieved using pump induced non-degenerate two-photon absorption inside the waveguides. The device requires low pulse energy (few pJ) for logic gate operation. (C) 2005 Optical Society of America

FHIT gene therapy prevents tumor development in Fhit-deficient mice

The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environmental carcinogens. FHIT inactivation and loss of expression is found in a large fraction of premaligant and malignant lesions. In this study, we were able to inhibit tumor development by oral gene transfer, using adenoviral or adenoassociated viral vectors expressing the human FHIT gene, in heterozygous Fhit+/- knockout mice, that are prone to tumor development after carcinogen exposure. We therefore suggest that FHIT gene therapy could be a novel clinical approach not only in treatment of early stages of cancer, but also in prevention of human cancer

A Reduced Order Approach for the Embedded Shifted Boundary FEM and a Heat Exchange System on Parametrized Geometries

A model order reduction technique is combined with an embedded boundary finite element method with a POD-Galerkin strategy. The proposed methodology is applied to parametrized heat transfer problems and we rely on a sufficiently refined shape-regular background mesh to account for parametrized geometries. In particular, the employed embedded boundary element method is the Shifted Boundary Method (SBM), recently proposed in Main and Scovazzi, J Comput Phys [17]. This approach is based on the idea of shifting the location of true boundary conditions to a surrogate boundary, with the goal of avoiding cut cells near the boundary of the computational domain. This combination of methodologies has multiple advantages. In the first place, since the Shifted Boundary Method always relies on the same background mesh, there is no need to update the discretized parametric domain. Secondly, we avoid the treatment of cut cell elements, which usually need particular attention. Thirdly, since the whole background mesh is considered in the reduced basis construction, the SBM allows for a smooth transition of the reduced modes across the immersed domain boundary. The performances of the method are verified in two dimensional heat transfer numerical examples

7370) Waveguides; (190.4180) Multiphoton processes; (200.4560) Optical data processing; (200.3760) Logic-based optical processing

Abstract: We demonstrate for the first time an all-optical logic NOR gate in submicron size silicon wire waveguides. High speed operation at equivalent 80Gbps data rate was achieved using pump induced non-degenerate two-photon absorption inside the waveguides. The device requires low pulse energy (few pJ) for logic gate operation

The Effort of Increasing Reynolds Number in Projection-Based Reduced Order Methods: From Laminar to Turbulent Flows

We present in this double contribution two different reduced order strategies for incompressible parameterized Navier-Stokes equations characterized by varying Reynolds numbers. The first strategy deals with low Reynolds number (laminar flow) and is based on a stabilized finite element method during the offline stage followed by a Galerkin projection on reduced basis spaces generated by a greedy algorithm. The second methodology is based on a full order finite volume discretization. The latter methodology will be used for flows with moderate to high Reynolds number characterized by turbulent patterns. For the treatment of the mentioned turbulent flows at the reduced order level, a new POD-Galerkin approach is proposed. The new approach takes into consideration the contribution of the eddy viscosity also during the online stage and is based on the use of interpolation. The two methodologies are tested on classic benchmark test cases

Analysis of the cytochrome c-dependent apoptosis apparatus in cells from human pancreatic carcinoma

Defects in the apoptotic system are likely to play a role in tumorigenesis. Pancreatic carcinoma cells are extremely resistant to apoptosis induction by chemotherapy suggesting that the apoptosis machinery is faulty. We investigated the integrity of the cytochrome c-dependent apoptotic apparatus in 10 human pancreatic carcinoma cell lines. Expression of Apaf-1, caspase-3, -6, -7, -8 and -9, Hsp-70 and XIAP was detected in all cell lines. The expression levels of Apaf-1 and caspase-8 were homogenous in all cell lines whereas differences in expression of other caspases were seen. In cytosolic fractions, all investigated caspases were processed in response to cytochrome c but the extent of processing varied between the cell lines. No stringent correlation between the amount of processing of caspase-9 and effector caspases was seen. Cytochrome c-induced effector caspase activity was quantitated by enzyme assay. Especially at low concentrations of added cytochrome c, this response varied greatly between the cell lines. These data demonstrate that the apoptotic system downstream of the mitochondria is qualitatively intact in pancreatic carcinoma. They further show that the response to cytochrome c can be quantitated in a cell-free system and that determinants other than mere expression of apoptotic molecules can regulate cytochrome c-induced apoptosis