619 research outputs found

    Alien Registration- Dumaine, Zephirina (Scarborough, Cumberland County)

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    https://digitalmaine.com/alien_docs/20105/thumbnail.jp

    Adapting to New Security Realities in a Climate-Disrupted World

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    On November 26, 2021, Ms. Carol Dumaine, Nonresident Senior Fellow at Atlantic Council, presented Adapting to New Security Realities in a Climate-Disrupted World at the 2021 CASIS West Coast Security Conference. The primary concepts of Ms. Dumaine’s presentation centered on how climate change and the global pandemic are becoming significant issues of national security, and how it is vital that our concept of national security be reframed to understand and address climate change as a security issue. The presentation was followed by a question and answer period and a breakout room session with questions from the audience and CASIS Vancouver executives. &nbsp

    Martin Margiela and the Japanese Designers: An Exploration of Cultural Exchange Through Fashion

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    This paper will explore the exchange of culture and the topic of cultural appropriation. Using the Belgian fashion designer Martin Margiela as a case study, it will discuss the way in which he was inspired by Japanese culture and Issey Miyake, Yohji Yamamoto, and Rei Kawakubo– three Japanese fashion designers who first appeared in Paris in the 1970’s and 80’s

    The Light in Morehead 1920-1930: Allie W. Young

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    A poster describing the formative years of Morehead State Normal School during the 1920s and 1930s. The poster was created by Cody Dumaine and Paige Marshall and titled The Light in Morehead 1920-1930: Allie W. Young.https://scholarworks.moreheadstate.edu/msu_100_years_posters/1002/thumbnail.jp

    Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes

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    The functional trafficking steps used by soluble NSF attachment protein receptor (SNARE) proteins have been difficult to establish because of substantial overlap in subcellular localization and because in vitro SNARE-dependent binding and fusion reactions can be promiscuous. Therefore, to functionally identify the site of action of the vesicle-associated membrane protein (VAMP) family of R-SNAREs, we have taken advantage of the temporal requirements of adipocyte biosynthetic sorting of a dual-tagged GLUT4 reporter (myc-GLUT4-GFP) coupled with small interfering RNA gene silencing. Using this approach, we confirm the requirement of VAMP2 and VAMP7 for insulin and osmotic shock trafficking from the vesicle storage sites, respectively, and fusion with the plasma membrane. Moreover, we identify a requirement for VAMP4 for the initial biosynthetic entry of GLUT4 from the Golgi apparatus into the insulin-responsive vesicle compartment, VAMP8, for plasma membrane endocytosis and VAMP2 for sorting to the specialized insulin-responsive compartment after plasma membrane endocytosis
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