Economic Perspectives on GMO Market Segregation

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The speckled scallop, Argopecten circularis, in Aqua Hedionda Lagoon, San Diego County, California

Speckled scallops, Argopecten circularis (Sowerby, 1835), were sampled at Agua Hedionda Lagoon, Carlsbad, San Diego County from March 1984 to October 1986, to obtain basic life history data. Monthly samples of scallops were collected, measured, and released to obtain length frequency data for estimates of growth, life span, and spawning period. Subsamples of scallops were collected for determination of gonadal-somatic and adductor muscle-somatic indices. In 1984 large concentrations of speckled scallops were found on the sand-silt bottom of the lagoon, closely associated with eelgrass, Zostra marina. During the course of the study the numbers of scallops declined, until their virtual disappearance at the end of 1986. Monthly length frequency plots from 24,375 scallop measurements indicate that this is a rapidly growing species with a short life span. Gonadal- and adductor muscle-somatic indices from subsamples of 1,714 scallops indicate first spawning at age one and a relationship between temperature and spawning. Based on this study management recommendations are made for the speckled scallop. (39pp.

Exploring Relations between Teachers’ Beliefs, Instructional Practices, and Students’ Beliefs in Statistics

We examined the epistemic climate of statistics classrooms across two different classrooms by measuring teachers’ espoused beliefs about teaching statistics and observing their teaching practices. We then explored whether students’ beliefs became more aligned with the epistemic climate of the classroom over time. Post-secondary students’ beliefs were measured at the beginning and end of the semester. To measure the epistemic climate, teachers completed self-reports of their beliefs about teaching and learning, and participated in two semi-structured interviews at the beginning and end of the semester. Moreover, several classroom observations were conducted over the course of the semester. Analyses of the data revealed that for one group of students in one class, their beliefs were well aligned with the classroom climate and remained stable over time whereas for the other group of students, their beliefs shifted over time to align with the classroom climate

Design Analyses of Capillary Burst Valves in Centrifugal Microfluidics

centrifugal force. (a) shows top view of the rotating plate. The reservoir resides at R1 and the abruptly-expanding open is at R2. The reservoir and channel are filled by liquid sample. (b) shows a close-up view of the abruptly-expanding opening. Liquid pressure at the meniscus is Pm

Biogeochemical Analysis of Ancient Pacific Cod Bone Suggests Hg Bioaccumulation was Linked to Paleo Sea Level Rise and Climate Change

Deglaciation at the end of the Pleistocene initiated major changes in ocean circulation and distribution. Within a brief geological time, large areas of land were inundated by sea-level rise and today global sea level is 120 m above its minimum stand during the last glacial maximum. This was the era of modern sea shelf formation; climate change caused coastal plain flooding and created broad continental shelves with innumerable consequences to marine and terrestrial ecosystems and human populations. In Alaska, the Bering Sea nearly doubled in size and stretches of coastline to the south were flooded, with regional variability in the timing and extent of submergence. Here we suggest how past climate change and coastal flooding are linked to mercury bioaccumulation that could have had profound impacts on past human populations and that, under conditions of continued climate warming, may have future impacts. Biogeochemical analysis of total mercury (tHg) and δ13C/δ15N ratios in the bone collagen of archeologically recovered Pacific Cod (Gadus macrocephalus) bone shows high levels of tHg during early/mid-Holocene. This pattern cannot be linked to anthropogenic activity or to food web trophic changes, but may result from natural phenomena such as increases in productivity, carbon supply and coastal flooding driven by glacial melting and sea-level rise. The coastal flooding could have led to increased methylation of Hg in newly submerged terrestrial land and vegetation. Methylmercury is bioaccumulated through aquatic food webs with attendant consequences for the health of fish and their consumers, including people. This is the first study of tHg levels in a marine species from the Gulf of Alaska to provide a time series spanning nearly the entire Holocene and we propose that past coastal flooding resulting from climate change had the potential to input significant quantities of Hg into marine food webs and subsequently to human consumers

Identification of a novel class of autotaxin inhibitors through cross-screening

Three novel series were generated in order to mimic the pharmacophoric features displayed by lead compound AM095, a Lysophosphatidic acid (LPA1) receptor antagonist. Biological evaluation of this array of putative LPA1 antagonists led us to the discovery of three novel series of inhibitors of the ecto-enzyme Autotaxin (ATX), responsible for LPA production in blood, with potencies in the range 1 – 4 μM accompanied with good (> 100 μg/mL) solubility