1,005 research outputs found
Multi-rate data fusion for state and parameter estimation in (Bio-)chemical process engineering
For efficient operation, modern control approaches for biochemical process engineering require information on the states of the process such as temperature, humidity or chemical composition. Those measurement are gathered from a set of sensors which differ with respect to sampling rates and measurement quality. Furthermore, for biochemical processes in particular, analysis of physical samples is necessary, e.g., to infer cellular composition resulting in delayed information. As an alternative for the use of this delayed measurement for control, so-called soft-sensor approaches can be used to fuse delayed multirate measurements with the help of a mathematical process model and provide information on the current state of the process. In this manuscript we present a complete methodology based on cascaded unscented Kalman filters for state estimation from delayed and multi-rate measurements. The approach is demonstrated for two examples, an exothermic chemical reactor and a recently developed model for biopolymer production. The results indicate that the the current state of the systems can be accurately reconstructed and therefore represent a promising tool for further application in advanced model-based control not only of the considered processes but also of related processes
Influence of an immunoglobulin-enriched (IgG, IgA, IgM) solution on activation and immunomodulatory functions of peripheral blood mononuclear cells in a LPS second-hit model
A relativistically covariant version of Bohm's quantum field theory for the scalar field
We give a relativistically covariant, wave-functional formulation of Bohm's
quantum field theory for the scalar field based on a general foliation of
space-time by space-like hypersurfaces. The wave functional, which guides the
evolution of the field, is space-time-foliation independent but the field
itself is not. Hence, in order to have a theory in which the field may be
considered a beable, some extra rule must be given to determine the foliation.
We suggest one such rule based on the eigen vectors of the energy-momentum
tensor of the field itself.Comment: 1 figure. Submitted to J Phys A. 20/05/04 replacement has additional
references and a few minor changes made for clarity. Accepted by J Phys
The Application of Ultrasonics in Non-Destructive Testing: A Review of Some of the Research at University College London
This paper presents a review of some of the research projects at University College London which use ultrasonic waves in non-destructive testing. The projects covered include a low-frequency scanning acoustic microscope, a new dark-field acoustic microscope, an update on finite difference model studies of wave propagation and scattering, developments in mode-conversion techniques for defect characterisation, a new high-resolution acoustic field sampling probe and a resume of the work on Zn0 transducers
Shot noise in lithographically patterned graphene nanoribbons
We have investigated shot noise and conductance of multiterminal graphene nanoribbon devices at temperatures down to 50 mK. Away from the charge neutrality point, we find a Fano factor Fâ0.4, nearly independent of the charge density. Our shot noise results are consistent with theoretical models for disordered graphene ribbons with a dimensionless scattering strength K0 â 10 corresponding to rather strong disorder. Close to charge neutrality, an increase in F up to âŒ0.7 is found, which indicates the presence of a dominant Coulomb gap possibly due to a single quantum dot in the transport gap.Peer reviewe
On the Quantitative Impact of the Schechter-Valle Theorem
We evaluate the Schechter-Valle (Black Box) theorem quantitatively by
considering the most general Lorentz invariant Lagrangian consisting of
point-like operators for neutrinoless double beta decay. It is well known that
the Black Box operators induce Majorana neutrino masses at four-loop level.
This warrants the statement that an observation of neutrinoless double beta
decay guarantees the Majorana nature of neutrinos. We calculate these
radiatively generated masses and find that they are many orders of magnitude
smaller than the observed neutrino masses and splittings. Thus, some lepton
number violating New Physics (which may at tree-level not be related to
neutrino masses) may induce Black Box operators which can explain an observed
rate of neutrinoless double beta decay. Although these operators guarantee
finite Majorana neutrino masses, the smallness of the Black Box contributions
implies that other neutrino mass terms (Dirac or Majorana) must exist. If
neutrino masses have a significant Majorana contribution then this will become
the dominant part of the Black Box operator. However, neutrinos might also be
predominantly Dirac particles, while other lepton number violating New Physics
dominates neutrinoless double beta decay. Translating an observed rate of
neutrinoless double beta decay into neutrino masses would then be completely
misleading. Although the principal statement of the Schechter-Valle theorem
remains valid, we conclude that the Black Box diagram itself generates
radiatively only mass terms which are many orders of magnitude too small to
explain neutrino masses. Therefore, other operators must give the leading
contributions to neutrino masses, which could be of Dirac or Majorana nature.Comment: 18 pages, 4 figures; v2: minor corrections, reference added, matches
journal version; v3: typo corrected, physics result and conclusions unchange
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease
AbstractChronic lung disease remains the major cause of morbidity and mortality of cystic fibrosis (CF) patients. Cftr mutant mice developed severe intestinal obstruction, but did not exhibit the characteristic CF ion transport defects (i.e. deficient cAMP-dependent Clâ secretion and increased Na+ absorption) in the lower airways, and failed to develop CF-like lung disease. These observations led to the generation of transgenic mice with airway-specific overexpression of the epithelial Na+ channel (ENaC) as an alternative approach to mimic CF ion transport pathophysiology in the lung. Studies of the phenotype of ÎČENaC-transgenic mice demonstrated that increased airway Na+ absorption causes airway surface liquid (ASL) depletion, reduced mucus transport and a spontaneous CF-like lung disease with airway mucus obstruction and chronic airway inflammation. Here, we summarize approaches that can be applied for studies of the complex in vivo pathogenesis and preclinical evaluation of novel therapeutic strategies in this model of CF lung disease
Microscopic Derivation of Non-Markovian Thermalization of a Brownian Particle
In this paper, the first microscopic approach to the Brownian motion is
developed in the case where the mass density of the suspending bath is of the
same order of magnitude as that of the Brownian (B) particle. Starting from an
extended Boltzmann equation, which describes correctly the interaction with the
fluid, we derive systematicaly via the multiple time-scale analysis a reduced
equation controlling the thermalization of the B particle, i.e. the relaxation
towards the Maxwell distribution in velocity space. In contradistinction to the
Fokker-Planck equation, the derived new evolution equation is non-local both in
time and in velocity space, owing to correlated recollision events between the
fluid and particle B. In the long-time limit, it describes a non-markovian
generalized Ornstein-Uhlenbeck process. However, in spite of this complex
dynamical behaviour, the Stokes-Einstein law relating the friction and
diffusion coefficients is shown to remain valid. A microscopic expression for
the friction coefficient is derived, which acquires the form of the Stokes law
in the limit where the mean-free in the gas is small compared to the radius of
particle B.Comment: 28 pages, no figure, submitted to Journal of Statistical Physic
Neutrino-less Double Beta Decay and Particle Physics
We review the particle physics aspects of neutrino-less double beta decay.
This process can be mediated by light massive Majorana neutrinos (standard
interpretation) or by something else (non-standard interpretations). The
physics potential of both interpretations is summarized and the consequences of
future measurements or improved limits on the half-life of neutrino-less double
beta decay are discussed. We try to cover all proposed alternative realizations
of the decay, including light sterile neutrinos, supersymmetric or left-right
symmetric theories, Majorons, and other exotic possibilities. Ways to
distinguish the mechanisms from one another are discussed. Experimental and
nuclear physics aspects are also briefly touched, alternative processes to
double beta decay are discussed, and an extensive list of references is
provided.Comment: 96 pages, 38 figures. Published versio
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