Physical and dynamical characterisation of low Delta-V NEA (190491) 2000 FJ10

We investigated the physical properties and dynamical evolution of Near Earth Asteroid (NEA) (190491) 2000 FJ10 in order to assess the suitability of this accessible NEA as a space mission target. Photometry and colour determination were carried out with the 1.54 m Kuiper Telescope and the 10 m Southern African Large Telescope during the object's recent favourable apparition in 2011-12. During the earlier 2008 apparition, a spectrum of the object in the 6000-9000 Angstrom region was obtained with the 4.2 m William Herschel Telescope. Interpretation of the observational results was aided by numerical simulations of 1000 dynamical clones of 2000 FJ10 up to 10^6 yr in the past and in the future. The asteroid's spectrum and colours determined by our observations suggest a taxonomic classification within the S-complex although other classifications (V, D, E, M, P) cannot be ruled out. On this evidence, it is unlikely to be a primitive, relatively unaltered remnant from the early history of the solar system and thus a low priority target for robotic sample return. Our photometry placed a lower bound of 2 hrs to the asteroid's rotation period. Its absolute magnitude was estimated to be 21.54+-0.1 which, for a typical S-complex albedo, translates into a diameter of 130+-20 m. Our dynamical simulations show that it has likely been an Amor for the past 10^5 yr. Although currently not Earth-crossing, it will likely become so during the period 50 - 100 kyr in the future. It may have arrived from the inner or central Main Belt > 1 Myr ago as a former member of a low-inclination S-class asteroid family. Its relatively slow rotation and large size make it a suitable destination for a human mission. We show that ballistic Earth-190491-Earth transfer trajectories with Delta-V < 2 km s^-1 at the asteroid exist between 2052 and 2061.Comment: 2 Tables, 11 Figures, accepted for publication in Astronomy & Astrophysic

Spatial distribution of micrometre‐scale porosity and permeability across the damage zone of a reverse‐reactivated normal fault in a tight sandstone : Insights from the Otway Basin, SE Australia

This research forms part of a PhD project supported by the Australian Research Council [Discovery Project DP160101158] and through an Australian Government Research Training Program Scholarship. Dave Healy acknowledges the support of the Natural Environment Research Council (NERC, UK) through the award NE/N003063/1 ‘Quantifying the Anisotropy of Permeability in Stressed Rock’. This study was also funded by scholarships from the Petroleum Exploration Society of Australia and the Australian Petroleum Production and Exploration Association. We thank Gordon Holm for preparing thin sections and Colin Taylor for carrying out particle size measurements and mercury injection capillary pressure analyses. Aoife McFadden and David Kelsey from Adelaide Microscopy, Braden Morgan, and Sophie Harland are acknowledged for their assistance with laboratory work. Field assistants James Hall, Rowan Hansberry, and Lachlan Furness are also gratefully acknowledged for their assistance with sample collection. Discussions with Ian Duddy on the mineralogy of the Eumeralla Formation are also greatly appreciated. This forms TRaX record 416.Peer reviewedPublisher PD

PENGELOALAAN SDM UNTUK PENGEMBANGAN WISATA GOA GUDAWANG

Pengabdian Kepada Masyarakat ini bertujuan untuk membantu mengembangkan wisata Goa Gudawang dari segi manajemen kususnya pengelolaan SDM. Permasalahan yang diangkat mengenai pengelolaan SDM wisata Goa Gudawang adalah kurangnya SDM yang professional sehingga tujuan organisasi sulit dicapai. Metode pelaksanaan pengabdian ini dilakukan dalam beberapa kegiatan yaitu (a). Tahap Persiapan meliputi : (1). Survey awal (2) Pemantapan dan penentuan lokasi sasaran, (3). Penyusunan bahan/materi pelatihan. Hasil kegiatan ini sangat bermanfaat bagi pengelola wisata Goa Gudawang dalam menambah wawasan serta pengetahuan mengenai manajemen strategi.Kata Kunci: Manajemen SDM, Pengelol

RANCANG BANGUN SISTEM INFORMASI TERINTEGRASI AUDIOVISUAL UNTUK OSCE (OBJECTIVE STRUCTURED CLINICAL EXAMINATION)

Sistem Informasi menjadi penunjang di era modern, termasuk di dunia medis dalam bidang pendidikan kedokteran. Dalam pendidikan kedokteran, Sistem Informasi  digunakan dalam membantu kelancaran pendidikan kedokteran, baik untuk pengajaran, pengujian hingga penilaian. Metoda pengujian dalam Pendidikan kedokteran salah satunya adalah OSCE (Objective Structured Clinical Examination). Pelaksanaan OSCE membutuhkan sumber daya yang besar. Sistem Informasi diintegrasikan dengan sistem audio visual diterapkan untuk meningkatkan efisiensi sumber dayanya didesain untuk pelaksanaan OCSE di fakultas Kedokteran Unswagati. Kemudian desain yang dibuat diujicobakan dalam lingkup sendiri dengan harapan bahwa penerapan Sistem Informasi terintegrasi audiovisual, menjadikan pelaksanaan OSCE  reliabel, valid dan efisie

RIPK3-mediated cell death is involved in DUX4-mediated toxicity in facioscapulohumeral dystrophy

BACKGROUND: Facioscapulohumeral dystrophy (FSHD) is caused by mutations leading to the aberrant expression of the DUX4 transcription factor in muscles. DUX4 was proposed to induce cell death, but the involvement of different death pathways is still discussed. A possible pro-apoptotic role of DUX4 was proposed, but as FSHD muscles are characterized by necrosis and inflammatory infiltrates, non-apoptotic pathways may be also involved. METHODS: We explored DUX4-mediated cell death by focusing on the role of one regulated necrosis pathway called necroptosis, which is regulated by RIPK3. We investigated the effect of necroptosis on cell death in vitro and in vivo experiments using RIPK3 inhibitors and a RIPK3-deficient transgenic mouse model. RESULTS: We showed in vitro that DUX4 expression causes a caspase-independent and RIPK3-mediated cell death in both myoblasts and myotubes. In vivo, RIPK3-deficient animals present improved body and muscle weights, a reduction of the aberrant activation of the DUX4 network genes, and an improvement of muscle histology. CONCLUSIONS: These results provide evidence for a role of RIPK3 in DUX4-mediated cell death and open new avenues of research

The value of rapid functional assays of germline p53 status in LFS and LFL families

We have tested two rapid assays of p53 function, namely the apoptotic assay and the FASAY as means of detecting germline p53 mutations in members of Li–Fraumeni and Li–Fraumeni-like families. Results of the functional assays have been compared with direct sequencing of all 11 exons of the p53 gene. The results show good agreement between the two functional assays and between them and sequencing. No false-positives or negatives were seen with either functional assay although the apoptotic assay gave one borderline result for an individual without a mutation. As an initial screen the apoptotic assay is not only rapid but inexpensive and very simple to perform. It would be expected to detect any germline defect that leads to loss of p53 function. The apoptotic assay could be ideal as a means of prescreening large numbers of samples and identifying those that require further investigation. The FASAY detects mutations in exons 4–10, is rapid and distinguishes between functionally important and silent mutations. © 2000 Cancer Research Campaig

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.

Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid-β peptide (Aβ), as well as 2) neurofibrillary tangles composed of aggregates of hyperphosporylated tau. Elevations in the concentrations of the Aβ42 peptide in the brain, as a result of either increased production or decreased clearance, are postulated to initiate and drive the AD pathologic process. We initially introduced a novel class of bridged aromatics referred tγ-secretase modulatoro as γ-secretase modulators that inhibited the production of the Aβ42 peptide and to a lesser degree the Aβ40 peptide while concomitantly increasing the production of the carboxyl-truncated Aβ38 and Aβ37 peptides. These modulators potently lower Aβ42 levels without inhibiting the γ-secretase-mediated proteolysis of Notch or causing accumulation of carboxyl-terminal fragments of APP. In this study, we report a large number of pharmacological studies and early assessment of toxicology characterizing a highly potent γ-secretase modulator (GSM), (S)-N-(1-(4-fluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine (BPN-15606). BPN-15606 displayed the ability to significantly lower Aβ42 levels in the central nervous system of rats and mice at doses as low as 5-10 mg/kg, significantly reduce Aβ neuritic plaque load in an AD transgenic mouse model, and significantly reduce levels of insoluble Aβ42 and pThr181 tau in a three-dimensional human neural cell culture model. Results from repeat-dose toxicity studies in rats and dose escalation/repeat-dose toxicity studies in nonhuman primates have designated this GSM for 28-day Investigational New Drug-enabling good laboratory practice studies and positioned it as a candidate for human clinical trials