Intervención léxico semántica del lenguaje en usuario con Diagnóstico de Trastorno por Déficit de Atención con Hiperactividad como estrategia para el desarrollo del vocabulario

The acquisition of communicative and linguistic skills by human beings is a complex activity, very different from what the population generally thinks. For proper communication development to take place, numerous structures and processes that occur in the individual since their formation, and throughout their growth, from early ages must intervene. It is important to mention, in the first place, that multiple factors can affect this development, such as the Attention Deficit Hyperactivity Disorder, which is comorbid with communication disorders, since they share linguistic characteristics, and both They belong to neurodevelopmental disorders. Secondly, the role that the family and the school play in the development of the individual, the stimulation that he receives from early ages and the early detection of linguistic difficulties, will benefit the adequate development of the user in the different levels of learning that goes away. to face The development of language components such as the semantic lexicon for vocabulary development, in early school ages is essential for the development of a dialogic language, coherence of speech, social interaction, in short, for the development of social skills that they will allow the individual to relate significantly to adults and their peers. However, it is very common, that the linguistic difficulties present in individuals with Attention Deficit Hyperactivity Disorder go unnoticed causing frustration, discouragement, poor academic performance and in the worst case school dropout, since a difficulty in language not attended to in time, will generate learning difficulties that will mark the individual in training and in their processes of acquisition of reading and writing.La adquisición de habilidades comunicativas y lingüísticas por los seres humanos es una actividad compleja, muy diferente a como piensa generalmente la población. Para que se realice un adecuado desarrollo comunicativo, deben intervenir numerosas estructuras y procesos que se dan en el individuo desde su formación, y a lo largo de su crecimiento, desde edades iniciales. Es importante mencionar, en primer lugar, que múltiples factores pueden afectar dicho desarrollo, como lo es el caso del Trastorno por Déficit de Atención con Hiperactividad, el mismo que guarda comorbilidad con los trastornos de la comunicación, ya que comparten características lingüísticas, y ambos pertenecen a los trastornos del neurodesarrollo. En segundo lugar, el papel que juega la familia y la escuela en el desenvolvimiento del individuo, la estimulación que este reciba desde edades iniciales y la detección temprana de dificultades lingüísticas, beneficiarán el adecuado desarrollo del usuario en los diferentes niveles de aprendizaje que se vaya a enfrentar. El desarrollo de los componentes del lenguaje como lo es el léxico semántico para el desarrollo del vocabulario, en edades escolares iniciales es básico para el desarrollo de un lenguaje dialógico, coherencia del discurso, interacción social, en fin, para el desarrollo de habilidades sociales que le permitirán al individuo relacionarse significativamente con los adultos y sus pares. No obstante, resulta muy habitual, que las dificultades lingüísticas presentes en los individuos con Trastorno por déficit de Atención con Hiperactividad pasen desapercibidas ocasionando frustración, desánimo, bajo rendimiento académico y en el peor de los casos la deserción escolar, ya que una dificultad en el lenguaje no atendida a tiempo, generará dificultades de aprendizaje que marcarán al individuo en formación y en sus procesos de adquisición de la lectura y escritura

Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study.

IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients. Here, we analysed extended follow-up data from IFN-K-treated patients, in order to evaluate persistence of neutralizing anti-IFNα Abs antibodies (Abs), and gene expression profiling. Serum and whole blood RNA samples were obtained in IFN-K-treated patients included in the follow-up study, in order to determine binding and neutralizing anti-IFNα Ab titres, and perform high-throughput transcriptomic studies. Neutralization studies of 13 IFNα subtypes demonstrated the polyclonal nature of the Ab response induced by IFN-K. Follow-up analyses in six patients confirmed a significant correlation between neutralizing anti-IFNα Ab titres and decrease in IFN scores compared to baseline. These analyses also revealed an inhibitory effect of IFNα blockade on the expression of B cell associated transcripts. IFN-K induces a polyclonal anti-IFNα response that decreases IFN- and B cell-associated transcripts. ClinicalTrials.gov, clinicaltrials.gov, NCT01058343

Power losses in thick steel laminations with hysteresis

Magnetic power losses have been experimentally investigated and theoretically predicted over a range of frequencies (direct current—1.5 kHz) and peak inductions (0.5-1.5 T) in 1‐mm‐thick FeSi 2 wt. % laminations. The direct current hysteresis properties of the system are described by the Preisach model, with the Preisach distribution function reconstructed from the measurement of the recoil magnetization curve (Bp=1.7 T). On this basis, the time behavior of the magnetic induction vs frequency at different lamination depths is calculated by a finite element method numerical solution of Maxwell equations, which takes explicitly into account the Preisach model hysteretic B(H) relationship. The computed loop shapes are, in general, in good agreement with the measured ones. The power loss dependence on frequency is predicted and experimentally found to change from a ∼f3/2 to a ∼f2 law with increasing peak induction

TERMINAL FLOWER-1/CENTRORADIALIS inhibits tuberization via protein interaction with the tuberigen activation complex

This work was funded by the Scottish Government Rural and Environment Science and Analytical Services Division as part of the Strategic Research Programme 2016-2021, by a GCRF Foundation Awards for Global Agricultural and Food Systems Research funded by the BBSRC project BB/P022553/1 and also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement number 835704. Research in Prat’s lab was funded by the Spanish Ministerio de Economía y Competitividad BIO2015-73019-EXP, and the aligned Japan EIG CONCERT (PIA102017-1) projects.Potato tuber formation is a secondary developmental program by which cells in the subapical stolon region divide and radially expand, to further differentiate into starch accumulating parenchyma. Whilst some details of the molecular pathway that signals tuberization are known, important gaps in our knowledge persist. Here the role of a member of the TERMINAL FLOWER 1/ CENTRORADIALIS gene family (termed StCEN ) in the negative control of tuberization is demonstrated for the first time. It is shown that reduced expression of StCEN accelerates tuber formation whereas transgenic lines over‐expressing this gene display delayed tuberization and reduced tuber yield. Protein‐protein interaction studies (yeast two hybrid and bimolecular fluorescence complementation) demonstrate that StCEN binds components of the recently described tuberigen activation complex. Using transient transactivation assays we show that the StSP6A tuberization signal is an activation target of the tuberigen activation complex, and that co‐expression of StCEN blocks StFD‐Like‐1 activation of the StSP6A gene. Transcriptomic analysis of transgenic lines mis‐expressing StCEN identify early transcriptional events in tuber formation. These results demonstrate that StCEN suppresses tuberization by directly antagonizing StSP6A function in stolons, identifying StCEN as a breeding marker to improve tuber initiation and yield, through the selection of genotypes with reduced StCEN expression.Publisher PDFPeer reviewe

Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes

Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malignant hyperthermia, central core disease, multiminicore disease and certain centronuclear myopathies. In addition, aberrant skeletal muscle calcium handling is believed to play a pivotal role in the highly prevalent disorder of Thoroughbred racehorses, known as Recurrent Exertional Rhabdomyolysis. Traditionally, such defects were studied in human and equine subjects by examining the contractile responses of biopsied muscle strips exposed to caffeine, a potent RYR1 agonist. However, this test is not widely available and, due to its invasive nature, is potentially less suitable for valuable animals in training or in the human paediatric setting. Furthermore, increasingly, RYR1 gene polymorphisms (of unknown pathogenicity and significance) are being identified through next generation sequencing projects. Consequently, we have investigated a less invasive test that can be used to study calcium homeostasis in cultured, skin-derived fibroblasts that are converted to the muscle lineage by viral transduction with a MyoD (myogenic differentiation 1) transgene. Similar models have been utilised to examine calcium homeostasis in human patient cells, however, to date, there has been no detailed assessment of the cells’ calcium homeostasis, and in particular, the responses to agonists and antagonists of RYR1. Here we describe experiments conducted to assess calcium handling of the cells and examine responses to treatment with dantrolene, a drug commonly used for prophylaxis of recurrent exertional rhabdomyolysis in horses and malignant hyperthermia in humans