Application of reliability design methods to Donghae harbor breakwater

Reliability design methods have been developed for breakwater designs since the mid-1980s. The reliability design method is classified into three categories depending on the level of probabilistic concepts being employed, i.e., Level 1, 2, and 3 methods. Each method gives results in different forms, but all of them can be expressed in terms of probability of failure so that the difference can be compared among the different methods. In this study, we apply the reliability design methods to the stability of armor blocks and sliding of caissons of the breakwater of Donghae Harbor located in the east coast of Korea, which was constructed by traditional deterministic design methods to be damaged in 1987 and reinforced in 1991. Analyses are made for the breakwaters before the damage and after the reinforcement. The allowable probability of failure of a Tetrapod armor layer of 50 years lifetime is proposed as 40% for existing stability formulas, whilst that for caisson sliding as 20% with the failure criterion for the cumulative sliding distance over the lifetime of 0.1 m. The probability of failure before the damage is much higher than the allowable value for both stability of armor blocks and sliding of caissons, indicating that the breakwater was under-designed. The probability of failure for the reinforced breakwater is lower than the allowable value, indicating that the breakwater became stable after the reinforcement. On the other hand, the results of different reliability design methods were in fairly good agreement, confirming that there is not much difference among the different methods.author's final versio

Calculation of partial safety factors of breakwater armor stones considering correlation between wave height and wave steepness

author's final versionIn the calculation of partial safety factors of breakwater armor stones, it has been assumed that all the design variables are independent one another. However, some of them are not independent but are correlated each other. In the present study, the partial safety factors are calculated by considering the correlation between wave height and wave steepness. Smaller partial safety factors and smaller armor weight are obtained if the correlation is taken into account. The reduction becomes prominent as the probability of failure decreases (or the design armor weight increases). The correlation between wave height and steepness in real sea is also estimated by using the wave hindcasting data along the Korean coast

Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia

SummaryBackgroundThe peripheral eosinophil count (PEC) tends to increase during the course of acute eosinophilic pneumonia (AEP), and an initially elevated PEC is associated with milder disease. However, there is a lack of data regarding these phenomena and inflammatory process of AEP.MethodsWe prospectively evaluated serial changes in serum interleukin (IL)-5 levels and the correlation between the initial level of IL-5 and the PEC to investigate whether the initial PEC indicates a resolving state of inflammation. We also evaluated serum tryptase levels to investigate the possibility of involvement of mast cell activity in AEP.ResultsTwenty-one AEP patients were included, and all patients improved within 10 days after corticosteroid treatment. The median initial serum IL-5 level among all patients was 561.0 pg/mL, which decreased to zero at 10 days of follow-up (n = 15, P < 0.001). The median initial serum tryptase level (detectable in 20 of 21 patients) was 3.7 ng/mL and decreased to a median of 1.1 ng/mL at 10 days of follow-up (n = 15, P < 0.001). The initial serum IL-5 and C-reactive protein levels were positively correlated (P = 0.009, r = 0.556), and the initial serum IL-5 level was inversely correlated with the initial PEC (P = 0.004, r = −0.603).ConclusionsOur data suggest that IL-5 is an important cytokine involved in the recruitment of eosinophils from peripheral blood into the lungs, that an initially elevated PEC is associated with a resolving state of inflammation, and that mast cells are potentially involved in the inflammatory process of AEP

Plant Location Selection for Food Production by Considering the Regional and Seasonal Supply Vulnerability of Raw Materials

A production capacity analysis considering market demand and raw materials is very important to design a new plant. However, in the food processing industry, the supply uncertainty of raw materials is very high, depending on the production site and the harvest season, and further, it is not straightforward to analyze too complex food production systems by using an analytical optimization model. For these reasons, this study presents a simulation-based decision support model to select the right location for a new food processing plant. We first define three supply vulnerability factors from the standpoint of regional as well as seasonal instability and present an assessment method for supply vulnerability based on fuzzy quantification. The evaluated vulnerability scores are then converted into raw material supply variations for food production simulation to predict the quarterly production volume of a new food processing plant. The proposed selection procedure is illustrated using a case study of semiprocessed kimchi production. The best plant location is proposed where we can reduce and mitigate risks when supplying raw material, thereby producing a target production volume steadily

Clinical disease characteristics according to karyotype in Turner syndrome

Purpose : Turner syndrome (TS) is a disorder in which various anomalies can be accompanied, especially cardiovascular, renal, thyroid and auditory problems. The aim of this study is to identify the incidence of these disorders in patients with TS according to karyotype. Methods : We reviewed medical records of 90 patients with TS diagnosed by chromosomal analysis in 4 hospitals from Jan 1998 to Dec 2007. We evaluated these cases by prepared protocol of 4 medical problems. Results : The distribution of karyotype was 45,X (47.8&#37;), mosaic pattern (34.4&#37;) and structural aberration group (17.8 &#37;). Renal anomalies, cardiovascular anomalies, thyroid disorders and auditory problems are accompanied in 4.4&#37;, 10.0 &#37;, 11.1&#37; and 5.6&#37;, respectively. 45,X group had renal anomalies (7.0&#37;), cardiovascular anomalies (18.6&#37;), thyroid disorders (9.3&#37;) and auditory problems (11.6&#37;). Mosaic group had renal anomalies (3.2&#37;), thyroid disorders (12.9&#37;), no cardiovascular anomalies and auditory problems. Structural aberration group had cardiovascular anomalies (6.3&#37;), thyroid disorders (12.5&#37;) and no other 2 problems. Patients with 45,X group had a significant higher incidence of cardiovascular anomalies (P&#61;0.025). Conclusion : Our results indicate that there are differences clinically according to karyotype of TS, especially in incidence of cardiovascular anomalies