SUBJETIVIDADE E ESPAÇO: UM OLHAR PELA TEORIA ATOR-REDE

O presente trabalho é uma reflexão teórica sobre uma maneira não moderna de conceituar a subjetividade. Por esse viés, os humanos não são os únicos responsáveis pela construção de sua subjetividade, mas também os ambientes e os elementos não humanos. Para isso, são utilizados como referenciais teóricos Bruno Latour, David Lapoujade, Gabriel Tarde e John Law. Desenvolvemos ainda, a noção de uma ciência barroca, que lida com certas questões epistemológicas de maneira diferente do que uma ciência tradicional, além de se exigir outra postura ético-política dos pesquisadores. A noção de subjetividade, a partir desse percurso epistemológico-metodológico, deve ser apreendida como linhas ou campos de interesse e afetação interagindo num lugar e momento que não se reduzem a sujeitos individuais egocêntricos

Cidade, patrimônio e favela no Rio de Janeiro

The present paper discuss the new museological and museum practices in the city of Rio de Janeiro, as follows: o Museu de Favela Cantagalo Pavão-Pavãozinho; a Galeria Providência; e o Museu Nami. For the theoretical foundation we use Michel de Certeau. We also analyse how this experiences are lined by non orthodox theories of heritage, museums and memory. In this sense, we consider that the entry of new actors in the scene with an active voice about their stories and experiences creates new power dynamics, new models and new initiatives that sometimes escape tradicional models already estabilished and contribute to the fluid dynamics of heritage and memory. We also observe the will of the favelas to show themselves as a constituent part of the city. The paper merge empirical data and the theorical work of Sociomuseology

Infrared singularities of QCD scattering amplitudes in the Regge limit to all orders

Scattering amplitudes of partons in QCD contain infrared divergences which can be resummed to all orders in terms of an anomalous dimension. Independently, in the limit of high-energy forward scattering, large logarithms of the energy can be resummed using Balitsky-Fadin-Kuraev-Lipatov theory. We use the latter to analyze the infrared-singular part of amplitudes to all orders in perturbation theory and to next-to-leading-logarithm accuracy in the high-energy limit, resumming the two-Reggeon contribution. Remarkably, we find a closed form for the infrared-singular part, predicting the Regge limit of the soft anomalous dimension to any loop order.Comment: 35 pages, 8 figure

Narrativas de grafite e expressividade subalterna na pós-modernidade

Este trabalho visa explorar as maneiras pelas quais os grafites se enquadram nos modos de narração e construção de laços de sociabilidade e memória na pós-modernidade. Na esteira do pensamento de autores de filiação pós-moderna, voluntária ou não, propõe-se analisar as narrativas fragmentárias nas quais prevalecem histórias locais de grupos antes vistos como subalternos. Com um acesso ampliado às tecnologias de comunicação, parece haver uma emergência de vozes outrora silenciadas sob o status quo oficial, com uma crescente variedade de visões de mundo de tais grupos na pós-modernidade. A disseminação dessas vozes não mais favorece a história como um conjunto de fatos concretos estabelecidos por um saber legítimo, mas como um número de fábulas que animam uma renovada expressividade subalterna

Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile

The process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic diversification is still ongoing and has very recently led to the emergence of a new variant of concern (VOC), defined as Omicron or B.1.1.529. Omicron VOC is the most divergent variant identified so far and has generated immediate concern for its potential capability to increase SARS-CoV-2 transmissibility and, more worryingly, to escape therapeutic and vaccine-induced antibodies. Nevertheless, a clear definition of the Omicron VOC mutational spectrum is still missing. Herein, we provide a comprehensive definition and functional characterization (in terms of infectivity and/or antigenicity) of mutations characterizing the Omicron VOC. In particular, 887,475 SARS-CoV-2 Omicron VOC whole-genome sequences were retrieved from the GISAID database and used to precisely define its specific patterns of mutations across the different viral proteins. In addition, the functional characterization of Omicron VOC spike mutations was finely discussed according to published manuscripts. Lastly, residues characterizing the Omicron VOC and the previous four VOCs (Alpha, Beta, Gamma, and Delta) were mapped on the three-dimensional structure of the SARS-CoV-2 spike protein to assess their localization in the different spike domains. Overall, our study will assist with deciphering the Omicron VOC mutational profile and will shed more light on its clinical implications. This is critical considering that Omicron VOC is currently the predominant variant worldwide. IMPORTANCE The Omicron variant of concern (VOC) has a peculiar spectrum of mutations characterized by the acquisition of mutations or deletions rarely detected in previously identified variants, particularly in the spike glycoprotein. Such mutations, mostly residing in the receptor-binding domain, could play a pivotal role in enhancing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity (by increasing binding affinity for ACE2), jeopardizing spike recognition by therapeutic and vaccine-induced antibodies and causing diagnostic assay failure. To our knowledge, this is one of the first exhaustive descriptions of newly emerged mutations underlying the Omicron VOC and its biological and clinical implications

Long-acting combination of cabotegravir plus rilpivirine: A picture of potential eligible and ineligible HIV-positive individuals from the Italian ARCA cohort

Objectives: We aimed to evaluate the prevalence and characteristics of people living with HIV (PLWH) eligible for the long-acting injectable (LAI) regimen with cabotegravir (CAB) and rilpivirine (RPV), in comparison with ineligible individuals. Methods: This was an observational, cross-sectional study from the ARCA cohort, including virologically suppressed PLWH with at least one genotypic resistance testing (GRT) for reverse transcriptase and integrase from plasma and/or PBMCs. Eligibility criteria for LAI CAB+RPV were: negative HBsAg, absence of previous virological failures and/or resistance-associated mutations for non-nucleoside reverse transcriptase inhibitors (NNRTIs) and/or integrase strand transfer inhibitors. Potential differences between eligible and ineligible individuals were investigated by univariable and multivariable analyses. Results: A total of 514 individuals were included: 377 (73.3%) were male, median age was 51 (IQR: 43–58), on ART for 9 years (IQR: 4–17), virologically suppressed for 63 months (IQR: 35–105). Eligible individuals for CAB+RPV were 229 (44.5%, 95%CI: 40.8–48.8); compared with ineligible individuals, they received a lower number of previous regimens (aOR 0.76, 95% CI 0.71–0.83, P < 0.001) and were on current NNRTIs (aOR 2.16, 95% CI 1.38–3.37, P = 0.001). Conclusions: Less than half of virologically suppressed PLWH in the ARCA cohort were potentially eligible for CAB+RPV. They seem to be “less complicated” with shorter exposure to ART and preferably already on NNRTIs

Two-parton scattering in the high-energy limit

Considering $2\to 2$ gauge-theory scattering with general colour in the high-energy limit, we compute the Regge-cut contribution to three loops through next-to-next-to-leading high-energy logarithms (NNLL) in the signature-odd sector. Our formalism is based on using the non-linear Balitsky-JIMWLK rapidity evolution equation to derive an effective Hamiltonian acting on states with a fixed number of Reggeized gluons. A new effect occurring first at NNLL is mixing between states with $k$ and $k+2$ Reggeized gluons due non-diagonal terms in this Hamiltonian. Our results are consistent with a recent determination of the infrared structure of scattering amplitudes at three loops, as well as a computation of $2\to 2$ gluon scattering in ${\cal N}=4$ super Yang-Mills theory. Combining the latter with our Regge-cut calculation we extract the three-loop Regge trajectory in this theory. Our results open the way to predict high-energy logarithms through NNLL at higher-loop orders.Comment: 62 pages, 7 figure