Some Practical Laboratory Aspects of Forensic Alcohol Determinations

Determination of ethyl alcohol in human biological material is the most common forsenic chemical examination, the majority of such determinations being performed in connection with investigations to establish the presence or absence of alcoholic influence in operators of motor vehicles. Utilization of alcohol determinations by law enforcement agencies in the United States continues to increase rapidly as demonstrated by an increase of 220% in the number of cities employing chemical tests for alcoholic influence during the last 4 years1. Twenty-three states now have chemical test legislation. Because of the rapidly expanding employment of forensic alcohol determinations, it seemed pertinent to examine some practical laboratory aspects of such tests in the light of our experience with approximately 25,000 such examinations during the past ten years

Drug-use Testing: Scientific Perspectives

Through a coalescence of various events and interests during the past fifteen years, a massive public concern in nonmedical drug-use has developed, resulting in increasingly widespread and large-scale drug-use testing in the United States

Federal Aviation Administration

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Effects of Fluid Load on Human Urine Characteristics Related to Workplace Drug Testing

During workplace drug testing, urine is tested for dilution, substitution and adulteration. Donors argue that these findings are due to medical, health or working conditions or diet and genetic differences. There is a paucity of data correlating changes in urine characteristics after a fluid load to various body parameters. Therefore, five urine specimens (one in the morning, one prior to drinking 800 mL of a beverage, and three time intervals thereafter) from 12 males and 12 females were tested for four different beverages on separate occasions. Of the 480 samples, 376 were in sufficient amounts. Of these 376, 36 (10%) had creatinine 1.0010. Thus, these 27 samples can be considered to be dilute; 20 (74%) of 27 were from females. For males with at least one dilute sample, body fat was 11% less and resting metabolic rate (RMR) was 29% more than males with no dilute samples (p > 0.05); for females with at least one dilute sample, height was 8% less and weight 20% less than females with no dilute samples (p > 0.05). Individuals with a higher RMR appear to have a greater potential for producing dilute urine specimens than those with a lower RMR. Thus, a dilute sample does not necessarily indicate that it was intentionally diluted. Such samples must be carefully evaluated in consideration with recent consumption of liquid by donors to avoid false accusations