Applied problems of physical education students of economic specialties

Purpose : to analyze the problems of physical education students of economics in the context of professionally applied physical training. Material : analysis of Ukrainian and foreign publications on species means of improving professional-applied physical training of students in higher education. Results : It was found that the state system of physical education students is ineffective. It does not provide psychophysical and professional readiness of graduates for productive activities and later life. The system also needs constant improvement. A new approach to solving the problem of training to learn the adoption of practical importance of physical education. Also the formation of motivation by demonstrating a real need and usefulness of the proposed exercise. Such exercises should be differentiated, taking into account the health status and subsequent career expectations. Conclusion: it is proved that for an efficient system of training is necessary to use popular among students sports. It is also necessary to take into account the interests of students when choosing tools professionally applied physical training

The Use of Plasmapheresis in Treatment of Patients with Infertility, Peritoneal Endometriosis and Nat2 Gene Polymorphism

It is known that 30–40 % of patients with peritoneal endometriosis suffer from infertility. Half of the patients with endometriosis are identified point mutation in NAT2 – gene, which plays an important role in the acetylation of aromatic and heterocyclic amines, in the accumulation of endotoxins, activation of free radical oxidation, impaired microcirculation. These factors involve the use of methods of gemapheresis which have detoxification, the blood rheology corrective and immune corrective effects. The purpose of this study was to evaluate the efficacy of therapeutic plasma exchange in treatment of patients with peritoneal form of endometriosis, infertility and point mutations in the gene NAT2. The study included 140 patients with infertility, peritoneal form of endometriosis and point mutations in the gene NAT2. All patients are performed laparoscopy, coagulation foci of endometriosis. In the following 93 (66.4 %) patients were treated with a the course of therapeutic plasmapheresis using the apparatus «PCS-2» with the removal of 20–25 % the volume of circulating plasma with replacement plasma of crystalloid and colloid solutions. Before treatment were shown the signs of endotoxemia, activation of oxidative stress. After treatment with the use of plasmapheresis was revealed the significant reduction of endogenous intoxication parameters and oxidative stress. Also is noted the increase in the pregnancy rate, both independently and in IVF programs, especially during the first 3 months after treatment. The findings suggest that the efficiency of the proposed comprehensive treatment techniques (laparoscopy and subsequent course of therapeutic plasmapheresis) of patients with peritoneal endometriosis and infertility and with point mutations in the gene NAT2. The use of plasmapheresis is pathogenetically justified in patients of the studied group

THE USE OF PLASMAPHERESIS IN TREATMENT OF PATIENTS WITH INFERTILITY, PERITONEAL ENDOMETRIOSIS AND NAT2 GENE POLYMORPHISM

It is known that 30–40 % of patients with peritoneal endometriosis suffer from infertility. Half of the patients with endometriosis are identified point mutation in NAT2 – gene, which plays an important role in the acetylation of aromatic and heterocyclic amines, in the accumulation of endotoxins, activation of free radical oxidation, impaired microcirculation. These factors involve the use of methods of gemapheresis which have detoxification, the blood rheology corrective and immune corrective effects.The purpose of this study was to evaluate the efficacy of therapeutic plasma exchange in treatment of patients with peritoneal form of endometriosis, infertility and point mutations in the gene NAT2.The study included 140 patients with infertility, peritoneal form of endometriosis and point mutations in the gene NAT2. All patients are performed laparoscopy, coagulation foci of endometriosis. In the following 93 (66.4 %) patients were treated with a the course of therapeutic plasmapheresis using the apparatus «PCS-2» with the removal of 20–25 % the volume of circulating plasma with replacement plasma of crystalloid and colloid solutions. Before treatment were shown the signs of endotoxemia, activation of oxidative stress. After treatment with the use of plasmapheresis was revealed the significant reduction of endogenous intoxication parameters and oxidative stress. Also is noted the increase in the pregnancy rate, both independently and in IVF programs, especially during the first 3 months after treatment. The findings suggest that the efficiency of the proposed comprehensive treatment techniques (laparoscopy and subsequent course of therapeutic plasmapheresis) of patients with peritoneal endometriosis and infertility and with point mutations in the gene NAT2. The use of plasmapheresis is pathogenetically justified in patients of the studied group

Estimation of the interdependence of time series of stocks prices based on copula

The relationships in the stock markets, the impact on them of the structural changes in the economy, the ability to adequately forecast for a certain period are investigated. The analysis of the interdependence of stock prices by using copula functions is carried out. The statistical estimations of copulas on a lattice with a step 0.1 are constructed. The distances in the metric L1 from the empirical copula to the maximum (comonotonic), minimum (countermonotonic) and independent copulas are comparedstocks; copula function; comonotonicity; countermonotonicity; independence of random values

N-acetyltransferase 2 (NAT2) Gene Polymorphisms and the Effectiveness of Infertility Treatment in Patients with Peritoneal Endometriosis

Today, infertility has become a global issue. WHO ranks it the fifth among the major diseases of those below 60 years, after alcoholism, depression, injuries and eyesight disorders. Numerous studies conducted on the problems of infertility in endometriosis still do not offer clear answers regarding the pathogenesis and mechanisms of this disease and its influences on fertility. According to the survey results, point mutations of the NAT2 gene (NAT2*5 and NAT2*6) have been identified in 75.6% of the patients with infertility problems and the peritoneal form of endometriosis, that create “slow” allelic variants, which exceed the average index in the population. The peculiarities of the NAT2 gene polymorphisms have been proven to be associated with the effectiveness of the infertility treatment of female patients with peritoneal endometriosis. In the group of non-pregnant patients, the presence of с.341Т>C, c.481C>T, c.590G>A and c.803A>G heterozygous point mutations are 73.2, 73.2, 5.4, and 62.5%, respectively. The significant difference in the comparison of the allelic polymorphism during the various stages of the endometriosis was not identified. At stage III-IV endometriosis the frequency of three and more point substitutions was significantly higher. NAT2 gene polymorphisms can find use as an additional criterion for predicting the effectiveness of the infertility treatment of patients with peritoneal endometriosis

The Study of Microelement Composition of the Spiral Organ’s Cells in Experimental Sensorineural Hearing Loss

Purpose: Studied microelements composition of the spiral organ’s cells in experimental sensorineural hearing loss.Materials and Methods: The X-ray microanalyses of the spiral organ of 15 rats were performed.Results: The 10 experimental animals with sensorineural hearing loss showed changes in trace element content compared with controls.Summary: The greatest improvements were observed in relation to the share of calcium in experimental sensorineural hearing loss

РОЛЬ ГЕНЕТИЧЕСКИХ ФАКТОРОВ, СИСТЕМЫ ДЕТОКСИКАЦИИ И ОКСИДАТИВНОГО СТРЕССА ПРИ ЭНДОМЕТРИОЗЕ И БЕСПЛОДИИ (ОБЗОР ЛИТЕРАТУРЫ)

The aim of this paper is to provide a systematic review of the role of the genetic factors, detoxication systems and oxidative stress in the pathogenesis of endometriosis and infertility. Endometriosis and infertility are still both the most uncommon diseases in gynecology. Many aspects of female reproductive function are strongly influenced by genetic factors, and numerous studies have attempted to identify susceptibility genes for disorders affecting female fertility such as polycystic ovary syndrome, endometriosis, fibroids, cancer (ovarian, vulvar, cervical), premature ovarian failure, recurrent pregnancy loss and pre-eclampsia. The most solid evidence linking specific polymorphisms to endometriosis is showed by the studies investigating a phase II detoxification enzyme. No data were found concerning influences of the genetic factors on the female infertility. Contrary, a lot of studies devoted to the genetic factors of male infertility are presented. It’s known that endometriosis associated with increased systemic oxidative stress. The implication of increased systemic oxidative stress in disease progression or the association with other oxidative stress-related pathologic conditions needs to be addressed in further studies. The majority of studies suggest a reduced antioxidant capacity in infertile women with endometriosis. In the present review we discussed the role of the genetic factors in the pathogenesis of endometriosis and infertility. NAT2 polimorphism, xenobiotic methabolism and exogenous factors are somehow related with these diseases. An altered balance between pro-oxidant and antioxidant activities may have an impact on folliculogenesis and adequate embryo development. Целью работы был обзор литературных данных, связанных с изучением роли генетических факторов, системы детоксикации и оксидативного стресса в патогенезе эндометриоза и бесплодия, которые остаются одними из самых неизученных заболеваний в гинекологии. Взаимосвязь между полиморфизмом генов и различными заболеваниями доказана уже давно. В зарубежных исследованиях подтверждены факты наличия полиморфизма генов при поликистозе яичников, эндометриозе, миоме матки, раке яичников и шейки матки, преждевременном истощении яичников, привычном невынашивании и преэклампсии. Существенным доказательством наличия специфического полиморфизма при эндометриозе с позиций доказательной медицины являются нарушения в системе генов второй фазы детоксикации. В зарубежной литературе представлены исследования, подтверждающие наличие генетических причин при формировании мужских факторов бесплодия. Генетические аспекты женского бесплодия как заболевания не изучены. Роль оксидативного стресса при эндометриозе доказана на основании изучения специфических маркеров. Оксидантный-антиоксидантный статус и активность ферментов, метаболизирующих ксенобиотики, взаимосвязаны и могут меняться в зависимости от воздействия факторов внешней среды. Анализ литературных данных демонстрирует, что развитие эндометриоза и бесплодия предопределяется генетически. Немаловажную роль при этом играют факторы внешней среды и уровень эндогенной интоксикации, определяемый в т.ч. скоростью метаболизма ксенобиотиков. Изменение баланса оксидантной-антиоксидантной системы на системном и локальном уровне приводят к нарушениям функций женской репродуктивной системы (снижение фертильности).

Awareness, Clinical Experience and Knowledge of Female Genital Mutilation/Cutting Among Female Pelvic Medicine and Reconstructive Surgeons in the United States

ObjectiveTo promote the recognition and care of patients with female genital mutilation/cutting (FGM/C), we aimed to evaluate the awareness, clinical experience and knowledge of FGM/C among female pelvic medicine and reconstructive surgery (FPMRS) specialists. FGM/C is a cultural practice whereby there is removal of external female genitalia for non-therapeutic reasons. Despite the high prevalence of urogynecologic complications, there is a paucity of literature discussing FGM/C from the lens of urologists and urogynecologists.MethodsBy cross-sectional design, we distributed a 27-item survey via email to members of the Society of Urodynamics, Female Pelvic Medicine and Reconstructive Surgery. We collected variables pertaining to previous FGM/C education, clinical confidence, cultural and medical knowledge, and desire for future education.ResultsA total of 54 US-based, mostly urologists and FPMRS specialists, completed the survey. All providers had heard of FGM/C; however only 13% received formal education during medical training. Over 50% had encountered a patient with FGM/C in clinical practice. Only 19% and 13% felt completely confident recognizing and discussing FGM/C, respectively. Seventy percent believed religious doctrine informed FGM/C practice and 24% correctly identified FGM/C type on clinical representation. Finally, only 17% of respondents were aware of FGM/C guidelines, and providers expressed a desire for increased availability of multimodal resources.ConclusionEducation regarding FGM/C remains sparse and variable for US FPMRS specialists. Cultural and clinical knowledge is also lacking, which is a detriment to patient care. In order to strengthen awareness and knowledge, we must develop high-quality FGM/C educational resources for urologists and gynecologists

Negative magneto-resistance of electron gas in a quantum well with parabolic potential

We have studied the electrical conductivity of the electron gas in parallel electric and magnetic fields directed along the plane of a parabolic quantum well (across the profile of the potential). We found a general expression for the electrical conductivity applicable for any magnitudes of the magnetic field and the degree of degeneration of the electron gas. A new mechanism of generation of the negative magnetoresistance has been revealed. It has been shown that in a parabolic quantum well with a non-degenerated electron gas the negative magnetoresistance results from spin splitting of the levels of the size quantization.Comment: 15 pages, 3 figure