Plasma cholesterol levels and brain development in preterm newborns.

BackgroundTo assess whether postnatal plasma cholesterol levels are associated with microstructural and macrostructural regional brain development in preterm newborns.MethodsSixty preterm newborns (born 24-32 weeks gestational age) were assessed using MRI studies soon after birth and again at term-equivalent age. Blood samples were obtained within 7 days of each MRI scan to analyze for plasma cholesterol and lathosterol (a marker of endogenous cholesterol synthesis) levels. Outcomes were assessed at 3 years using the Bayley Scales of Infant Development, Third Edition.ResultsEarly plasma lathosterol levels were associated with increased axial and radial diffusivities and increased volume of the subcortical white matter. Early plasma cholesterol levels were associated with increased volume of the cerebellum. Early plasma lathosterol levels were associated with a 2-point decrease in motor scores at 3 years.ConclusionsHigher early endogenous cholesterol synthesis is associated with worse microstructural measures and larger volumes in the subcortical white matter that may signify regional edema and worse motor outcomes. Higher early cholesterol is associated with improved cerebellar volumes. Further work is needed to better understand how the balance of cholesterol supply and endogenous synthesis impacts preterm brain development, especially if these may be modifiable factors to improve outcomes

Integrated optimization of electric bus scheduling and charging planning incorporating flexible charging and timetable shifting strategies

In a battery electric bus (BEB) network, buses are scheduled to perform timetabled trips while satisfying time, energy consumption, charging, and operational constraints. Increasing research efforts have been dedicated to the integrated optimization of multiple planning tasks to reduce system costs. At a high integration level, this study determines the BEB scheduling and charging planning with flexible charging and timetable shifting strategies. We first formulate an integrated arc-based model to minimize the total costs considering the power grid pressure cost and subsequently reformulate it into a two-stage model, for which we develop an effective solution method. The first stage minimizes the total operational costs including the fleet, charging, and battery degradation costs based on the column generation technique, and the second stage minimizes the peak power demand through two timetable shifting strategies. It is found through numerical experiments that the proposed integrated optimization model and solution method can achieve significant improvement in the utilization rate and reductions in the fleet size, operational costs, and peak power demand compared to the two baseline models

A green approach for the synthesis of π conjugated phosphonium salts under visible-light irradiation using air as oxidant

We have developed a strategy for synthesizing π-conjugated phosphonium salts through visible-light-induced cyclization of aryl phosphines in the presence of air and protonic acid. The mechanism study revealed that this C−H bond activation/cyclization of aryl phosphine reaction was initiated from the homolysis of P-H bond of phosphonium salts, which is induced by visible light. This reaction is transition metal free, exhibits good chemo-selectivity and has a high atomic economy

Reforming mixed operation schedule for electric buses and traditional fuel buses by an optimal framework

Bus scheduling plays a significant role in public transportation and supports the sustainable development of transportation systems. Challenges are beginning to appear with the newly emerging electric buses (EBs), as scheduling changes due to fleet composition make traditional fixed timetables no longer able to satisfy operational needs. Moreover, the fixed-trip time hypothesis has been inappropriate for large cities due to the variety of urban traffic statuses. This paper proposes an optimal framework for reforming the mixed operation schedule for electric buses and traditional fuel buses under stochastic trip times. Based on the primary grouping genetic algorithm (GGA), a straightforward framework with a Monte Carlo simulation is presented to optimize the scheduling scheme. Case studies based on the operating environment and service trips of real bus lines in Beijing are conducted to verify the effectiveness of the proposed model by considering both the composition of fleet types and time stochasticity. Additionally, the impacts of stochasticity, fleet composition, government subsidies and cost factors on operational costs are investigated. Considering stochastic trip times, the achieved scheduling strategies can provide the optimal proportion of electric and traditional fuel buses and make a crucial impact on operational costs

Research on the Properties of Zein, Soy Protein Isolate, and Wheat Gluten Protein-Based Films Containing Cellulose Nanocrystals

Plant protein films are a research hotpot in the current food packaging field for their renewable and bio-compatibility, and further improving the physicochemical properties of plant protein films in combination with biodegradable materials is of great significance. In this study, we selected cellulose nanocrystals (CNC) to modify the protein films with soybean protein isolate (SPI), wheat gluten protein (WGP), and Zein, and the physicochemical properties were studied. The results showed that the hardness and opacity of Zein-based films decreased by 16.61% and 54.12% with the incorporation of CNC, respectively. The SPI-based films performed with lower hardness and higher tensile strength. The thickness and opacity of WGP-based films increased by 39.76% and 214.38% after combination with CNC, respectively. Accordingly, this study showed that CNC could largely modify the physicochemical properties of the plant protein films, which provided a reference for the preparation of modified plant protein films using biodegradable materials

Research on the Construction Method of Double Prevention Mechanism in Chinese Heating Enterprises Based on Bidirectional Dynamic Risk-Hidden Danger Transmission

The heating industries are extremely dispersed in China, and most heating enterprises are small in scale, poor in foundation, and chaotic in safety management. The construction method of the double prevention mechanism of heating enterprises in China was analyzed and studied based on the PDCA cycle model and the improved risk assessment method for operating conditions. The analytic hierarchy process was used to determine the weight of dangerous and harmful factors and corresponding control measures for an accident type. The concept of “failure frequency” was introduced, and the calculation method of accident probability (L) was modified so that the accurate hierarchical control and dynamic risk assessment of accident risks can be realized. At the same time, the failure of control measures is defined as “hidden danger” in this paper. Finally, the bidirectional dynamic transmission mechanism of hidden danger investigation and treatment and risk hierarchical control was established. The main problems existing in the construction of double prevention mechanism of heating enterprises in China were discussed and some countermeasures and suggestions were put forward. According to the above methods and steps, the double prevention mechanism of heating enterprises can be reasonably established. Thus, the risks can be effectively identified, the hidden dangers can be controlled, and the safety production of heating enterprises can be guaranteed

Preparation, Application and Enhancement Dyeing Properties of ZnO Nanoparticles in Silk Fabrics Dyed with Natural Dyes

In this study, ZnO nanoparticles were prepared by a hydrothermal method with varying the reaction times, material ratios and reaction temperatures. The samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray Diffraction (XRD) and Fourier infrared spectroscopy (FTIR). It was shown that the material ratio significantly affected the structure and morphology of the synthesized ZnO nanoparticles, and then the uneven nano-octahedral structure, uniform nano-octahedral structure, nano-tubular structure, and nano-sheet structure could be obtained successively. The synthesized ZnO nanoparticles as mordant were used for the dyeing of silk fabrics with different natural dyes (tea polyphenols and hematoxylin). Moreover, they could improve the dyeing properties and fastness (wash and light) on silk fabrics to a certain extent

RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response

Abstract The E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-associated gene 2 (BCA2), has been linked with the growth of some cancers and immune regulation, which is negatively correlated with prognosis. Here, it is demonstrated that the RNF115 deletion can protect mice from acute liver injury (ALI) induced by the treatment of lipopolysaccharide (LPS)/D-galactosamine (D-GalN), as evidenced by decreased levels of alanine aminotransaminase, aspartate transaminase, inflammatory cytokines (e.g., tumor necrosis factor α and interleukin-6), chemokines (e.g., MCP1/CCL2) and inflammatory cell (e.g., monocytes and neutrophils) infiltration. Moreover, it was found that the autophagy activity in Rnf115 −/− livers was increased, which resulted in the removal of damaged mitochondria and hepatocyte apoptosis. However, the administration of adeno-associated virus Rnf115 or autophagy inhibitor 3-MA impaired autophagy and aggravated liver injury in Rnf115 −/− mice with ALI. Further experiments proved that RNF115 interacts with LC3B, downregulates LC3B protein levels and cell autophagy. Additionally, Rnf115 deletion inhibited M1 type macrophage activation via NF-κB and Jnk signaling pathways. Elimination of macrophages narrowed the difference in liver damage between Rnf115 +/+ and Rnf115 −/− mice, indicating that macrophages were linked in the ALI induced by LPS/D-GalN. Collectively, for the first time, we have proved that Rnf115 inactivation ameliorated LPS/D-GalN-induced ALI in mice by promoting autophagy and attenuating inflammatory responses. This study provides new evidence for the involvement of autophagy mechanisms in the protection against acute liver injury