66,191 research outputs found

    Quantum correlations and Nash equilibria of a bi-matrix game

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    Playing a symmetric bi-matrix game is usually physically implemented by sharing pairs of 'objects' between two players. A new setting is proposed that explicitly shows effects of quantum correlations between the pairs on the structure of payoff relations and the 'solutions' of the game. The setting allows a re-expression of the game such that the players play the classical game when their moves are performed on pairs of objects having correlations that satisfy the Bell's inequalities. If players receive pairs having quantum correlations the resulting game cannot be considered another classical symmetric bi-matrix game. Also the Nash equilibria of the game are found to be decided by the nature of the correlations.Comment: minor correction

    Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine.

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    Children with aggressive neural tumors have poor survival rates and novel therapies are needed. Previous studies have identified nifurtimox and buthionine sulfoximine (BSO) as effective agents in children with neuroblastoma and medulloblastoma. We hypothesized that nifurtimox would be effective against other neural tumor cells and would be synergistic with BSO. We determined neural tumor cell viability before and after treatment with nifurtimox using MTT assays. Assays for DNA ladder formation and poly-ADP ribose polymerase (PARP) cleavage were performed to measure the induction of apoptosis after nifurtimox treatment. Inhibition of intracellular signaling was measured by Western blot analysis of treated and untreated cells. Tumor cells were then treated with combinations of nifurtimox and BSO and evaluated for viability using MTT assays. All neural tumor cell lines were sensitive to nifurtimox, and IC50 values ranged from approximately 20 to 210 μM. Nifurtimox treatment inhibited ERK phosphorylation and induced apoptosis in tumor cells. Furthermore, the combination of nifurtimox and BSO demonstrated significant synergistic efficacy in all tested cell lines. Additional preclinical and clinical studies of the combination of nifurtimox and BSO in patients with neural tumors are warranted

    Toolbox value creation final report (WP-101)

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    This document contains the deliverables of TransForum project WP-101, Toolbox Value Creation. Its contents allow users to use a summary analysis toolbox made for charting and improving value chains in the areas of People, Planet and Profit. Features of the toolbox are: Guidance in organizing a quick scan and change process. Create summary graphic overview of the materials balance of a production network. Model People and Planet and Profit separately but in conjunction. Allow flexible inclusion or omission of actors, processes and products. Analyze value of improvements

    Toolbox Value Creation Handbook : Charting People, Planet and Profit in Value Chains

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    To create a sustainable society companies need new data and information regarding e.g. environmental and societal impacts of new products or processes are necessary, but these are often missing. Information systems can play an important role here and many tools are already developed. It became clear that one crucial tool was lacking: One that (a) integrates People, Planet, and Profit value (b) focuses on the whole production chains and (c) allows flexible data input. A new tool, QChain, was born. QChain is meant for anybody who works on sustainability issues, aiming to create a sustainable production chain. In practice this will often be policy makers, champions, consultants and network coordinators that work on a sustainability problem or valorisation issues. The tool is especially useful in organizations that feel the need or want to create the need to not only focus on profit, but also reckon with people and planet value – their licence to produce. QChain is a drawing tool that supports shared value creation for sustainable production chains

    The Kinematics of CIV in Star-Forming Galaxies at z~1.2

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    We present the first statistical sample of rest-frame far-UV spectra of star-forming galaxies at z~1. These spectra are unique in that they cover the high-ionization CIV{\lambda}{\lambda}1548, 1550 doublet. We also detect low-ionization features such as SiII{\lambda}1527, FeII{\lambda}1608, AlII{\lambda}1670, NiII{\lambda}{\lambda}1741, 1751 and SiII{\lambda}1808, and intermediate-ionization features from AlIII{\lambda}{\lambda}1854, 1862. Comparing the properties of absorption lines of lower- and higher- ionization states provides a window into the multi-phase nature of circumgalactic gas. Our sample is drawn from the DEEP2 survey and spans the redshift range 1.01 < z < 1.35 ( = 1.25). By isolating the interstellar CIV absorption from the stellar P-Cygni wind profile we find that 69% of the CIV profiles are blueshifted with respect to the systemic velocity. Furthermore, CIV shows a small but significant blueshift relative to FeII (offset of the best-fit linear regression -76 ±\pm 26 km/s). At the same time, the CIV blueshift is on average comparable to that of MgII{\lambda}{\lambda}2796, 2803. At this point, in explaining the larger blueshift of CIV absorption at the ~ 3-sigma level, we cannot distinguish between the faster motion of highly-ionized gas relative to gas traced by FeII, and filling in on the red side from resonant CIV emission. We investigate how far-UV interstellar absorption kinematics correlate with other galaxy properties using stacked spectra. These stacking results show a direct link between CIV absorption and the current SFR, though we only observe small velocity differences among different ionization states tracing the outflowing ISM.Comment: 21 pages, 14 figures, ApJ, accepte
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