Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts

Bone loss is caused by the dysregulated activity of osteoclasts which degrade the extracellular bone matrix. The tyrosine kinase Pyk2 is highly expressed in osteoclasts, and mice lacking Pyk2 exhibit an increase in bone mass, in part due to impairment of osteoclast function. Pyk2 is activated by phosphorylation at Y402 following integrin activation, but the mechanisms leading to Pyk2 dephosphorylation are poorly understood. In the current study, we examined the mechanism of action of the dynamin GTPase on Pyk2 dephosphorylation. Our studies reveal a novel mechanism for the interaction of Pyk2 with dynamin, which involves the binding of Pyk2's FERM domain with dynamin's plextrin homology domain. In addition, we demonstrate that the dephosphorylation of Pyk2 requires dynamin's GTPase activity and is mediated by the tyrosine phosphatase PTP-PEST. The dephosphorylation of Pyk2 by dynamin and PTP-PEST may be critical for terminating outside-in integrin signaling, and for stabilizing cytoskeletal reorganization during osteoclast bone resorption

Mass-concentration relation of clusters of galaxies from CFHTLenS

Based on weak lensing data from the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS), in this paper we study the mass-concentration ($M$-$c$) relation for $\sim 200$ redMaPPer clusters in the fields. We extract the $M$-$c$ relation by measuring the density profiles of individual clusters instead of using stacked weak lensing signals. By performing Monte Carlo simulations, we demonstrate that although the signal-to-noise ratio for each individual cluster is low, the unbiased $M$-$c$ relation can still be reliably derived from a large sample of clusters by carefully taking into account the impacts of shape noise, cluster center offset, dilution effect from member or foreground galaxies, and the projection effect. Our results show that within error bars the derived $M$-$c$ relation for redMaPPer clusters is in agreement with simulation predictions. There is a weak deviation in that the halo concentrations calibrated by Monte Carlo simulations are somewhat higher than that predicted from ${\it Planck}$ cosmology.Comment: Accepted for Publication in ApJ. 18 pages, 8 figures. Updated to match the published versio

Infant's sex, birth control policy and postpartum well-being: a prospective cohort study in Shanghai, China

Objectives: The Chinese government loosed its birth control policy and allowed the parents to have the second child if both of the parent were from one-child family from 2001. We explore the association between infant’s sex and mother’s postpartum well-being, which may be moderated by birth control policy status in China. Setting and Participants: We conducted a prospective cohort study in Shanghai City, one of the largest cities in China. A total number of 1730 childbearing women from 8 obstetric hospitals across Shanghai were included in the study at baseline, with 1503 women completing the survey 7 days postpartum in 2013. Measures: The General Well-Being Schedule (GWBS) was used to assess maternal well-being at baseline and follow-up investigation in the study. Women’s demographic, clinical characteristic, and well-being were measured at baseline. The maternal satisfaction and postpartum well-being were assessed in the follow-up survey. Results The results of multivariable linear regression analyses showed that women who gave birth to male infants were positively associated with the total score of maternal well-being, when the participated hospitals, maternal well-being at baseline, the socio-demographic characteristic, maternal and infant’s health outcome were added to the adjustments (β=1.462, P0.05). The results of multiple logistic regression model showed that having a male infant was a protective factor of ‘positive well-being’ (OR=0.622, P0.05). Conclusions: Our results emphasize the importance in conducting intervention to increase the general well-being, especially for those with a female infant in a son preference society such as China, and enhance the necessity of sustainability of newly relaxed two-child policy which allows more couples to have the second child in China

Synthesis of Fluorocyclotriphosphazene Derivatives and Their Fire-Retardant Finishing on Cotton Fabrics

A series of novel fire-retardant agents, fluorocyclotriphosphazene derivatives with the substitution groups of 2,2,3,3-tetrafluoropropoxy groups were synthesized using hexachlorocyclotriphosphazene and 2,2,3,3-tetrafluoropropyl alcohol as starting materials. The synthesized fire-retardant agent was emulsified and applied on the cotton fabric finishing to reduce the flammability and afford water/oil repellency simultaneously. The optimum finishing process was achieved according to the test of cotton finishing with fluorocyclotriphosphazene. The treated cotton showed not only excellent fire-retardant performance, but also water and oil repellency with little change in strength and whiteness