Analyzing differences in the costs of treatment across centers within economic evaluations

Objectives: Assessments of health technologies increasingly include economic evaluations conducted alongside clinical trials. One particular concern with economic evaluations conducted alongside clinical trials is the generalizability of results from one setting to another. Much of the focus relating to this topic has been on the generalizability of results between countries, However, the characteristics of clinical trial design require further consideration of the generalizability of cost data between centers within a single country, which could be important in decisions about adoption of the new technology. Methods: We used data from a multicenter clinical trial conducted in the United Kingdom to assess the degree of variation in costs between patients and between treatment centers and the determinants of the degree of such variation. Results: The variation between patients was statistically significant for both the experimental and conventional treatments. However, the degree of variation between centers was only statistically significant for the experimental treatment. Such variation appeared to be a result of hospital practice, such as pay ment mechanisms for staff and provision of hostel accommodation, rather than variations in physical resource use or substantive differences in cost structure. Conclusions: Multicenter economic evaluations are necessary for determining the variations in hospital practice and characteristics that can in turn determine the generalizability of study results to other settings. Such analyses can identify issues that may be important in adopting a new health technology. Analysis is required of similar large multicenter trials to confirm these conclusions

Gaussian operator bases for correlated fermions

We formulate a general multi-mode Gaussian operator basis for fermions, to enable a positive phase-space representation of correlated Fermi states. The Gaussian basis extends existing bosonic phase-space methods to Fermi systems and thus enables first-principles dynamical or equilibrium calculations in quantum many-body Fermi systems. We prove the completeness and positivity of the basis, and derive differential forms for products with one- and two-body operators. Because the basis satisfies fermionic superselection rules, the resulting phase space involves only c-numbers, without requiring anti-commuting Grassmann variables

Quantum noise in optical fibers II: Raman jitter in soliton communications

The dynamics of a soliton propagating in a single-mode optical fiber with gain, loss, and Raman coupling to thermal phonons is analyzed. Using both soliton perturbation theory and exact numerical techniques, we predict that intrinsic thermal quantum noise from the phonon reservoirs is a larger source of jitter and other perturbations than the gain-related Gordon-Haus noise, for short pulses, assuming typical fiber parameters. The size of the Raman timing jitter is evaluated for both bright and dark (topological) solitons, and is larger for bright solitons. Because Raman thermal quantum noise is a nonlinear, multiplicative noise source, these effects are stronger for the more intense pulses needed to propagate as solitons in the short-pulse regime. Thus Raman noise may place additional limitations on fiber-optical communications and networking using ultrafast (subpicosecond) pulses.Comment: 3 figure

Quantum noise in optical fibers I: stochastic equations

We analyze the quantum dynamics of radiation propagating in a single mode optical fiber with dispersion, nonlinearity, and Raman coupling to thermal phonons. We start from a fundamental Hamiltonian that includes the principal known nonlinear effects and quantum noise sources, including linear gain and loss. Both Markovian and frequency-dependent, non-Markovian reservoirs are treated. This allows quantum Langevin equations to be calculated, which have a classical form except for additional quantum noise terms. In practical calculations, it is more useful to transform to Wigner or +$P$ quasi-probability operator representations. These result in stochastic equations that can be analyzed using perturbation theory or exact numerical techniques. The results have applications to fiber optics communications, networking, and sensor technology.Comment: 1 figur

Gaussian quantum Monte Carlo methods for fermions

We introduce a new class of quantum Monte Carlo methods, based on a Gaussian quantum operator representation of fermionic states. The methods enable first-principles dynamical or equilibrium calculations in many-body Fermi systems, and, combined with the existing Gaussian representation for bosons, provide a unified method of simulating Bose-Fermi systems. As an application, we calculate finite-temperature properties of the two dimensional Hubbard model.Comment: 4 pages, 3 figures, Revised version has expanded discussion, simplified mathematical presentation, and application to 2D Hubbard mode

Many-body quantum dynamics of polarisation squeezing in optical fibre

We report new experiments that test quantum dynamical predictions of polarization squeezing for ultrashort photonic pulses in a birefringent fibre, including all relevant dissipative effects. This exponentially complex many-body problem is solved by means of a stochastic phase-space method. The squeezing is calculated and compared to experimental data, resulting in excellent quantitative agreement. From the simulations, we identify the physical limits to quantum noise reduction in optical fibres. The research represents a significant experimental test of first-principles time-domain quantum dynamics in a one-dimensional interacting Bose gas coupled to dissipative reservoirs.Comment: 4 pages, 4 figure

String breaking and lines of constant physics in the SU(2) Higgs model

We present results for the ground state and first excited state static potentials in the confinement "phase" of the SU(2) Higgs model. String breaking and the crossing of the energy levels are clearly visible. We address the question of the cut-off effects in our results and observe a remarkable scaling of the static potentials.Comment: LATTICE99(Higgs), 3 pages, 4 figure

Monte Carlo techniques for real-time quantum dynamics

The stochastic-gauge representation is a method of mapping the equation of motion for the quantum mechanical density operator onto a set of equivalent stochastic differential equations. One of the stochastic variables is termed the "weight", and its magnitude is related to the importance of the stochastic trajectory. We investigate the use of Monte Carlo algorithms to improve the sampling of the weighted trajectories and thus reduce sampling error in a simulation of quantum dynamics. The method can be applied to calculations in real time, as well as imaginary time for which Monte Carlo algorithms are more-commonly used. The method is applicable when the weight is guaranteed to be real, and we demonstrate how to ensure this is the case. Examples are given for the anharmonic oscillator, where large improvements over stochastic sampling are observed.Comment: 28 pages, submitted to J. Comp. Phy

The one-loop six-dimensional hexagon integral and its relation to MHV amplitudes in N=4 SYM

We provide an analytic formula for the (rescaled) one-loop scalar hexagon integral $\tilde\Phi_6$ with all external legs massless, in terms of classical polylogarithms. We show that this integral is closely connected to two integrals appearing in one- and two-loop amplitudes in planar $\\mathcal{N}=4$ super-Yang-Mills theory, $\Omega^{(1)}$ and $\Omega^{(2)}$. The derivative of $\Omega^{(2)}$ with respect to one of the conformal invariants yields $\tilde\Phi_6$, while another first-order differential operator applied to $\tilde\Phi_6$ yields $\Omega^{(1)}$. We also introduce some kinematic variables that rationalize the arguments of the polylogarithms, making it easy to verify the latter differential equation. We also give a further example of a six-dimensional integral relevant for amplitudes in $\\mathcal{N}=4$ super-Yang-Mills.Comment: 18 pages, 2 figure