Local Asymptotic Equivalence of the Bai and Ng (2004) and Moon and Perron (2004) Frameworks for Panel Unit Root Testing

This paper considers unit-root tests in large n and large T heterogeneous panels with cross-sectional dependence generated by unobserved factors. We reconsider the two prevalent approaches in the literature, that of Moon and Perron (2004) and the PANIC setup proposed in Bai and Ng (2004). While these have been considered as completely different setups, we show that, in case of Gaussian innovations, the frameworks are asymptotically equivalent in the sense that both experiments are locally asymptotically normal (LAN) with the same central sequence. Using Le Cam's theory of statistical experiments we determine the local asymptotic power envelope and derive an optimal test jointly in both setups. We show that the popular Moon and Perron (2004) and Bai and Ng (2010) tests only attain the power envelope in case there is no heterogeneity in the long-run variance of the idiosyncratic components. The new test is asymptotically uniformly most powerful irrespective of possible heterogeneity. Moreover, it turns out that for any test, satisfying a mild regularity condition, the size and local asymptotic power are the same under both data generating processes. Thus, applied researchers do not need to decide on one of the two frameworks to conduct unit root tests. Monte-Carlo simulations corroborate our asymptotic results and document significant gains in finite-sample power if the variances of the idiosyncratic shocks differ substantially among the cross sectional units

The Astrophysical Multipurpose Software Environment

We present the open source Astrophysical Multi-purpose Software Environment (AMUSE, www.amusecode.org), a component library for performing astrophysical simulations involving different physical domains and scales. It couples existing codes within a Python framework based on a communication layer using MPI. The interfaces are standardized for each domain and their implementation based on MPI guarantees that the whole framework is well-suited for distributed computation. It includes facilities for unit handling and data storage. Currently it includes codes for gravitational dynamics, stellar evolution, hydrodynamics and radiative transfer. Within each domain the interfaces to the codes are as similar as possible. We describe the design and implementation of AMUSE, as well as the main components and community codes currently supported and we discuss the code interactions facilitated by the framework. Additionally, we demonstrate how AMUSE can be used to resolve complex astrophysical problems by presenting example applications.Comment: 23 pages, 25 figures, accepted for A&

Optimal Parameters of Deep Brain Stimulation in Essential Tremor:A Meta-Analysis and Novel Programming Strategy

The programming of deep brain stimulation (DBS) parameters for tremor is laborious and empirical. Despite extensive efforts, the end-result is often suboptimal. One reason for this is the poorly understood relationship between the stimulation parameters' voltage, pulse width, and frequency. In this study, we aim to improve DBS programming for essential tremor (ET) by exploring a new strategy. At first, the role of the individual DBS parameters in tremor control was characterized using a meta-analysis documenting all the available parameters and tremor outcomes. In our novel programming strategy, we applied 10 random combinations of stimulation parameters in eight ET-DBS patients with suboptimal tremor control. Tremor severity was assessed using accelerometers and immediate and sustained patient-reported outcomes (PRO's), including the occurrence of side-effects. The meta-analysis showed no substantial relationship between individual DBS parameters and tremor suppression. Nevertheless, with our novel programming strategy, a significantly improved (accelerometer p = 0.02, PRO p = 0.02) and sustained (p = 0.01) tremor suppression compared to baseline was achieved. Less side-effects were encountered compared to baseline. Our pilot data show that with this novel approach, tremor control can be improved in ET patients with suboptimal tremor control on DBS. In addition, this approach proved to have a beneficial effect on stimulation-related complications

Apache Mahout: Machine Learning on Distributed Dataflow Systems

Apache Mahout is a library for scalable machine learning (ML) on distributed dataflow systems, offering various implementations of classification, clustering, dimensionality reduction and recommendation algorithms. Mahout was a pioneer in large-scale machine learning in 2008, when it started and targeted MapReduce, which was the predominant abstraction for scalable computing in industry at that time. Mahout has been widely used by leading web companies and is part of several commercial cloud offerings. In recent years, Mahout migrated to a general framework enabling a mix of dataflow programming and linear algebraic computations on backends such as Apache Spark and Apache Flink. This design allows users to execute data preprocessing and model training in a single, unified dataflow system, instead of requiring a complex integration of several specialized systems. Mahout is maintained as a community-driven open source project at the Apache Software Foundation, and is available under https://mahout.apache.org

Are we on the right track in DBS surgery for dystonic head tremor?:Polymyography is a promising answer

The clinical benefit of Deep Brain Stimulation (DBS) is associated with electrode positioning accuracy. Intraoperative assessment of clinical effect is therefore key. Evaluating this clinical effect in patients with dystonic head tremor, as opposed to limb tremor, is challenging because the head is fixed in a stereotactic frame. To clinically assess head tremor during surgery, surface electromyography (EMG) electrodes were bilaterally applied to the sternocleidomastoid and cervical paraspinal muscles. This case shows that intraoperative polymyography is an easy and useful tool to assess the clinical effect of DBS electrode positioning