130 research outputs found
Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of combined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical manifestations of specific forms of pathology. Combined drugs that help normalize the central regulatory mechanisms of the development of somatic pathology, improve brain metabolism and hemodynamics, stabilize the cortical-subcortical relationships, the disorders of which lie at the base of many forms of neurological and psychosomatic pathology have been particularly popular in recent years. In this article we propose options for optimizing nootropic therapy with olatropyl, which is a combination of two "true" nootropics - gamma-aminobutyric acid (aminalone) and piracetam in one drug form. Such a combination allows one-stage implementation of a complex of multifaceted and diverse effects on the central nervous system characteristic of both piracetam and aminalone, but achieved through fundamentally different mechanisms of action of these agents. The mechanism of action of olatropil demonstrates the pronounced synergism of the monocomponents of the preparation. This combination allows to reduce the therapeutic dosages of each of the active substances by 2 times, which, in turn, leads to a decrease in the incidence and severity of possible side effects; leveling the exciting effect of piracetam and providing higher safety and efficacy. The drug is an effective tool for the therapy of various forms of cerebrovascular pathology, improving cognitive functions, mental activity, psychoemotional status, autonomic functions, favorably affecting the quality of life of patients. The uniqueness of the mechanism of action of olatropil, consisting in the occurrence of the fact of pharmacodynamic synergy in the combined use of piracetam and aminalone in a single dosage form, contributes to the enhancement of positive pharmacological effects and the leveling of a number of negative elements of pharmacodynamics of preparation constituents
Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.
Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of combined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical manifestations of specific forms of pathology. Combined drugs that help normalize the central regulatory mechanisms of the development of somatic pathology, improve brain metabolism and hemodynamics, stabilize the cortical-subcortical relationships, the disorders of which lie at the base of many forms of neurological and psychosomatic pathology have been particularly popular in recent years. In this article we propose options for optimizing nootropic therapy with olatropyl, which is a combination of two "true" nootropics - gamma-aminobutyric acid (aminalone) and piracetam in one drug form. Such a combination allows one-stage implementation of a complex of multifaceted and diverse effects on the central nervous system characteristic of both piracetam and aminalone, but achieved through fundamentally different mechanisms of action of these agents. The mechanism of action of olatropil demonstrates the pronounced synergism of the monocomponents of the preparation. This combination allows to reduce the therapeutic dosages of each of the active substances by 2 times, which, in turn, leads to a decrease in the incidence and severity of possible side effects; leveling the exciting effect of piracetam and providing higher safety and efficacy. The drug is an effective tool for the therapy of various forms of cerebrovascular pathology, improving cognitive functions, mental activity, psychoemotional status, autonomic functions, favorably affecting the quality of life of patients. The uniqueness of the mechanism of action of olatropil, consisting in the occurrence of the fact of pharmacodynamic synergy in the combined use of piracetam and aminalone in a single dosage form, contributes to the enhancement of positive pharmacological effects and the leveling of a number of negative elements of pharmacodynamics of preparation constituents
Gastrointestinal stromal tumors in elderly patients
To study the age-related characteristics of GISTs development in patients of older age group
Germanium electrodeposition into porous silicon for silicon-germanium alloying
A method of germanium electrodeposition from a GeO2-based aqueous solution into the pore channels of anodic mesoporous silicon formed on n-type highly-doped (100) silicon wafers is described. The effect of deposition time, pore channel shape and preconditioning of porous silicon layers in hydrofluoric acid is evaluated. Recommendations are given in regards to the optimal parameter combinations to ensure uniform pore channel filling with germanium. The possibility of producing silicon-germanium alloys by subsequent rapid heat treatment of the germanium-filled porous silicon layers is established
Fragmentation channels of relativistic Be nuclei in peripheral interactions
Nuclei of Li were accelerated at the JINR Nuclotron. After the
charge-exchange reaction involving these nuclei at an external target a second
Be beam of energy 1.23A GeV was formed. This beam was used to expose
photo-emulsion chambers. The mean free path for inelastic Be interactions
in emulsion =14.00.8 cm coincides within the errors with those
for Li and Li nuclei. More than 10% of the Be events are associated
with the peripheral interactions in which the total charge of the relativistic
fragments is equal to the charge of the Be and in which charged mesons are
not produced. An unusual ratio of the isotopes is revealed in the composition
of the doubly charged Be fragments: the number of He fragments is twice
as large as that of He fragments. In 50% of peripheral interactions, a
Be nucleus decays to two doubly charged fragments. The present paper gives
the channels of the Be fragmentation to charged fragments. In 50% of
events, the Be fragmentation proceeds only to charged fragments involving
no emission of neutrons. Of them, the He+He channel dominates, the
He+d+p and Li+pchannels constitute 10% each. Two events involving no
emission of neutrons are registered in the 3-body He+t+p and He+d+d
channels. The mean free path for the coherent dissociation of relativistic
Be nuclei to He+He is 71 m. The particular features of the
relativistic Be fragmentation in such peripheral interactions are explained
by the He+He 2-cluster structure of the Be nucleus.Comment: 10 pages, 3 figures, 3 tables, conference: Conference on Physics of
Fundamental Interactions, Moscow, Russia, 5-9 Dec 200
Selective electrochemical deposition of indium in-between silicon nanowire arrays fabricated by metal-assisted chemical etching
Indium electrodeposition in-between silicon nanowire arrays fabricated by silver-assisted chemical etching of lightly-doped (100)-oriented silicon wafers is evaluated. It is concluded based on SEM and EDX analysis of indium's distribution that, by utilizing pulsed-mode electrodeposition and maintaining a sufficiently low duty cycle value, indium particles can be formed exclusively at the very bottom of each consecutive pore on the residual silver particles left over from metal-assisted etching. This result differs significantly from irregular pore filling along with surface and subsurface deposition observed in the cases of continuous galvanostatic deposition regimes at prolonged durations or in the absence of residual silver particles. Bottommost fusible metal deposit localization, which is unattainable on porous silicon fabricated by electrochemical anodization, is presumed to be optimal for the growth of germanium crystallites inside the pores via the electrochemical liquid-liquid-solid approach and subsequent silicon-germanium alloy formation through thermal annealing
Role of the Nuclear and Electromagnetic Interactions in the Coherent Dissociation of the Relativistic Li Nucleus into the H + He Channel
The differential cross section in the transverse momentum and a total
cross section of mb for the coherent dissociation of a 3-A-GeV/
Li nucleus through the HHe channel have been measured on emulsion
nuclei. The observed dependence of the cross section is explained by the
predominant supposition of the nuclear diffraction patterns on light (C, N, O)
and heavy (Br, Ag) emulsion nuclei. The contributions to the cross section from
nuclear diffraction ( MeV/) and Coulomb MeV/)
dissociations are calculated to be 40.7 and 4 mb, respectively.Comment: ISSN 0021-3640, Pleiades Publishing, Ltd., 200
Rare meteorites common in the Ordovician period
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Most meteorites that fall today are H and L type ordinary chondrites, yet the main belt asteroids best positioned to deliver meteorites are LL chondrites 1,2. This suggests that the current meteorite flux is dominated by fragments from recent asteroid breakup events 3,4 and therefore is not representative over longer (100-Myr) timescales. Here we present the first reconstruction of the composition of the background meteorite flux to Earth on such timescales. From limestone that formed about one million years before the breakup of the L-chondrite parent body 466 Myr ago, we have recovered relict minerals from coarse micrometeorites. By elemental and oxygen-isotopic analyses, we show that before 466 Myr ago, achondrites from different asteroidal sources had similar or higher abundances than ordinary chondrites. The primitive achondrites, such as lodranites and acapulcoites, together with related ungrouped achondrites, made up ∼15-34% of the flux compared with only ∼0.45% today. Another group of abundant achondrites may be linked to a 500-km cratering event on (4) Vesta that filled the inner main belt with basaltic fragments a billion years ago 5. Our data show that the meteorite flux has varied over geological time as asteroid disruptions create new fragment populations that then slowly fade away from collisional and dynamical evolution. The current flux favours disruption events that are larger, younger and/or highly efficient at delivering material to Earth
- …