Characterization of an inertial micro gripper based on adhesion forces

Adhesive forces become predominant in the micro world comparing to the gravity effect implying the development of new micro manipulation strategies. This paper presents the design and conception of a gripper that use the inertial principle for the release (applying a high acceleration, in the order of 10’000g) and the adhesion for catching a micro part of 50μm with the goal of precisely control the position after release. Experiments were conducted and showed a positioning repeatability of 2μm to 6μm depending on the relative humidity with a success rate of more than 90%

Cyclosporine A reduces microvascular obstruction and preserves left ventricular function deterioration following myocardial ischemia and reperfusion

Postconditioning and cyclosporine A prevent mitochondrial permeability transition pore opening providing cardioprotection during ischemia/reperfusion. Whether microvascular obstruction is affected by these interventions is largely unknown. Pigs subjected to coronary occlusion for 1 h followed by 3 h of reperfusion were assigned to control (n = 8), postconditioning (n = 9) or cyclosporine A intravenous infusion 10-15 min before the end of ischemia (n = 8). Postconditioning was induced by 8 cycles of repeated 30-s balloon inflation and deflation. After 3 h of reperfusion magnetic resonance imaging, triphenyltetrazolium chloride/Evans blue staining and histopathology were performed. Microvascular obstruction (MVO, percentage of gadolinium-hyperenhanced area) was measured early (3 min) and late (12 min) after contrast injection. Infarct size with double staining was smaller in cyclosporine (46.2 ± 3.1 %, P = 0.016) and postconditioning pigs (47.6 ± 3.9 %, P = 0.008) versus controls (53.8 ± 4.1 %). Late MVO was significantly reduced by cyclosporine (13.9 ± 9.6 %, P = 0.047) but not postconditioning (23.6 ± 11.7 %, P = 0.66) when compared with controls (32.0 ± 16.9 %). Myocardial blood flow in the late MVO was improved with cyclosporine versus controls (0.30 ± 0.06 vs 0.21 ± 0.03 ml/g/min, P = 0.002) and was inversely correlated with late-MVO extent ($R^{2}$ = 0.93, P\0.0001). Deterioration of left ventricular ejection fraction (LVEF) between baseline and 3 h of reperfusion was smaller with cyclosporine (-7.9 ± 2.4 %, P = 0.008) but not postconditioning (-12.0 ± 5.5 %, P = 0.22) when compared with controls (-16.4 ± 5.5 %). In the three groups, infarct size (\beta = -0.69, P\0.001) and late MVO (\beta = -0.33, P = 0.02) were independent predictors of LVEF deterioration following ischemia/reperfusion (R^{2} = 0.73, P\0.001). Despite both cyclosporine A and postconditioning reduce infarct size, only cyclosporine A infusion had a beneficial effect on microvascular damage and was associated with better preserved LV function when compared with controls

Testing J/psi Production and Decay Properties in Hadronic Collisions

The polar and azimuthal angular distributions for the lepton pair arising from the decay of a J/psi meson produced at transverse momentum p_T balanced by a photon [or gluon] in hadronic collisions are calculated in the color singlet model (CSM). It is shown that the general structure of the decay lepton distribution is controlled by four invariant structure functions, which are functions of the transverse momentum and the rapidity of the J/psi. We found that two of these structure functions [the longitudinal and transverse interference structure functions] are identical in the CSM. Analytical and numerical results are given in the Collins-Soper and in the Gottfried-Jackson frame. We present a Monte Carlo study of the effect of acceptance cuts applied to the leptons and the photon for J/psi+ gamma production at the Tevatron.Comment: 22 pages (LaTeX) plus 11 postscript figures, MAD/PH/822, YUMS94-11. Figures are available from the authors or as a compressed tar file via anonymous ftp at phenom.physics.wisc.edu in directory {}~pub/preprints/madph-94-822-figs.tar.

Probing scalar-pseudoscalar mixing in the CP violating MSSM at high-energy e+e−e^+e^- colliders

We study the production processes $e^+e^-\to H^0_iZ$, $H^0_iH^0_j$ and $H^0_i\nu_e\overline \nu_e$ in the context of the CP violating MSSM. In a given channel we show that the cross-section for all i (=1,2,3) can be above 0.1 fb provided M_{H_{2,3}}\la 300 GeV. This should be detectable at a Next Linear Collider and would provide evidence for scalar-pseudoscalar mixing.Comment: 17 pages, RevTex, 4 ps figures, figure 4 changed, minor modifications to text, version to appear in PR

Resumming the color-octet contribution to e+ e- -> J/psi + X

Recent observations of the spectrum of J/psi produced in e+ e- collisions at the Upsilon(4S) resonance are in conflict with fixed-order calculations using the Non-Relativistic QCD (NRQCD) effective field theory. One problem is that leading order color-octet mechanisms predict an enhancement of the cross section for J/psi with maximal energy that is not observed in the data. However, in this region of phase space large perturbative corrections (Sudakov logarithms) as well as enhanced nonperturbative effects are important. In this paper we use the newly developed Soft-Collinear Effective Theory (SCET) to systematically include these effects. We find that these corrections significantly broaden the color-octet contribution to the J/psi spectrum. Our calculation employs a one-stage renormalization group evolution rather than the two-stage evolution used in previous SCET calculations. We give a simple argument for why the two methods yield identical results to lowest order in the SCET power counting.Comment: 27 pages, 7 figure

Color-Singlet ψQ\psi_Q Production at e+e−e^+e^- Colliders

We calculate in closed form the complete ${\mathcal O}(\alpha_s^2)$ color-singlet differential cross section for $e^+e^- \to \gamma^* \to \psi_Q+X$ scattering. The cross section reduces at high energies to a heavy quark fragmentation form. We find that the energy scale at which the approximate fragmentation result becomes reliable exceeds the $\psi_Q$ mass by more than an order of magnitude. We also discuss the color-singlet model's predictions for direct $J/\psi$ angular and energy distributions at CLEO.Comment: 17 pages RevTeX, 5 embedded ps/eps figure

Subanesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networks

Acute treatment with subanesthetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely utilized as a translational model for schizophrenia. However, how acute NMDA receptor blockade impacts on brain functioning at a systems level, to elicit translationally relevant symptomatology and behavioral deficits, has not yet been determined. Here, for the first time, we apply established and recently validated topological measures from network science to brain imaging data gained from ketamine-treated mice to elucidate how acute NMDA receptor blockade impacts on the properties of functional brain networks. We show that the effects of acute ketamine treatment on the global properties of these networks are divergent from those widely reported in schizophrenia. Where acute NMDA receptor blockade promotes hyperconnectivity in functional brain networks, pronounced dysconnectivity is found in schizophrenia. We also show that acute ketamine treatment increases the connectivity and importance of prefrontal and thalamic brain regions in brain networks, a finding also divergent to alterations seen in schizophrenia. In addition, we characterize how ketamine impacts on bipartite functional interactions between neural subsystems. A key feature includes the enhancement of prefrontal cortex (PFC)-neuromodulatory subsystem connectivity in ketamine-treated animals, a finding consistent with the known effects of ketamine on PFC neurotransmitter levels. Overall, our data suggest that, at a systems level, acute ketamine-induced alterations in brain network connectivity do not parallel those seen in chronic schizophrenia. Hence, the mechanisms through which acute ketamine treatment induces translationally relevant symptomatology may differ from those in chronic schizophrenia. Future effort should therefore be dedicated to resolve the conflicting observations between this putative translational model and schizophrenia

Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis

Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. © 2022 The Author(s