473 research outputs found
New Treatment Options in Advanced Stage Follicular Lymphoma
Follicular lymphoma is one of the most common non-Hodgkin's lymphomas with an expected survival of more than 20 years for the majority of patients. This impressive outcome has been achieved with the introduction of immunochemotherapy, as first line treatment with remissions lasting over 8 years, followed by other treatment options at first or subsequent relapse. However, certain groups of patients still have a poor prognosis. In recent years the efficacy of chemotherapy regimens has been augmented by new compounds selectively targeting the cell surface, intracellular pathways, and/or the microenvironment. Some of these are beginning to change the therapeutic landscape. This review summarizes prognostic factors in follicular lymphoma in order to identify patients with greatest medical need for these new treatment options and reviews recent data from prospective clinical studies testing new agents in first-line and relapsed follicular lymphoma. Finally, we assess the current role of immunochemotherapy and discuss the requirements for future clinical trials
EHA/ESMO Clinical Practice Guidelines for the Management of Malignant Lymphoma: Recommendations for the Second Phase of the COVID-19 Pandemic
No abstract availabl
Performance of the EUDET-type beam telescopes
Test beam measurements at the test beam facilities of DESY have been
conducted to characterise the performance of the EUDET-type beam telescopes
originally developed within the EUDET project. The beam telescopes are equipped
with six sensor planes using MIMOSA26 monolithic active pixel devices. A
programmable Trigger Logic Unit provides trigger logic and time stamp
information on particle passage. Both data acquisition framework and offline
reconstruction software packages are available. User devices are easily
integrable into the data acquisition framework via predefined interfaces.
The biased residual distribution is studied as a function of the beam energy,
plane spacing and sensor threshold. Its standard deviation at the two centre
pixel planes using all six planes for tracking in a 6\,GeV
electron/positron-beam is measured to be
(2.88\,\pm\,0.08)\,\upmu\meter.Iterative track fits using the formalism of
General Broken Lines are performed to estimate the intrinsic resolution of the
individual pixel planes. The mean intrinsic resolution over the six sensors
used is found to be (3.24\,\pm\,0.09)\,\upmu\meter.With a 5\,GeV
electron/positron beam, the track resolution halfway between the two inner
pixel planes using an equidistant plane spacing of 20\,mm is estimated to
(1.83\,\pm\,0.03)\,\upmu\meter assuming the measured intrinsic resolution.
Towards lower beam energies the track resolution deteriorates due to increasing
multiple scattering. Threshold studies show an optimal working point of the
MIMOSA26 sensors at a sensor threshold of between five and six times their RMS
noise. Measurements at different plane spacings are used to calibrate the
amount of multiple scattering in the material traversed and allow for
corrections to the predicted angular scattering for electron beams
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