Carsey Perspectives: Local Owners Driving Lasting Solutions, An Innovative Model for International Development and Poverty Alleviation

In this perspectives brief, authors Ilona Drew, Fiona Wilson, Bill Maddocks discuss a case study that was examined as part of the Social Sector Franchise Initiative (SSFI), a project of the Center for Social Innovation and Enterprise at the University of New Hampshire. This case study describes Jibu, a social sector franchise seeking to simultaneously provide lasting access to affordable clean drinking water and to contribute to economic development through a network of locally-owned franchise businesses in East Africa and beyond. First-time social entrepreneurs are equipped with Jibu’s water purification and other equipment, branding, training, and the capital required to launch franchise locations selling drinking water at prices lower than the charcoal it would cost to boil it

Carsey Perspectives: Meeting Farmers Where They Are, Increasing Agricultural Sustainability in Malawi Through Business Format Franchising

In this perspectives brief, authors Ilona Drew, Abraham DeMaio, Bill Maddocks, and Fiona Wilson discuss a case study that was examined as part of the Social Sector Franchise Initiative (SSFI), a project of the Center for Social Innovation and Enterprise at the University of New Hampshire. This case study profiles Ziweto Enterprises, a social venture in Malawi using franchising methodology to scale its growth. Ziweto’s Agrovet Shops are “one-stop” franchised shops run by recent graduates of veterinary medicine and agricultural colleges that offer diverse veterinary and agricultural products and services. Ziweto’s products and services provide key support to the nation’s smallholder farmers, supporting animal husbandry as well as crop output

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

An Innovative Model for International Development and Poverty Alleviation

As outlined in the United Nations' Sustainable Development Goals, there is an urgent need for mechanisms that effectively scale proven interventions for tackling some of humanity's toughest challenges (United Nations 2015). While there are exemplary models that have proven to be highly effective, there are relatively few examples that have achieved large-scale replication

Carsey Perspectives: Meeting Farmers Where They Are

This case study provides an overview of Ziweto Enterprises, a social venture using franchising methodology to scale its growth. The goal of this study is to present a clear picture of how the starting stages of a social franchise can expand and thrive in a developing country such as Malawi. By discussing Ziweto's history, business model, operations, challenges, successes, decision-making process, social impact, and projected future, this case study aims to provide insight into the application of business format franchising to address social problems

Health-status outcomes with invasive or conservative care in coronary disease

BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline