The 2005 HST Calibration Workshop Hubble After the Transition to Two-Gyro Mode

The 2005 HST Calibration Workshop was held at the Space Telescope Science Institute during October 26, 2005 to bring together members of the observing community, the instrument development teams, and the STScI instrument support teams to share information and techniques. Presentations included the two-gyro performance of HST and FGS, advances in the calibration of a number of instruments, the results of other instruments after their return from space, and the status of still others which are scheduled for installation during the next servicing mission. Cross-calibration between HST and JWST was discussed, as well as the new Guide Star Catalog and advances in data analysis software. This book contains the published record of the workshop, while all the talks and posters are available electronically on the workshop Web site

The Tumorigenicity of Mouse Embryonic Stem Cells and In Vitro Differentiated Neuronal Cells Is Controlled by the Recipients' Immune Response

Embryonic stem (ES) cells have the potential to differentiate into all cell types and are considered as a valuable source of cells for transplantation therapies. A critical issue, however, is the risk of teratoma formation after transplantation. The effect of the immune response on the tumorigenicity of transplanted cells is poorly understood. We have systematically compared the tumorigenicity of mouse ES cells and in vitro differentiated neuronal cells in various recipients. Subcutaneous injection of 1×106 ES or differentiated cells into syngeneic or allogeneic immunodeficient mice resulted in teratomas in about 95% of the recipients. Both cell types did not give rise to tumors in immunocompetent allogeneic mice or xenogeneic rats. However, in 61% of cyclosporine A-treated rats teratomas developed after injection of differentiated cells. Undifferentiated ES cells did not give rise to tumors in these rats. ES cells turned out to be highly susceptible to killing by rat natural killer (NK) cells due to the expression of ligands of the activating NK receptor NKG2D on ES cells. These ligands were down-regulated on differentiated cells. The activity of NK cells which is not suppressed by cyclosporine A might contribute to the prevention of teratomas after injection of ES cells but not after inoculation of differentiated cells. These findings clearly point to the importance of the immune response in this process. Interestingly, the differentiated cells must contain a tumorigenic cell population that is not present among ES cells and which might be resistant to NK cell-mediated killing

The autonomy of public colleges.

x, 107 p.; 21 cm

Handbook of academic evaluation

xviii, 518 p.; 23 cm