39 research outputs found
First order parent formulation for generic gauge field theories
We show how a generic gauge field theory described by a BRST differential can
systematically be reformulated as a first order parent system whose spacetime
part is determined by the de Rham differential. In the spirit of Vasiliev's
unfolded approach, this is done by extending the original space of fields so as
to include their derivatives as new independent fields together with associated
form fields. Through the inclusion of the antifield dependent part of the BRST
differential, the parent formulation can be used both for on and off-shell
formulations. For diffeomorphism invariant models, the parent formulation can
be reformulated as an AKSZ-type sigma model. Several examples, such as the
relativistic particle, parametrized theories, Yang-Mills theory, general
relativity and the two dimensional sigma model are worked out in details.Comment: 36 pages, additional sections and minor correction
Parent formulation at the Lagrangian level
The recently proposed first-order parent formalism at the level of equations
of motion is specialized to the case of Lagrangian systems. It is shown that
for diffeomorphism-invariant theories the parent formulation takes the form of
an AKSZ-type sigma model. The proposed formulation can be also seen as a
Lagrangian version of the BV-BRST extension of the Vasiliev unfolded approach.
We also discuss its possible interpretation as a multidimensional
generalization of the Hamiltonian BFV--BRST formalism. The general construction
is illustrated by examples of (parametrized) mechanics, relativistic particle,
Yang--Mills theory, and gravity.Comment: 26 pages, discussion of the truncation extended, typos corrected,
references adde
Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia : results of the EORTC CLG 58881 and 58951 trials
info:eu-repo/semantics/publishe
Reduction of microglial activity in a model of multiple sclerosis by dipyridamole
BACKGROUND: Despite extensive and persistent activation of microglia in multiple sclerosis (MS), microglia inhibitors have not yet been identified for treatment of the disorder. We sought to identify medications already in clinical use that could inhibit the activation of microglia. On the basis of the reported inhibitory effects of dipyridamole on phosphodiesterase activity that result in the production of various anti-inflammatory outcomes, we selected it for study. Dipyridamole is used clinically for secondary prevention in stroke. In this study, dipyridamole was examined using microglia in culture and in the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). RESULTS: We found that dipyridamole attenuated the elevation of several cytokines and chemokines in human microglia caused by Toll-like receptor stimulation. Morphological characteristics of activated microglia in culture were also normalized by dipyridamole. In mice, dipyridamole decreased the clinical severity of EAE and reduced microglial activity and other histological indices of EAE in the spinal cord. CONCLUSIONS: Dipyridamole is an inhibitor of microglia activation and may have a role in MS and other neurological conditions to attenuate microglial activity
Evidence for a Modulatory Role of Ih on the Firing of a Subgroup of Midbrain Dopamine Neurons
A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific blocker ZD7288. In two-thirds of the cells, low concentrations of ZD7288 induced a decrease of the spontaneous firing. The maximal inhibition was about 40% and the mean IC50 was 1.6 microM. This effect was probably direct because it persisted in the presence of antagonists of various receptors. These concentrations of ZD7288 had no effect in the remaining one third of the examined cells. However, the highest concentration of ZD7288 (300 microM) abolished the firing of all dopaminergic neurons, probably by a mechanism unrelated to the blockade of Ih. We conclude that Ih controls to a certain extent the firing of a majority of midbrain dopaminergic neurons
Paravertebral Burkitt's Lymphoma in a Child: An Unusual Presentation
Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitt's lymphoma. This is a rare location of sporadic Burkitt's lymphoma with neurologic syndrome as first symptoms
A 19-miRNA SIGNATURE PREDICTS RELAPSE IN AVERAGE RISK PRE-B ACUTE LYMPHOBLASTIC LEUKEMIA
peer reviewe
Sickle cell disease from Africa to Belgium, from neonatal screening to clinical management.
To describe the severity of sickle cell disease (SCD) in newborns in Belgium and evaluate the impact of neonatal screening (NS) on clinical outcome.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe