EFFECT OF CIRCADIAN OSCILLATION DURING FOOD DEPRIVATION ON HEART RATE IN OBESE MEN

The purpose of the study was to find out the effect of circadian oscillation during food deprivation on heart rate among obese men. To achieve the purpose of the present study, sixty obese men from Islamiah College, Vaniyambadi, Tamilnadu, India were selected as subjects at random and their ages ranged from 18 to 25 years. The subjects were divided into four equal groups of fifteen subjects each. Group I acted as Experimental Group I (Food Deprivation Training), Group II acted as Experimental Group II (Physical training), Group III acted as Experimental Group III (Food Deprivation & Physical training) and Group IV acted as Control Group. The requirement of the experiment procedures, testing as well as training schedule was explained to the subjects so as to get full co-operation of the effort required on their part and prior to the administration of the study. Heart rate was assessed by using stethoscope. Experimental Group I was exposed to food deprivation training, Experimental Group II was exposed to physical training, Experimental Group III was exposed to food deprivation & physical training and Control Group was not exposed to any experimental training other than their regular daily activities. The duration of experimental period was 120 days. After the experimental treatment, all the sixty subjects were tested on heart rate. This final test scores formed as post test scores of the subjects. The pre test and post test scores were subjected to statistical analysis using Analysis of Covariance (ANCOVA) to find out the significance among the mean differences, whenever the ‘F’ ratio for adjusted test was found to be significant, Scheffe’s post hoc test was used. In all cases 0.05 level of significance was fixed to test hypotheses. The findings of the study showed that the combined food deprivation and physical training group showed changes in heart rate than the other experimental and control groups

Targeting the hypoxic fraction of tumours using hypoxia activated prodrugs

The presence of a microenvironment within most tumours containing regions of low oxygen tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is known to promote the development of an aggressive phenotype, resistance to both chemotherapy and radiotherapy and is strongly associated with poor clinical outcome. Paradoxically, it is recognised as a high priority target and one therapeutic strategies designed to eradicate hypoxic cells in tumours are a group of compounds known collectively as hypoxia activated prodrugs (HAPs) or bioreductive drugs. These drugs are inactive prodrugs that require enzymatic activation (typically by 1 or 2 electron oxidoreductases) to generate cytotoxic species with selectivity for hypoxic cells being determined by (i) the ability of oxygen to either reverse or inhibit the activation process and (ii) the presence of elevated expression of oxidoreductases in tumours. The concepts underpinning HAP development were established over 40 years ago and have been refined over the years to produce a new generation of HAPs that are under preclinical and clinical development. The purpose of this article is to describe current progress in the development of HAPs focusing on the mechanisms of action, preclinical properties and clinical progress of leading examples

ON PRIME LABELING OF THETA GRAPH

A graph with vertex set is said to have a prime labeling if its vertices are labeled with distinct integers such that for each edge the labels assigned to and are relatively prime. A graph which admits prime labeling is called a prime graph. In this paper; we investigate prime labeling of Theta graph. We also discuss prime labeling in the context of some graph operations namely Fusion, Duplication, Switching and Path unio

A STUDY ON CHEMICAL REACTION AND SORET EFFECT ON A STEADY MHD FLOW OVER A VERTICAL POROUS PLATE WITH OHMIC HEATING, VISCOUS DISSIPATION AND RADIATION

The present article deals with the analysis of steady MHD flow of an incompressible and electrically conducting viscous fluid through a vertical porous plate with ohmic heating, viscous dissipation and radiation in presence of chemical reaction and Soret effect. The governing non-linear partial differential equations are transformed into a set of coupled ordinary differential equations which are then solved analytically by using the regular perturbation techniques. The effect of various parameters like Schmidt number (Sc), Prandtl number (Pr), Grashof number , Modified Grashof number , Magnetic parameter (M), Radiation parameter (F), Porosity parameter (K), Chemical reaction parameter (R) and Soret number (Sr) on velocity, temperature and concentration profiles and also on skin friction, Nusselt number and Sherwood number are discussed with the help of numerical values and the relevant graphs

EFFECT OF CIRCADIAN OSCILLATION DURING FOOD DEPRIVATION ON BLOOD SUGAR IN OBESE MEN

The purpose of the study was to find out the effect of circadian oscillation during food deprivation on blood sugar among obese men. To achieve the purpose of the present study, sixty obese men from Islamiah College, Vaniyambadi, Tamilnadu, India were selected as subjects at random and their ages ranged from 18 to 25 years. The subjects were divided into four equal groups of fifteen subjects each. Group I acted as Experimental Group I (Food Deprivation Training), Group II acted as Experimental Group II (Physical training), Group III acted as Experimental Group III (Food Deprivation & Physical training) and Group IV acted as Control Group. The requirement of the experiment procedures, testing as well as training schedule was explained to the subjects so as to get full co-operation of the effort required on their part and prior to the administration of the study. Blood sugar was assessed by lab test. Experimental Group I was exposed to food deprivation training, Experimental Group II was exposed to physical training, Experimental Group III was exposed to food deprivation & physical training and Control Group was not exposed to any experimental training other than their regular daily activities. The duration of experimental period was 120 days. After the experimental treatment, all the sixty subjects were tested on blood sugar. This final test scores formed as post test scores of the subjects. The pre test and post test scores were subjected to statistical analysis using ‘t’ test. In all cases 0.05 level of significance was fixed to test hypotheses. The findings of the study showed that the all the experimental groups showed changes in blood sugar than the control group

EFFECT OF CIRCADIAN OSCILLATION DURING FOOD DEPRIVATION ON STRENGTH ENDURANCE IN OBESE MEN

The purpose of the study was to find out the effect of circadian oscillation during food deprivation on strength endurance among obese men. To achieve the purpose of the present study, sixty obese men from Islamiah College, Vaniyambadi, Tamilnadu, India were selected as subjects at random and their ages ranged from 18 to 25 years. The subjects were divided into four equal groups of fifteen subjects each. Group I acted as Experimental Group I (Food Deprivation Training), Group II acted as Experimental Group II (Physical training), Group III acted as Experimental Group III (Food Deprivation & Physical training) and Group IV acted as Control Group. The requirement of the experiment procedures, testing as well as training schedule was explained to the subjects so as to get full co-operation of the effort required on their part and prior to the administration of the study. Strength endurance was assessed by 30 sec endurance jump test. Experimental Group I was exposed to food deprivation training, Experimental Group II was exposed to physical training, Experimental Group III was exposed to food deprivation & physical training and Control Group was not exposed to any experimental training other than their regular daily activities. The duration of experimental period was 120 days. After the experimental treatment, all the sixty subjects were tested on strength endurance. This final test scores formed as post test scores of the subjects. The pre test and post test scores were subjected to statistical analysis using Analysis of Covariance (ANCOVA) to find out the significance among the mean differences, whenever the ‘F’ ratio for adjusted test was found to be significant, Scheffe’s post hoc test was used. In all cases 0.05 level of significance was fixed to test hypotheses. The findings of the study showed that the combined food deprivation and physical training group showed changes in strength endurance than the other experimental and control groups

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