A Giant Lipoma In The Hand - Report Of A Rare Case

A 38 years old male patient presented with a large painless swelling in the right palm with ultrasound examination suggestive of fatty nature of the swelling MRI showing a well-circumscribed soft tissue swelling in the deep palmar space. The giant tumor of 6.5 X 4 cm was excised and the patient was symptom free two years following the surgery

The effect of Asthapada Panchaloha Shalaka Agnikarma in the pain management of Gridhrasi w.s.r. to Sciatica

Gridhrasi is a disease explained by Brihatrayees in the context of Vatavyadhi Adhyaya. The earliest reference about the details of Gridhrasi is available from Sushruta Samhita (1500 BC). Gridhrasi is included in Vatajna Natmaja Vyadhi and also considered as Mahagada by Acharya Charaka. In all Ayurvedic literature, there is no direct reference regarding Nidana, but it is included in Vataja Nanatmaja Vyadhi, general Vata Prakopaka Hetus are to be considered. On the basis of symptoms, Gridhrasi can be correlated with the disease Sciatica in the modern parlance, which occurs because of spinal nerve irritation and characterized by its distinct nature of pain in distribution of sciatic nerve and often it is associated with lumbago. The Gridhrasi is commonly seen in society as a major problem which incapacitates patient to perform his daily routine activities because of severe pain from Kati Pradesha to Padanguli. In modern medicine in reference to sciatica treatment, there is no definite curative treatment other than symptomatic management. Objectives of the study was to evaluate the effect of Asthapada Panchaloha Shalaka Agnikarma in the pain management of Gridhrasi w.s.r. to Sciatica and to compare the effect of Bindu Panchaloha Shalaka Agnikarma in the pain management of Gridhrasi. In present study 40 patients with confirmed clinical diagnosis of Gridhrasi/Sciatica were selected randomly and divided into two groups of each 20 patients. Group A patients were treated with Asthapada Panchaloha Shalaka Agnikarma and Group B patients were treated with Bindu Panchaloha Shalaka Agnikarma. After the treatment it was observed that there was statistically significant results in the main signs and symptoms i.e. pain in lumbar region, numbness, SLR test. The study shows that the treatment is statistically significant in Group A when compared to Group B. Group A overall result is 87.29% and Group B overall result is 84.64%

MANAGEMENT OF GUILLAIN BARRE SYNDROME THROUGH AYURVEDA-A CASE STUDY

Guillain-Barré syndrome (GBS) is an acute, rapidly evolving are flexic motor paralysis with or without sensory disturbance. It occurs year around at arate of between 1 and 4 cases per 100,000 annually. Age is an important factor determining outcome, and prognosis. In children is said to be favourable as compared to adults. Direct correlation of GBS with Ayurvedic terminology is difficult. The presentation and Doshadooshyasamoorchana is considered first and then one should proceed with the treatment. Here a case of 7 year old female child presented with sudden onset of loss of power in lower limb, unable to get up, walk and stand with a past history of fever brought to OPD of SKAMC&HRC Bangalore. She was provisionally diagnosed as a case of acute inflammatory demyelinating polyneuropathy (AIDP-type of GBS). As per Ayurvedic classics, this condition we have taken as Sarvangavata (Vata affecting the whole body) which precedes Jwara (H/O fever before onset of symptoms). Hence, the line of treatment we have adopted Jwara Chikitsa and Vatavyadhichikitsa which included Aamapachana as well as Brihmanachikitsa along with Shamanoushadhis. The outcome was very remarkable with the patient able to walk on her own

A SIMPLE INDEX OF SMOKING

Background: Cigarette smoking is implicated in a large number of diseases and other adverse health conditions. Among the dimensions of smoking are number of cigarettes smoked per day, duration of smoking, passive smoking, smoking of filter cigarettes, age at start, and duration elapsed since quitting by ex-smokers. The practice so far is to study most of these separately. We develop a simple index that integrates these dimensions of smoking into a single metric, and suggest that this index be developed further. Method: The index is developed under a series of natural assumptions. Broadly, these are (i) the burden of smoking monotonically increases with the cigarette-years but it is more severe in the beginning, (ii) start of smoking early in life is more burdensome than a late start, and (iii) the burden gradually reverses as the duration elapsed since cessation by ex-smokers increases. Result: The index so arrived is: S = (3 – a/15)*1/2*sqrt[sumof(pi*ni*xi) – 0.5] - y for S greater than equal to 0, and sumof(pi*ni*xi) greater than equal to 0.5; otherwise zero (use a =30 for a\u3e30); where i = 1, 2, …, I, and I is the number of segments in life with different smoking pattern and a is the age at start of smoking, pi is the proportion of smoke inhaled in case of passive smoking (or adjustment for filter cigarettes or for other forms of smoking), xi is the number of cigarettes smoked for ni years, and y is the number of years elapsed since cessation by ex-smokers. Negative values of S are to be considered equal to zero. Examples are given that demonstrate the use of this index. Conclusion: Just as almost any other composite index, our index too could be good as a comprehensive measure of burden of smoking but not to study its individual dimensions. This measures the present burden in absolute sense and not the risk of smoking-related diseases. Like body-mass index, the smoking index may have good correlation with the risk of some diseases and poor for many others, depending upon the extent to which the risk of disease agrees to our postulations

A Comparative Study on Social Maturity among School Going Rural Teenagers; Gujarat, INDIA

School is a place where young people experiment with social roles and develop new aspects to their sense of self. Teenage is a period of personal development during which a young person must establish a sense of individual identity and feeling of self-worth. The aims of the study were 1. To find out the level of Social Maturity and gender difference among girls and boys in the age group of 13 to 15 years at Secondary Schools.2.To study the impact of counseling on Social Maturity of teenagers.Two villages of Dantiwada Block, Banaskantha District of Gujarat state were randomly selected for the study. 120 school going teenagers (inclusive of 60 girls and 60 boys) of the respective villages were randomly selected. Self-made questionnaire was prepared for getting the background/ basic profile of the child. One standardized tool “Social Maturity Scale (RSMS)” by developed by Nalini Rao was used for assessment of Social Maturity of the teenagers. Result revealed that More than half approximate 70 percent of the students of rural area were socially matured and there was no significant gender difference among the students on social maturity. This might be because, during the developmental stage adolescents will be self confident, self directed, warm empathic, responsible and competitive, they have the ability to work and have problem solving skills

A Review: Urbanization and Life Satisfaction

With urbanization, the burden to earn more and live rich is mounting and the ability to reach their own /societal expectations lead to pressure that may lead to varied degree of satisfaction in life. Life satisfaction is a subjective assessment of the quality of one’s life. The present study tends to find the criteria that influence life satisfaction of the people in modern world. The following objectives were set to achieve the stated aim (a) To understand life-satisfaction (b) To find determinants of life satisfaction (c) Who are more satisfied with life. The study was conducted through desk research method. Attempts have been made to draw inferences from various researches and reports. The view of multi-angled literatures has been incorporated as felt fit to the context. The results interpreted are that education, increase of income, being married, family size (number of children), good health, connection with community, religious attitude are some important happiness drivers and has positive impact on life satisfaction

Qualities of teachers in Ayurvedic prospect

Teacher is the heart of the education system. In Ayurveda teacher not only create good disciple but also a good Vaidya (physician). In old generation of Guru-Shishya Parampara or in the computerized modern era, Teacher is undisputedly the best among the source of knowledge. One of the primes of any successful education system is the teacher. In medical branches like Ayurveda, one who has the sharp observing capacity can develop the qualities of good teaching. Specially in the field of Ayurveda where the classical text, though the centuries old still stand to be true require the efforts of learned teacher to impart knowledge which is based on his own inferences and experience suitable to the modern era. When one refers the quality of teacher and examiner it looks like some quite identical because who is well aware of the knowledge (teacher) can also become the good examiner of subject, object or knowledge. Ideal author of ancient text Charaka Samhita has truly emphasized on Pariksha i.e. the process of examination. Need of these qualities are to be elaborated more in today's era. These qualities can be developed through the training programs specially conducted in the field of Ayurveda also

Role of Apamarga Yavakshara in the management of Mutrashmari - A Conceptual Study

Mutrashmari is one of the most common disorders of the Mutravaha Srotas. It is one of the Astamahagada and considered as "Yama” because sometimes it causes acute excruciating pain.[1] In contemporary medical science it is correlated with urolithiasis. Symptoms in general include radiating pain from loin to groin, hematuria, burning micturition, malaise. Prevalence of Urolithiasis varies according to geographical distribution, sex and age. The treatment modalities of urolithiasis in conventional science are conservative medications and surgical procedures which are expensive, involve invasive treatments, needs hospitalization and in most of the cases recurrence rate is high. Ayurveda explains variety of Yogas for the management of Mutrashmari. A combination of Apamarga and Yava Kshara is indicated in Mutrashmari as per Rasatarangini.[2] So this study is taken up, to explore the combined effect of Apamarga and Yava Kshara in Mutrashmari keeping in view the shortcomings of different modern medical treatments

E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer

<p>Abstract</p> <p>Background</p> <p>Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as those that are driving the expression of the OEC over-expressed genes, could be the key for OEC genesis and potentially useful tissue and serum markers for malignancy associated with OEC.</p> <p>Methods</p> <p>Using a combination of computational (selection of candidate TF markers and malignancy prediction) and experimental approaches (tissue microarray and western blotting on patient samples) we identified and evaluated E2F5 transcription factor involved in cell proliferation, as a promising candidate regulatory target in early stage disease. Our hypothesis was supported by our tissue array experiments that showed E2F5 expression only in OEC samples but not in normal and benign tissues, and by significantly positively biased expression in serum samples done using western blotting studies.</p> <p>Results</p> <p>Analysis of clinical cases shows that of the E2F5 status is characteristic for a different population group than one covered by CA125, a conventional OEC biomarker. E2F5 used in different combinations with CA125 for distinguishing malignant cyst from benign cyst shows that the presence of CA125 or E2F5 increases sensitivity of OEC detection to 97.9% (an increase from 87.5% if only CA125 is used) and, more importantly, the presence of both CA125 and E2F5 increases specificity of OEC to 72.5% (an increase from 55% if only CA125 is used). This significantly improved accuracy suggests possibility of an improved diagnostics of OEC. Furthermore, detection of malignancy status in 86 cases (38 benign, 48 early and late OEC) shows that the use of E2F5 status in combination with other clinical characteristics allows for an improved detection of malignant cases with sensitivity, specificity, F-measure and accuracy of 97.92%, 97.37%, 97.92% and 97.67%, respectively.</p> <p>Conclusions</p> <p>Overall, our findings, in addition to opening a realistic possibility for improved OEC diagnosis, provide an indirect evidence that a cell-cycle regulatory protein E2F5 might play a significant role in OEC pathogenesis.</p