Dopant Spatial Distributions: Sample Independent Response Function And Maximum Entropy Reconstruction

We demonstrate the use of maximum entropy based deconvolution to reconstruct boron spatial distribution from the secondary ion mass spectrometry (SIMS) depth profiles on a system of variously spaced boron $\delta$-layers grown in silicon. Sample independent response functions are obtained using a new method which reduces the danger of incorporating real sample behaviour in the response. Although the original profiles of different primary ion energies appear quite differently, the reconstructed distributions agree well with each other. The depth resolution in the reconstructed data is increased significantly and segregation of boron at the near surface side of the $\delta$-layers is clearly shown.Comment: 5 two-columne pages, 3 postscript figures, to appear in Phys. Rev. B1

Recommendations for HER2 testing in the UK

Determining the HER2 status of breast carcinomas is a prerequisite for the use of the monoclonal antibody trastuzumab (Herceptin(R)), which has recently been licensed for the treatment of metastatic disease. This necessitates a test based on archival material. The preferred analyses are immunohistochemistry with fluorescent in situ hybridisation (FISH) as a follow up test for ambiguous results. Guidelines have been developed for standardised, well controlled procedures for the provision of reliable results. A group of three reference laboratories has been established to provide advice, quality assurance, and materials, where needed

Toxicity in Beef Cattle Grazing \u3cem\u3eLeucaena leucocephala\u3c/em\u3e in Queensland, Australia

Improved pastures based on the leguminous shrub Leucaena leucocephala (leucaena) are the most productive, profitable and sustainable for beef cattle production in northern Australia. Leucaena forage contains the toxic, non-protein amino acid mimosine, which is rapidly converted to 3-hydroxy-4(1H)-pyridone (DHP) upon ingestion by grazing cattle. This is a potent goitrogen and appetite suppressant. Animals suffering severe DHP toxicity exhibit distinctive symptoms (e.g. hair loss, excessive salivation, goitre and weight loss), while subclinical DHP toxicity can suppress live weight gain by 30-50% without producing any obvious symptoms. Prior to the discovery and introduction of the DHP-degrading rumen bacteria Synergistes jonesii into Australia in 1982, DHP toxicity severely limited animal performance from leucaena pastures and was a major impediment to adoption. Initial rumen inoculation of cattle in Australia with S. jonesii successfully protected them against DHP toxicity and the bacterium appeared to be easily and rapidly transmitted between grazing animals. Consequently many scientists and graziers believed that a single inoculation of a herd with S. jonesii, combined with simple ongoing herd management, was sufficient to overcome the problem of DHP toxicity. However, during the 2003 drought there were several reports of severe leucaena toxicity (including animal deaths) in cattle grazing leucaena in Queensland. Toxicity was evident even in herds that had followed recommended control measures. Preliminary results are presented of a study, designed to ascertain the prevalence and possible causes of leucaena toxicity in Queensland cattle herds. Meat and Livestock Australia Limited funded this research (NBP.340)

Simulations of the Mid-Pliocene Warm Period Using Two Versions of the NASA-GISS ModelE2-R Coupled Model

The mid-Pliocene Warm Period (mPWP) bears many similarities to aspects of future global warming as projected by the Intergovernmental Panel on Climate Change (IPCC, 2007). Both marine and terrestrial data point to high-latitude temperature amplification, including large decreases in sea ice and land ice, as well as expansion of warmer climate biomes into higher latitudes. Here we present our most recent simulations of the mid-Pliocene climate using the CMIP5 version of the NASAGISS Earth System Model (ModelE2-R). We describe the substantial impact associated with a recent correction made in the implementation of the Gent-McWilliams ocean mixing scheme (GM), which has a large effect on the simulation of ocean surface temperatures, particularly in the North Atlantic Ocean. The effect of this correction on the Pliocene climate results would not have been easily determined from examining its impact on the preindustrial runs alone, a useful demonstration of how the consequences of code improvements as seen in modern climate control runs do not necessarily portend the impacts in extreme climates.Both the GM-corrected and GM-uncorrected simulations were contributed to the Pliocene Model Intercomparison Project (PlioMIP) Experiment 2. Many findings presented here corroborate results from other PlioMIP multi-model ensemble papers, but we also emphasize features in the ModelE2-R simulations that are unlike the ensemble means. The corrected version yields results that more closely resemble the ocean core data as well as the PRISM3D reconstructions of the mid-Pliocene, especially the dramatic warming in the North Atlantic and Greenland-Iceland-Norwegian Sea, which in the new simulation appears to be far more realistic than previously found with older versions of the GISS model. Our belief is that continued development of key physical routines in the atmospheric model, along with higher resolution and recent corrections to mixing parameterisations in the ocean model, have led to an Earth System Model that will produce more accurate projections of future climate

The final two redshifts for radio sources from the equatorial BRL sample

Best, Rottgering and Lehnert (1999, 2000a) defined a new sample of powerful radio sources from the Molonglo Reference Catalogue, for which redshifts were compiled or measured for 177 of the 178 objects. For the final object, MRC1059-010 (3C249), the host galaxy is here identified using near-infrared imaging, and the redshift is determined from VLT spectroscopy. For one other object in the sample, MRC0320+053 (4C05.14), the literature redshift has been questioned: new spectroscopic observations of this object are presented, deriving a corrected redshift. With these two results, the spectroscopic completeness of this sample is now 100%. New redshifts are also presented for PKS0742+10 from the Wall & Peacock 2.7 GHz catalogue, and PKS1336+003 from the Parkes Selected Regions. PKS0742+10 shows a strong neutral hydrogen absorption feature in its Lyman-alpha emission profile.Comment: 4 pages. LaTeX. Accepted for publication in MNRA