A Snapshot of How Latino Heterosexual Men Promote Sexual Health Within Their Social Networks: Process Evaluation Findings from an Efficacious Community-Level Intervention

HoMBReS was a community-level social network intervention designed to increase sexual health among Latino heterosexual men who were members of a multi-county soccer league

Predictors of Heavy Episodic Drinking and Weekly Drunkenness Among Immigrant Latinos in North Carolina

Few studies have examined correlates of heavy drinking among rural immigrant Latino men. This analysis identified correlates of typical week drunkenness and past 30-day heavy episodic drinking, within a sample of immigrant Latino men in rural North Carolina (n = 258). In the bivariate analyses, Mexican birth, entering the United States as an adult, and year-round employment were associated with increased odds of typical week drunkenness, and higher acculturation and affiliation with a religion with strict prohibitions against drinking alcohol were associated with lower odds of typical week drunkenness. Being older, Mexican birth, and entering the United States as an adult were associated with increased odds of heavy episodic drinking, and affiliation with a religion with strict prohibitions against drinking alcohol was associated with decreased odds of heavy episodic drinking. In multivariable modeling, only religious affiliation was associated with typical week drunkenness. Mexican birth, entering the United States as an adult and were associated with increased odds of heavy episodic drinking, and affiliation with a religion with strict prohibitions against drinking alcohol and completing high school was associated with lower odds of heavy episodic drinking. The health of minority men in the United States has been neglected, and immigrant Latino men comprise a particularly vulnerable population. This analysis provides initial data on some factors associated with heavy drinking within a population about whom little is known. Future studies should examine moderating or mediating factors between age, acculturation, religiosity, and heavy drinking that might be targets for behavioral interventions

Depressive Symptoms Among Immigrant Latino Sexual Minorities

To estimate the prevalence and identify correlates of depressive symptoms among immigrant Latino sexual minorities

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Efecto de la inclusión follaje fresco de Marango (Moringa oleifera) en la alimentación de conejos en desarrollo, en la Finca Santa Rosa, Managua 2015

Con el objetivo de evaluar el potencial del follaje fresco de Moringa oleifera como alimento para conejos y su efecto sobre el comportamiento productivo , se realizó el presente experimento en la Unidad de Producción cunícola de la Universidad Nacional Agraria. Se utilizaron 18 conejos de razas Neozelandés Blanco y California con una edad de 40 d-1 y un peso promedio de 712.19g(127.96)agrupados en un diseño completamente al azar (DCA) con seis repeticiones por tratamiento, l os tratamientos fueron T1: 100% concentrado comercial , T2: 80% concentrado comercial + 20% follaje de Moringa o leifera, T3: 70% Concentrado + 30% follaje de Moringa o leifera. Las variables evaluadas fueron: consumo de alimento, ganancia de peso, conversión alimenticia, Morfometría del tracto gastrointestinal, características de la canal y análisis sensorial de la carne de conejos, los datos se analizaron mediante el procedimiento de análisis de varianza (ANDEVA),utilizando el Modelo Lineal General del Software MINITAB(Minitab®,versión 16.0, 2012). Los resultados obtenidos muestran que no se encontró diferencias significativas (p>0.05) en el consumo de alimento, ganancia media diaria y conversión alimenticia así mismo para la Morfometría del tracto gastrointestinal sin embargo para el análisi s sensorial de la carne los jueces no entrenados encontraron diferencias en la calidad, textura y diferencias altamente significativas en la dureza(1er mordisco). En el análisis financiero se encontró una mayor utilidad al comparar el T1 vs T3 con US$1.10 seguido por el T1 vs T2 con US$ 0.48

Listening to the Voices of Latina Women: Sexual and Reproductive Health Intervention Needs and Priorities in a New Settlement State in the United States

Latina women in the United States are disproportionately affected by negative sexual and reproductive health outcomes. Our community-based participatory research partnership conducted in-depth interviews exploring sexual and reproductive health needs and priorities with 25 Latinas in North Carolina and identified themes through constant comparison, a grounded theory development approach. Participants described individual-, interpersonal-, and clinic-level factors affecting their sexual and reproductive health as well as potentially successful intervention characteristics. Our findings can be used to inform culturally congruent interventions to reduce sexual and reproductive health disparities among Latinas, particularly in new settlement states in the southeastern United States

A Snapshot of How Latino Heterosexual Men Promote Sexual Health Within Their Social Networks: Process Evaluation Findings from an Efficacious Community-Level Intervention

BACKGROUND: HoMBReS was a community-level social network intervention designed to increase sexual health among Latino heterosexual men who were members of a multi-county soccer league. METHODS: We used process data collected each month during 18 months of intervention implementation from each of 15 trained Latino male lay health advisors (known as Navegantes) to explore the activities that Navegantes conducted to increase condom and HIV testing among their social network members. RESULTS: The Navegantes reported conducting 2,364 activities, for a mean of 8.8 activities per Navegante per month. The most common activity was condom distribution. Most activities were conducted with men; about 2% were conducted with women. Among activities conducted with men, half were conducted with soccer teammates and half with non-teammates. CONCLUSIONS: Latino men’s social networks can be leveraged to promote sexual health within the community. Innovative methods that reach large numbers of community members are needed given the lack of prevention resources for populations disproportionately impacted by HIV and STDs

Pauloabibite, trigonal NaNbO3, isostructural with ilmenite, from the Jacupiranga carbonatite, Cajati, São Paulo, Brazil.

Pauloabibite (IMA 2012-090), trigonal NaNbO3, occurs in the Jacupiranga carbonatite, in Cajati County, São Paulo State, Brazil, associated with dolomite, calcite, magnetite, phlogopite, pyrite, pyrrhotite, ancylite-(Ce), tochilinite, fluorapatite, “pyrochlore”, vigezzite, and strontianite. Pauloabibite occurs as encrustations of platy crystals, up to 2 mm in size, partially intergrown with an unidentified Ca-Nb-oxide, embedded in dolomite crystals, which in this zone of the mine can reach centimeter sizes. Cleavage is perfect on {001}. Pauloabibite is transparent and displays a sub-adamantine luster; it is pinkish brown and the streak is white. The calculated density is 4.246 g/cm3 . The mineral is uniaxial; n(mean)calc is 2.078. Chemical composition (n = 17, WDS, wt%) is: Na2O 16.36, MgO 0.04, CaO 1.36, MnO 0.82, FeO 0.11, SrO 0.02, BaO 0.16, SiO2 0.03, TiO2 0.86, Nb2O5 78.66, Ta2O5 0.34, total 98.76. The empirical formula is (Na0.88Ca0.04Mn2+ 0.02)S0.94(Nb0.98Ti0.02)S1.00O3. X-ray powder-diffraction lines (calculated pattern) [d in Å(I)(hkl)] are: 5.2066(100)(003), 4.4257(82)(101), 3.9730(45)(012), 2.9809(54) (104), 2.3718(88)(213), 1.9865(28)(024), 1.8620(53)(216), and 1.5383(30)(300). It is trigonal, space group: R3, a = 5.3287(5), c = 15.6197(17) Å, V = 384.10(7) Å3 , Z = 6. The crystal structure was solved (R1 = 0.0285, wR2 = 0.0636 for 309 observed reflections). Pauloabibite is isostructural with ilmenite and is polymorphic with isolueshite (cubic) and lueshite (orthorhombic). The name is in honor of Paulo Abib Andery (1922–1976)