Paradoxical Effect of Aspirin

Low-dose aspirin is an important therapeutic option in the secondary prevention of myocardial infarction (MI) and ischemic stroke, basedon its unique cost-effectiveness and widespread availability. In addition, based on the results of a number of large studies, aspirin is also widely used in the primary prevention of MI. This paper provides an update of the available data to offer greater clarity regarding the risks of aspirin with respect to hemorrhagic stroke. In the secondary prevention of cardiovascular, cerebrovascular, and ischemic events, the evidence supports that the benefits of aspirin treatment significantly outweigh the risk of a major hemorrhage. When considering whether aspirin is appropriate, the absolute therapeutic cardiovascular benefits of aspirin must be balanced with the possible risks associated with its use, being hemorrhagic stroke. Regarding these clinical facts, normal, COX 1 −/−, and COX 2 −/− mice were treated with a wide range of doses of aspirin and studied by induced hemorrhagic time. The results outlined three major conclusions: high doses of aspirin induce hemorrhage, while low doses of aspirin do not. In the absence of COX 1, ultra low doses of aspirin produce an antihemorrhagic effect not observed with intermediate doses. The absence of COX 2 induced a hemorrhagic effect that needs further research, probably originated in compensatory phenomena

La drépanocytose en Guadeloupe

BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF

Persistence of Stains and DNA on Evidence in Hostile Situations

In order to exploit DNA evidence, biological liquid must be detected and recovered. It has been suggested that some hostile conditions like a long water soaking period may have an influence on evidence recovery and thus results and interpretation. These researches demonstrate that adapting a protocol for each situation allows to recover any evidence. It still possible to detect and identify blood stain after a washing machine even at 90°C. For semen stain, detection is not possible due to the elimination of the acid phosphatase, but spermatozoa can persist on clothes and a DNA profile can be obtained. Contact cells can be recovered on support which has been immerged in water even several weeks or in contact with fire extinguisher powder or liquid. This study shown that if cells dry enough time to adhere to the support (&gt;1 hour) before water immersion, it is possible to obtain a DNA profile.</p