Field relationships, mineralogy and structural features of the Port Mouton pluton, southwestern Nova Scotia

The Port Mouton pluton (PMP) of southern Nova Scotia is a complex, per aluminous, post-tectonic granitoid body that is distinct from other plutons and batholiths of the Meguma Terrane. The pluton consists of ten units, which collectively range in composition from tonalite to trondhjemite, granodiorite, monzogranite, leucomonzogranite, aplite, pegmatite and lamprophyre. The PMP evolved in three mafic to felsic cycles defined by the initial mafic end-members for each cycle (units 1, 4 and 7). These three units are the most volumetrically abundant of the ten units and unit 1 is the oldest. Shoshonitic lamprophyres intruded mid-way through cycle II and were subsequently intruded by units in cycle III. The PMP is at least 352 Ma (40Ar/39Ar) and is demonstrably younger than the regional metamorphism of 395 Ma. Two distinct foliations observed within the pluton occur only in units 1 and 4. The foliation in unit 1 is perpendicular to the regional foliation of the country rocks and is probably of igneous origin. The local foliation in unit 4, the origin of which remains unknown, is perpendicular to that in unit 1 and parallel to the regional foliation in the country rocks. Contacts of the PMP with the host metasedimentary rocks are predominantly sharp, although minor migmatization is present locally. RÉSUMÉ Le pluton de Port Mouton (PMP) du sud de la Nouvelle-Écosse est une masse granitique complexe, pcralumineuse et post-tectonique, qui se distingue des autres plutons et batholites du terrain de Meguma. Le pluton consiste en dix unités, allant des tonalites aux trondhjemites, granodiorites, monzogranites, leucomonzogranites, aplites, pegmatites et lamprophyres. L'évolution du PMP se divise en trois cycles mafiques à felsiques deTmis par les termes mafiques de chaque cycle (unités 1, 4 et 7). Ces trois unités sont les plus abondantes et l'unité 1 est la plus ancienne. Des lamprophyres shoshonitiques se sont mis en place vers le milieu du cycle II et ont été subséquemment recoupés par les unités du cycle III. Le PMP a un âge minimum de 352 Ma (40Ar/39Ar) mais prédate le métamorphisme régional daté à 395 Ma. Les deux foliations distinctes observéers dans le pluton ne se retxouvent que dans les unités 1 et 4. La foliation dans l’unité 1 est perpendiculaire à la foliation régionale des roches encaissantes et est probablement d’origine ignée. La foliation locale dans l’unité 4, dont l'origine reste obscure, est perpendiculaire à celle de l’unité 1 et est parallèle à la foliation régionale des roches encaissantes. Les contacts du PMP avec les roches métasédimentaires éncaissantes sont principalement nets, bien qu'il y ait de la migmatisation locale. [Traduit par le journal

Patient participation in electronic nursing documentation:An interview study among home-care patients

Abstract Background Patients are increasingly expected to take an active role in their own care. Participation in nursing documentation can support patients to take this active role since it provides opportunities to express care needs and preferences. Yet, patient participation in electronic nursing documentation is not self‐evident. Objective To explore how home‐care patients perceive their participation in electronic nursing documentation. Methods Semi‐structured interviews were conducted with 21 home‐care patients. Interview transcripts were analysed in an iterative process based on the principles of reflexive inductive thematic analysis. Results We identified a typology with four patient types: ‘high need, high ability’, ‘high need, low ability’, ‘low need, high ability’ and ‘low need, low ability’. Several patients felt a need for participation because of their personal interest in health information. Others did not feel such a need since they trusted nurses to document the information that is important. Patients' ability to participate increased when they could read the documentation and when nurses helped them by talking about the documentation. Barriers to patients' ability to participate were having no electronic devices or lacking digital skills, a lack of support from nurses and the poor usability of electronic patient portals. Conclusion Patient participation in electronic nursing documentation varies between patients since home‐care patients differ in their need and ability to participate. Nurses should tailor their encouragement of patient participation to individual patients' needs and abilities. Furthermore, they should be aware of their own role and help patients to participate in the documentation. Patient or Public Contribution Home‐care patients were involved in the interviews

Exploring Subjective Well-being in Older Age by Using Participant-generated Word Clouds

Purpose of the study: Previous research has overlooked the heterogeneity in older adults’ personal conceptions of subjective well-being (SWB), by not taking into account intradomain differences in the conceptions of SWB for different groups of older adults. The aim of this article is therefore to explore (a) older adults’ own views on which aspects, categorized under domains, are important to their SWB and (b) which domains and aspects are important to older adults in different contexts and with different characteristics: to men and women, of different ages, and in different housing arrangements. Design and methods: Sixty-six older adults (aged 65 and older) participated in our study. We asked the participants to freely nominate aspects of SWB that are important to them, using participant-generated word clouds as our exploratory, qualitative data collection method. The data were analyzed using qualitative inductive content analysis. Results: We found 15 domains based on our participants’ conceptions of SWB. The multidimensional domains of social life, activities, health, and space and place were most important to our participants. The domains and aspects were defined and prioritized differently by different groups of participants. Implications: SWB should be studied as a multidimensional, individualized, and contextualized process to generate meaningful empirical information for researchers and policymakers

Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin

A straightforward glycosylation method is described to regio- and stereoselectively introduce two alpha-L-fucose moieties directly to the secondary rim of beta-cyclodextrin. Using NMR and MS fragmentation studies, the nonasaccharide structure was determined, which was also visualized using molecular dynamics simulations. The reported glycosylation method proved to be robust on gram-scale, and may be generally applied to directly glycosylate beta-cyclodextrins to make well-defined multivalent glycoclusters.</p

Do patients’ information needs decrease over the course of radiotherapy?

PURPOSE: We aimed to investigate if cancer patients’ information needs decrease during radiotherapy and if so, which patient, consultation and radiation oncologist characteristics are associated with a decrease in information needs over time. METHODS: In this longitudinal study, patients (n = 104) completed a baseline questionnaire a week before the initial radiotherapy consultation, immediately following this initial consultation, and 1 week prior to the first follow-up visit, which took place on average 3–5 weeks after the initial visit. Besides information needs, measured by the Information Preference for Radiotherapy Patients scale, the questionnaire assessed patient, consultation and radiation oncologist characteristics. RESULTS: Information needs decreased over time, but remained at a high level. Being religious, being male, having low health literacy and higher perceived involvement during the consultation were all statistically significantly associated to a decrease in information needs on specific domains (e.g. procedures or side effects). CONCLUSIONS: Cancer patients’ information needs decline between the initial consultation and the first follow-up visit, but remain high. It is therefore advised to investigate the patients’ information needs at every radiotherapy visit and not rely on giving information just once. Furthermore, radiation oncologists should check if the information given at first consultation is understood and remembered. By those means, tailored information giving becomes possible

Nivolumab and ipilimumab in the real-world setting in patients with mesothelioma

Objectives: Nivolumab (anti-PD-1) plus ipilimumab (anti-CTLA-4) is a new first-line treatment combination for patients with pleural mesothelioma. Nivolumab-ipilimumab improved the survival, however, 30.3% of the patients suffered from grade 3–4 treatment related adverse events (TRAE's) and TRAE's led to discontinuation in 23.0% of all patients. Here, we present the first real-world data of nivolumab plus ipilimumab in patients with malignant mesothelioma treated in two mesothelioma expert centers. Methods: Clinical data of patients with mesothelioma treated with nivolumab and ipilimumab were prospectively collected. Clinical parameters were obtained every visit, CT scans were evaluated every 12 weeks and adverse events were assessed continuously during the treatment. Data on grade 2–5 TRAE's and activity (overall response rate (ORR), duration of response (DOR), disease control rate (DCR), median progression-free survival (mPFS) and median overall survival (mOS) were reported. Results: Between January 2021 and August 2022, 184 patients were treated with nivolumab plus ipilimumab. The median follow-up was 12.1 months (95 %CI 11.1 – 13.1). Grade 3–4 TRAEs were seen in 27.7 % of the patients and 25.0 % discontinued immunotherapy treatment early because of TRAE's. ORR was 21.7 % (95 % CI 15.7–27.7), median DOR was 5.7 months (IQR 3.2–8.7) and DCR at 12 weeks 56.0 % (95 % CI 48.8–63.2). The mPFS was 5.5 months (95 %CI 4.1–6.9), mOS was 14.1 months (95 % CI 11.1–18.2). Conclusions: Nivolumab plus ipilimumab had an equal efficacy in a real-world comparable population but also a high risk of TRAE's, leading to discontinuation of treatment in 25% of the patients.</p