Potential effects of environmental change on mining wastes in a hyperarid climate

Three desert washes were sampled to evaluate the transport of contaminated sediments from abandoned mining sites to downwash environments. The area of concern is an extreme arid climate considered stable and not to pose pathways for contaminated sediments to impact downwash environments. Research of mine wastes in Nelson, Nevada has shown that residual geogenic and anthropogenic trace elements have been mobilized in surface sediments as a result of storm event. Cyanide and trace elements, especially mercury and lead, have transported to 6000 m downwash from source areas. Short term environmental impacts appear to be minimal because of present-day environmental conditions. However, climate shifts caused by the El Nino Southern Oscillations or even a dramatic climate shift might increase regional precipitation promoting a more rapid erosion of contaminated sediment. Currently, wash sediments do not contain levels of CN- or trace elements that pose threats to the environment; however, if erosion and transport of mining waste increased because of additional precipitation, then CN- and trace elements loading in storm water would increase, with their possibly delivery to Lake Mohave

Metta, Mudita, and Metal: Dhamma Instruments in Burmese Buddhism

Bells, gongs, and other dhamma instruments offer valuable insights into the role of sound in Buddhist practice. Participation in musical events in the Theravada Buddhist world is deemed inappropriate for devote laity and for those who have taken monastic vows. The seventh Buddhist precept implores monks “to abstain from dancing, singing, and music,” yet Buddhist monasteries and pagodas are sonically vibrant places that contain a wide variety of layered bells, gongs, chants, and prayers sculpting the sonic environment. This study examines the soundscape of Burmese Buddhist social space and argues that these sounds are essential to understanding the lived practice of Buddhism. After an examination of the construction of gongs, bells, and a variety of dhamma (dharma) instruments in a blacksmith community of southern Mandalay, we follow these instruments to the pagoda and the monastery. Here these instruments are used to mark the acquisition and the distribution of kammic (karmic) merit. Additionally, the sounds that they make are invitations to cultivate particular states of mind, or what the Buddha referred to as the Brahma Viharas, the divine dwelling places of consciousness

Collagen-related biomarkers in severe sepsis: a big stretch?

Biomedical scientists are aggressively investigating biomarkers of disease and injury. The rationale for identifying biomarkers during pathological states, such as severe sepsis, is to improve clinical prognostication and stratify therapeutic interventions for optimal recovery. An added benefit of biomarker studies is knowledge genesis on pathophysiological mechanisms, critical information that provides a basis for hypothesis-driven research. Unfortunately, biomarkers rarely alter our clinical approach in severe sepsis as they are often non-specific, lack adequate sensitivity and/or are difficult to measure and interpret accurately. Given the complexity and heterogeneity of severe sepsis, and the unique genetically derived susceptibilities of individuals, it is highly unlikely that one or even a handful of biomarkers will provide adequate biomedical information for clinical guidance. Thus, biomarkers will ultimately alter clinical decision making only once a panel of promising biomarkers is identified, maximizing sensitivity and specificity, and then adequately scrutinized with quantitative scoring methods over large populations of patients

Diabetic ketoacidosis-associated stroke in children and youth

Diabetic ketoacidosis (DKA) is a state of severe insulin deficiency, either absolute or relative, resulting in hyperglycemia and ketonemia. Although possibly underappreciated, up to 10 of cases of intracerebral complications associated with an episode of DKA, and/or its treatment, in children and youth are due to hemorrhage or ischemic brain infarction. Systemic inflammation is present in DKA, with resultant vascular endothelial perturbation that may result in coagulopathy and increased hemorrhagic risk. Thrombotic risk during DKA is elevated by abnormalities in coagulation factors, platelet activation, blood volume and flow, and vascular reactivity. DKA-associated cerebral edema may also predispose to ischemic injury and hemorrhage, though cases of stroke without concomitant cerebral edema have been identified. We review the current literature regarding the pathogenesis of stroke during an episode of DKA in children and youth. Copyright © 2011 Jennifer Ruth Foster et al

Diabetic Ketoacidosis-Associated Stroke in Children and Youth

Diabetic ketoacidosis (DKA) is a state of severe insulin deficiency, either absolute or relative, resulting in hyperglycemia and ketonemia. Although possibly underappreciated, up to 10% of cases of intracerebral complications associated with an episode of DKA, and/or its treatment, in children and youth are due to hemorrhage or ischemic brain infarction. Systemic inflammation is present in DKA, with resultant vascular endothelial perturbation that may result in coagulopathy and increased hemorrhagic risk. Thrombotic risk during DKA is elevated by abnormalities in coagulation factors, platelet activation, blood volume and flow, and vascular reactivity. DKA-associated cerebral edema may also predispose to ischemic injury and hemorrhage, though cases of stroke without concomitant cerebral edema have been identified. We review the current literature regarding the pathogenesis of stroke during an episode of DKA in children and youth

The Physical Properties of Volcanic and Impact Melt

The emplacement mechanisms of lunar impact melt flows, that form from hypervelocity impact events, have been a subject of debate in the lunar science community, because of their unique physical properties that separate them from other geologic features. Understanding how lunar impact melt flows were emplaced on the surface of the Moon will not only grant us new information about the flow dynamics of impact melt but provide insight into the production and distribution of impact melt and how it built and modified the surfaces of planetary surfaces. Lunar impact melt flows exhibit surface roughness textures and morphologies that are analogous to terrestrial lava flows. For this reason, we seek to quantify the surface roughness of terrestrial lava flows using synthetic aperture radar (SAR) at two localities, Craters of the Moon National Monument and Preserve, Idaho and the 2014-2015 Holuhraun lava flow-field. We focus on using SAR data in this study for two reasons, (1) improve our understanding on how radar surface roughness can be connected to the emplacement mechanisms of volcanic and impact melt, and (2) to highlight the techniques capabilities and limitations for differentiating different lava flow types and lava facies. Impact melt has contrasting intrinsic properties and geologic origins to lava flows, so we include the analysis of a physical property of impact melts that influences melt behaviour. To complement our radar surface roughness analysis, we seek to constrain the temperature of the Mistastin Lake impact structure impact melt deposits by analyzing the crystallographic orientations and microstructures of zircon grains and zirconia crystals encased in melt-bearing impactites. We demonstrate in this work that without entirely understanding the capabilities and limitations of using SAR for lava flow differentiation, we will struggle to interpret the eruption dynamics and history of volcanic landforms on terrestrial bodies, which in turn limits what we can learn about impact melt emplacement. Furthermore, we discover that high temperature and pressure conditions can be constrained from an impact environment that was once superheated, which has strong implications for discovering high P-T shock indicators in other terrestrial impact structures and also in lunar impactites. In addition, our work has strong applications towards addressing high priority science goals established by research groups such as the Lunar Exploration Analysis Group

Significance of active site residues in the n-domain selectivity of angiotensin-converting enzyme

Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays an important role in vascular function; with ACE inhibitors being clinically utilised in the treatment of cardiovascular disease and diabetic nephropathy. Somatic ACE consists of two homologous catalytically active domains (designated N- and C-domains) that share high overall sequence identity and structural topology. Despite the high degree of similarity between domains, each domain displays differences in substrate processing and inhibitor binding abilities. This suggests that active site residues differing between the two domains could provide unique interactions within the N-domain that allow for N-selective binding and processing. Literature reports of ACE crystal structures and studies with substrate and inhibitor analogues have implicated unique residues present in the S2 and S2' subsites in providing important interactions for N-selectivity

Adaptive protocols for mobile ad hoc networks

Recent advances in low-power technologies have resulted in the proliferation of inexpensive handheld mobile computing devices. Soon, just like the Internet empow- ered a whole new world of applications for personal computers, the development and deployment of robust ubiquitous wireless networks will enable many new and exciting futuristic applications. Certain to be an important part of this future is a class of networks known as "mobile ad hoc networks." Mobile ad hoc networks (or simply "ad hoc networks") are local-area networks formed "on the spot" between collocated wireless devices. These devices self-organize by sharing information with their neigh- bors to establish communication pathways whenever and wherever they are. For ad hoc networks to succeed, however, new protocols must be developed that are capable of adapting to their dynamic nature. In this dissertation, we present a number of adaptive protocols that are designed for this purpose. We investigate new link layer mechanisms that dynamically monitor and adapt to changes in link quality, including a protocol that uses common control messages to form a tight feedback control loop for adaptation of the link data rate to best match the channel conditions perceived by the receiver. We also investigate routing protocols that adapt route selection according to network characteristics. In particular, we present two on-demand routing protocols that are designed to take advantage of the presence of multirate links. We then investigate the performance of TCP, showing how communication outages caused by link failures and routing delays can be very detrimental to its performance. In response, we present a solution to this problem that uses explicit feedback messages from the link layer about link failures to adapt TCP's behavior. Finally, we show how link failures in heterogeneous networks containing links with widely varying bandwidth and delay can cause repeated "modal" changes in capacity that TCP is slow to detect. We then present a modifed version of TCP that is capable of more rapidly detecting and adapting to these changes