874 research outputs found
Medical Biochemistry Without Rote Memorization: Multi-Institution Implementation And Student Perceptions Of A Nationally Standardized Metabolic Map For Learning And Assessment
Despite the growing number of patients worldwide with metabolism-related chronic diseases, medical biochemistry education is commonly perceived as focusing on recall of facts irrelevant for patient care. The authors suggest that this focus on rote memorization of pathways creates excessive cognitive load that may interfere with learners’ development of an integrated understanding of metabolic regulation and dysregulation. This cognitive load can be minimized by providing appropriate references during learning and assessment. Biochemistry educators collaborated to develop a medically relevant Pathways of Human Metabolism map (MetMap) that is now being used at many medical schools as a nationally standardized resource during learning and assessments. To assess impact, students from three medical schools were surveyed about its benefits and disadvantages. Responses were obtained from 481 students (84%) and were examined using thematic analysis. Five main themes emerged as perceived benefits of using the MetMap: 1) aids visual and mental organization, 2) promotes deep learning and applied understanding, 3) decreases emphasis on memorization, 4) reduces anxiety on exams, and 5) aids recall. Perceived disadvantages were: 1) fear of under-preparation for licensing exams, 2) overwhelming nature of the map, and 3) reduced motivation for and time spent studying. Results affirm that students perceive use of the MetMap promotes focus on broader metabolic concepts and deep versus surface learning, supporting a shift in cognitive load toward desired goals. Although the long-term impact on learning needs to be further studied, the use of the MetMap represents a step toward open-reference exams that reflect “real world” practice
Transmission of High-Power Electron Beams Through Small Apertures
Tests were performed to pass a 100 MeV, 430 kWatt c.w. electron beam from the
energy-recovery linac at the Jefferson Laboratory's FEL facility through a set
of small apertures in a 127 mm long aluminum block. Beam transmission losses of
3 p.p.m. through a 2 mm diameter aperture were maintained during a 7 hour
continuous run.Comment: arXiv admin note: text overlap with arXiv:1305.019
Measured Radiation and Background Levels During Transmission of Megawatt Electron Beams Through Millimeter Apertures
We report measurements of photon and neutron radiation levels observed while
transmitting a 0.43 MW electron beam through millimeter-sized apertures and
during beam-off, but accelerating gradient RF-on, operation. These measurements
were conducted at the Free-Electron Laser (FEL) facility of the Jefferson
National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an
energy-recovery linear accelerator. The beam was directed successively through
6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a
maximum current of 4.3 mA (430 kW beam power). This study was conducted to
characterize radiation levels for experiments that need to operate in this
environment, such as the proposed DarkLight Experiment. We find that sustained
transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is
feasible with manageable beam-related backgrounds. We also find that during
beam-off, RF-on operation, multipactoring inside the niobium cavities of the
accelerator cryomodules is the primary source of ambient radiation when the
machine is tuned for 130 MeV operation.Comment: 9 pages, 11 figures, submitted to Nuclear Instruments and Methods in
Physics Research Section
Radio sources at low Galactic latitudes
We present high-resolution radio observations of a sample of 65 radio sources
at low Galactic latitudes. The sources were all observed at 5 GHz with the Very
Large Array A-array. MERLIN observations at 5 GHz of the ultracompact HII
region G34.26+0.15 and one of the extragalactic sources, B1857-000, are also
presented, as are GMRT observations of HI in the direction of three sources,
B1801-203, B1802-196 and B1938+229. These observations were made with the
objectives of (i) finding compact components suitable for studying the effects
of interstellar scattering at lower frequencies, (ii) identifying high
surface-brightness lobes of background radio sources to probe the Galactic
magnetic field on different scales via polarization observations, and (iii)
searching for young supernova remnants. We discuss the nature of the sources
found to have shell or shell-like structure and exhibiting both thermal and
non-thermal spectra. Of the remaining sources, B1749-281 is coincident within
the positional errors of a known pulsar, not detected earlier at 5 GHz. The
rest are likely to be background extragalactic objects.Comment: 12 pages, 6 figures (most with multiple images), 1 table. Accepted
for publicaton in MNRA
Mundane objects in the city: Laundry practices and the making and remaking of public/private sociality and space in London and New York
The paper considers how shifting laundry practices and technologies associated with dirty washing have over time summoned different spaces, socialities and socio-spatial assemblages in the city, enrolling different actors and multiple publics and constituting different associations, networks and relations in its wake as it travels from the home and back again. It argues that rather than being an inert object of unpleasant matter, whose encounter with humans has been largely restricted to certain categories of person for its transformation to re-use, and thus passed unnoticed, the paper explores how laundry practices have figured in producing and reproducing gendered (and classed) relations of labour, and enacting multiple socio-spatial, and gendered, relations and assemblages in the city, which have largely gone unnoticed in accounts of everyday urban life
Myocardial Hypertrophy Overrides the Angiogenic Response to Hypoxia
Background: Cyanosis and myocardial hypertrophy frequently occur in combination. Hypoxia or cyanosis can be potent inducers of angiogenesis, regulating the expression of hypoxia-inducible factors (HIF), vascular endothelial growth factors (VEGF), and VEGF receptors (VEGFR-1 and 2); in contrast, pressure overload hypertrophy is often associated with impaired pro-angiogenic signaling and decreased myocardial capillary density. We hypothesized that the physiological pro-angiogenic response to cyanosis in the hypertrophied myocardium is blunted through differential HIF and VEGF-associated signaling. Methods and Results: Newborn rabbits underwent aortic banding and, together with sham-operated littermates, were transferred into a hypoxic chamber (FiO2 = 0.12) at 3 weeks of age. Control banded or sham-operated rabbits were housed in normoxia. Systemic cyanosis was confirmed (hematocrit, arterial oxygen saturation, and serum erythropoietin). Myocardial tissue was assayed for low oxygen concentrations using a pimonidazole adduct. At 4 weeks of age, HIF-1α and HIF-2α protein levels, HIF-1α DNA-binding activity, and expression of VEGFR-1, VEGFR-2, and VEGF were determined in hypoxic and normoxic rabbits. At 6 weeks of age, left-ventricular capillary density was assessed by immunohistochemistry. Under normoxia, capillary density was decreased in the banded rabbits compared to non-banded littermates. As expected, non-hypertrophied hearts responded to hypoxia with increased capillary density; however, banded hypoxic rabbits demonstrated no increase in angiogenesis. This blunted pro-angiogenic response to hypoxia in the hypertrophied myocardium was associated with lower HIF-2α and VEGFR-2 levels and increased HIF-1α activity and VEGFR-1 expression. In contrast, non-hypertrophied hearts responded to hypoxia with increased HIF-2α and VEGFR-2 expression with lower VEGFR-1 expression. Conclusion: The participation of HIF-2α and VEGFR-2 appear to be required for hypoxia-stimulated myocardial angiogenesis. In infant rabbit hearts with pressure overload hypertrophy, this pro-angiogenic response to hypoxia is effectively uncoupled, apparently in part due to altered HIF-mediated signaling and VEGFR subtype expression
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