Fishes of the Mountain Province Section of the Ouachita River

A survey of the fishes of the mountain province section of the Ouachita River from the headwaters to Remmel Dam using field collections, literature records, and museum collections showed the ichthyofauna to be made up of 80 species representing 16 families. Fourteen species not previously reported from the mountain province section of the river were collected in this survey. These species include Ichthyomyzon gagei, Nocomis asper, Notropis ortenburgeri, N. rubellus, Pimephales promelas, Moxostoma carinatum, Noturus taylori, Fundulus notatus, Lepomis humilis, Etheostoma histrio, E. proeliare, Percina maculata, P. nasuta, and P. uranidea. The Nocomis specimens were the first collected from the Ouachita River system and the discovery of Noturus taylori represents a major range extension

A list of the fishes in the Northeast Louisiana University Museum of Zoology

This report (the 15th and final version of a series started in 1964) describes this large collection of preserved specimens of fishes, the history of development and growth of the collection, sources of funding, and the values and uses of its specimens and associated data. Also included is a list of the major specimen contributors (collectors), as well as a list of the type specimens held in the collection. The bulk of the report is a taxonomically organized summary of all specimens in the collection at the time of publication. Subsequent to production of this report, the University of Louisiana Monroe administration announced that it was disposing of this collection, and a National Science Foundation-funded Award (#1745363, August 29, 2017), "RAPID: A regional plan to rescue the orphaned University of Louisiana Monroe Fish Collection" provided the resources to begin distribution of this collection to a consortium of regional fish collections (including Louisiana State University, Southeastern Louisiana University, Arkansas State University, the Mississippi Museum of Natural Science, and University of Texas at Austin. This archive of this previously unpublished report was done as part of the process of accessioning and cataloging those specimens from Texas and surrounding states that came to the University of Texas at Austin.Integrative Biolog

Upper‐level midlatitude troughs in boreal winter have an amplified low‐latitude linkage over Africa

In boreal winter, strong upper-level midlatitude troughs across the Atlantic–Africa–southwestern Asia sector generate substantial tropical–extratropical interaction and have become recognized as important factors in some extreme weather events. As such, they represent important dynamic features to understand and capture in weather forecasts, as well as in climate models for projections on longer timescales. Here, we empirically study the 20% of winter days with strongest trough signatures during 1982–2020 at each longitude across the sector, and show that the trough impact over northern Africa, most notably in central parts, is particularly strong in magnitude, low-latitude extent and persistence, leading to the characterization of a northern Africa mode of several-days weather fluctuation. Weather conditions that follow strong troughs from the eastern Atlantic to the Central Mediterranean include: (i) a warming tendency across much of northern Africa, generally of several Celsius magnitude ahead of the trough, and >1°C even extending to the south of 10° N in central parts and continuing eastward until the Ethiopian Highlands; (ii) precipitation development further north than normal across northern tropical Africa, especially strong over longitudes corresponding to a northward extension of the main Congo rain belt. The intertropical discontinuity and low-level heat low are also shifted significantly north, with the complex of anomalies persisting for several days, beyond the timescale of the trough. For context, at all other trough longitudes across the sector, a warming signal does emerge (statistically significant), but with much shorter persistence (2–3 days), smaller magnitude and extending southward clearly only to 15–20° N. Mid-level tropical plumes of moisture are also typically present for strong troughs from the eastern Atlantic to southwestern Asia, and these alone can lead to weather extremes. However, low-level warming and mid-level moistening are uniquely juxtaposed at low latitudes over central Africa, where a near-equatorial signature develops

The influence of defined ante-mortem stressors on the early post-mortem biochemical processes in the abdominal muscle of the Norway lobster, Nephrops norvegicus (Linnaeus, 1758)

The effects of four different ante-mortem stressors (exercise, emersion, starvation and a patent infection with the parasite Hematodinium sp.) on post-mortem processes have been investigated in the abdominal muscle of Norway lobster Nephrops norvegicus by measuring changes in the pH, the levels of glycogen, l-lactate, arginine phosphate, ATP, ADP, AMP, IMP, HxR, Hx and the adenylate energy charge (AEC) over a time course of 24 h with samples being taken at 0, 3, 6, 12 and 24 h. The acute stresses of intense exercise and 2 h emersion resulted in a premature onset of anaerobic glycolysis, leading both to an enhanced glycogen depletion rate and an early accumulation of l-lactate. The chronic stressors, starvation and parasite infection, resulted in a complete ante-mortem depletion of muscle glycogen and consequently the failure of post-mortem glycolytic fermentation. Post-mortem pH and ATP inter-conversion were significantly altered in chronically stressed animals. Ante-mortem, a rapid, almost complete depletion of arginine phosphate was observed in all stress groups. The AEC was altered significantly by all stresses, indicating a strong energy demand. The findings suggest that ante-mortem stressors strongly influence the post-mortem biochemical processes. The laboratory-based results are compared to 'field' data and effects on post-harvest product quality are discussed

Temporal profiling of the cortical synaptic mitochondrial proteome identifies ageing associated regulators of stability

Synapses are particularly susceptible to the effects of advancing age, and mitochondria have long been implicated as organelles contributing to this compartmental vulnerability. Despite this, the mitochondrial molecular cascades promoting age-dependent synaptic demise remain to be elucidated. Here, we sought to examine how the synaptic mitochondrial proteome (including strongly mitochondrial associated proteins) was dynamically and temporally regulated throughout ageing to determine whether alterations in the expression of individual candidates can influence synaptic stability/morphology. Proteomic profiling of wild-type mouse cortical synaptic and non-synaptic mitochondria across the lifespan revealed significant age-dependent heterogeneity between mitochondrial subpopulations, with aged organelles exhibiting unique protein expression profiles. Recapitulation of aged synaptic mitochondrial protein expression at the Drosophila neuromuscular junction has the propensity to perturb the synaptic architecture, demonstrating that temporal regulation of the mitochondrial proteome may directly modulate the stability of the synapse in vivo

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of prostate carcinoma.

Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer death among men in the United States. In recent years, several new agents, including cancer immunotherapies, have been approved or are currently being investigated in late-stage clinical trials for the management of advanced prostate cancer. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a multidisciplinary panel, including physicians, nurses, and patient advocates, to develop consensus recommendations for the clinical application of immunotherapy for prostate cancer patients. To do so, a systematic literature search was performed to identify high-impact papers from 2006 until 2014 and was further supplemented with literature provided by the panel. Results from the consensus panel voting and discussion as well as the literature review were used to rate supporting evidence and generate recommendations for the use of immunotherapy in prostate cancer patients. Sipuleucel-T, an autologous dendritic cell vaccine, is the first and currently only immunotherapeutic agent approved for the clinical management of metastatic castrate resistant prostate cancer (mCRPC). The consensus panel utilized this model to discuss immunotherapy in the treatment of prostate cancer, issues related to patient selection, monitoring of patients during and post treatment, and sequence/combination with other anti-cancer treatments. Potential immunotherapies emerging from late-stage clinical trials are also discussed. As immunotherapy evolves as a therapeutic option for the treatment of prostate cancer, these recommendations will be updated accordingly