A Hybrid Analysis for Security Protocols with State

Cryptographic protocols rely on message-passing to coordinate activity among principals. Each principal maintains local state in individual local sessions only as needed to complete that session. However, in some protocols a principal also uses state to coordinate its different local sessions. Sometimes the non-local, mutable state is used as a means, for example with smart cards or Trusted Platform Modules. Sometimes it is the purpose of running the protocol, for example in commercial transactions. Many richly developed tools and techniques, based on well-understood foundations, are available for design and analysis of pure message-passing protocols. But the presence of cross-session state poses difficulties for these techniques. In this paper we provide a framework for modeling stateful protocols. We define a hybrid analysis method. It leverages theorem-proving---in this instance, the PVS prover---for reasoning about computations over state. It combines that with an "enrich-by-need" approach---embodied by CPSA---that focuses on the message-passing part. As a case study we give a full analysis of the Envelope Protocol, due to Mark Ryan

GPS Modeling for Designing Aerospace Vehicle Navigation Systems

The complexity of the design of a Global Positioning System (GPS) user segment, as well as the performance demanded of the components, depends on user requirements such as total navigation accuracy. Other factors, for instance the expected satellite/vehicle geometry or the accuracy of an accompanying inertial navigation system can also affect the user segment design. Models of GPS measurements are used to predict user segment performance at various levels. Design curves are developed which illustrate the relationship between user requirements, the user segment design, and component performance

A representative sample of Be stars IV: Infrared Photometry and the Continuum Excess

We present infra-red (JHK) photometry of 52 isolated Be stars of spectral types O9--B9 and luminosity classes III--V. We describe a new method of reduction, enabling separation of interstellar reddening and circumstellar excess. Using this technique we find that the disc emission makes a maximum contribution to the optical (B-V) colour of a few tenths of a magnitude. We find strong correlations between a range of emission lines (H\alpha, Br\gamma, Br11, and Br18) from the Be stars' discs, and the circumstellar continuum excesses. We also find that stellar rotation and disc excess are correlated.Comment: 10 pages, 9 figures, accepted for publication in Astronomy and Astrophysics. Other papers in this series can be obtained at http://cwis.livjm.ac.uk/astro/research/environs.htm

The female protective effect in autism spectrum disorder is not mediated by a single genetic locus

Background: A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; however, the mechanism of such protection is unknown. Quantitative assessment of ASD symptoms using the Social Responsiveness Scale (SRS) shows a bimodal distribution unique to females in multiplex families. This leads to the hypothesis that a single, common genetic locus on chromosome X might mediate the FPE and produce the ASD sex bias. Such a locus would represent a major therapeutic target and is likely to have been missed by conventional genome-wide association study (GWAS) analysis. Methods: To explore this possibility, we performed an association study in affected versus unaffected females, considering three tiers of single nucleotide polymorphisms (SNPs) as follows: 1) regions of chromosome X that escape X-inactivation, 2) all of chromosome X, and 3) genome-wide. Results: No evidence of a SNP meeting the criteria for a single FPE locus was observed, despite the analysis being well powered to detect this effect. Conclusions: The results do not support the hypothesis that the FPE is mediated by a single genetic locus; however, this does not exclude the possibility of multiple genetic loci playing a role in the FPE.Intellectual and Developmental Disabilities Research Center at Washington University (NIH/NICHD) [P30 HD062171]; Simons Foundation (SFARI) [307705]; Canadian Institutes of Health Research; [R01 HD042541]SCI(E)[email protected]; [email protected]

Action Initiation in the Human Dorsal Anterior Cingulate Cortex

The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC to the temporal onset of actions. We studied reactive behavior in patients undergoing therapeutic bilateral cingulotomy to determine the immediate effects of dACC ablation on action initiation. In a simple reaction task, three patients were instructed to respond to a specific visual cue with the movement of a joystick. Within minutes of dACC ablation, the frequency of false starts increased, where movements occurred prior to presentation of the visual cue. In a decision making task with three separate patients, the ablation effect on action initiation persisted even when action selection was intact. These findings suggest that human dACC influences action initiation, apart from its role in action selection

Predictors of web-based follow-up response in the Prevention of Low Back Pain in the Military Trial (POLM)

<p>Abstract</p> <p>Background</p> <p>Achieving adequate follow-up in clinical trials is essential to establish the validity of the findings. Achieving adequate response rates reduces bias and increases probability that the findings can be generalized to the population of interest. Therefore, the purpose of this study was to determine the influence of attention, demographic, psychological, and health status factors on web-based response rates in the ongoing Prevention of Low Back Pain in the Military (POLM) trial.</p> <p>Methods</p> <p>Twenty companies of Soldiers (n = 4,325) were cluster randomized to complete a traditional exercise program including sit-ups (TEP) with or without a psychosocial educational program (PSEP) or a core stabilization exercise program (CSEP) with or without PSEP. A subgroup of Soldiers (n = 371) was randomized to receive an additional physical and ultrasound imaging (USI) examination of key trunk musculature. As part of the surveillance program, all Soldiers were encouraged to complete monthly surveys via email during the first year. Descriptive statistics of the predictor variables were obtained and compared between responders and non-responders using two sample t-tests or chi-square test, as appropriate. Generalized linear mixed models were subsequently fitted for the dichotomous outcomes to estimate the effects of the predictor variables. The significance level was set at .05 a priori.</p> <p>Results</p> <p>The overall response rate was 18.9% (811 subjects) for the first year. Responders were more likely to be older, Caucasian, have higher levels of education and income, reservist military status, non smoker, lower BMI, and have received individualized attention via the physical/USI examination (p < .05). Age, race/ethnicity, education, military status, smoking history, BMI, and whether a Soldier received the physical/USI examination remained statistically significant (p < .05) when considered in a full multivariate model.</p> <p>Conclusion</p> <p>The overall web based response rate during the first year of the POLM trial was consistent with studies that used similar methodology, but lower when compared to rates expected for standard clinical trials. One year response rate was significantly associated with demographic characteristics, health status, and individualized attention via additional testing. These data may assist for planning of future trials that use web based response systems.</p> <p>Trial Registration</p> <p>This study has been registered at reports at <url>http://clinicaltrials.gov</url> (<a href="http://www.clinicaltrials.gov/ct2/show/NCT00373009">NCT00373009</a>).</p

Exploring Glucose Dysregulation in Migraine: Insights from Continuous Glucose Monitoring

Despite being associated with hypoglycemia for nearly a century, a definitive relationship between migraines and glucose dysregulation remains elusive. Accumulating evidence suggests that migraines are in part due to a metabolic mismatch between cerebral demand and available energy. Research analyzing plasma glucose levels and migraine activity may further elucidate this interface between metabolic dysregulation and migraine pathophysiology and may potentially open avenues for therapeutic interventions targeting holistic metabolism for migraine management