SeamlessNeRF: Stitching Part NeRFs with Gradient Propagation

Neural Radiance Fields (NeRFs) have emerged as promising digital mediums of 3D objects and scenes, sparking a surge in research to extend the editing capabilities in this domain. The task of seamless editing and merging of multiple NeRFs, resembling the ``Poisson blending'' in 2D image editing, remains a critical operation that is under-explored by existing work. To fill this gap, we propose SeamlessNeRF, a novel approach for seamless appearance blending of multiple NeRFs. In specific, we aim to optimize the appearance of a target radiance field in order to harmonize its merge with a source field. We propose a well-tailored optimization procedure for blending, which is constrained by 1) pinning the radiance color in the intersecting boundary area between the source and target fields and 2) maintaining the original gradient of the target. Extensive experiments validate that our approach can effectively propagate the source appearance from the boundary area to the entire target field through the gradients. To the best of our knowledge, SeamlessNeRF is the first work that introduces gradient-guided appearance editing to radiance fields, offering solutions for seamless stitching of 3D objects represented in NeRFs.Comment: To appear in SIGGRAPH Asia 2023. Project website is accessible at https://sites.google.com/view/seamlessner

RecolorNeRF: Layer Decomposed Radiance Fields for Efficient Color Editing of 3D Scenes

Radiance fields have gradually become a main representation of media. Although its appearance editing has been studied, how to achieve view-consistent recoloring in an efficient manner is still under explored. We present RecolorNeRF, a novel user-friendly color editing approach for the neural radiance fields. Our key idea is to decompose the scene into a set of pure-colored layers, forming a palette. By this means, color manipulation can be conducted by altering the color components of the palette directly. To support efficient palette-based editing, the color of each layer needs to be as representative as possible. In the end, the problem is formulated as an optimization problem, where the layers and their blending weights are jointly optimized with the NeRF itself. Extensive experiments show that our jointly-optimized layer decomposition can be used against multiple backbones and produce photo-realistic recolored novel-view renderings. We demonstrate that RecolorNeRF outperforms baseline methods both quantitatively and qualitatively for color editing even in complex real-world scenes.Comment: To appear in ACM Multimedia 2023. Project website is accessible at https://sites.google.com/view/recolorner

Effects of Linpan nature therapy on health benefits in older women with and without hypertension

BackgroundNature therapy can significantly benefit the physiology and psychology of middle-aged and older people, but previous studies have focused on forest environments. The restoration potential of rural environments in urban fringe areas, which are more accessible to older people on a daily basis, has not been fully studied. This study assessed the effects of nature therapy on the physical and mental health of older women in a rural setting (locally known as Linpan) in the urban fringe area of Chengdu, China.MethodsWe recruited a total of 60 older women (65.3 ± 5.5 years old) living in cities for 3 days of nature therapy in the winter (30 subjects) and spring (30 subjects), including 20 hypertensive patients.ResultsThe results showed that the overall blood pressure, pulse and sleep dysfunction rating scores of the participants were significantly lower than the pretest levels, and the finger blood oxygen saturation, mid-day salivary alpha-amylase and cortisol were increased post-treatment. Increases in these biomarker indicates and increase in stress. There were significant differences in the changes in systolic blood pressure between the hypertension group (HTN) and the normal group (normal) (HTN decreased by 8.8%, normal decreased by 5.4%), salivary alpha-amylase content (HTN decreased by 0.3%, normal increased by 16.9%), and sleep dysfunction rating scores (HTN decreased by 59.6%, normal decreased by 54%). The decreases in systolic blood pressure and pulse in the winter group were higher than those in the spring group by 1.8 and 4.4%, respectively, while the increases in salivary alpha-amylase content and salivary cortisol content were lower than those in the spring group by 11.7 and 11.2%, respectively, and the decrease in sleep dysfunction rating scores was lower than that in the spring group by 7.1%.ConclusionOur study concluded that nature therapy based on various health activities in the Linpan has significant health effects on older women. It can regulate blood pressure and pulse in older women, relieve cardiovascular disease, improve sleep quality. Meanwhile, older women with high blood pressure experienced a more significant effect than the healthy group

Mitochondrial genome in Hypsizygus marmoreus and its evolution in Dikarya

Background Hypsizygus marmoreus, a high value commercialized edible mushroom is widely cultivated in East Asia, and has become one of the most popular edible mushrooms because of its rich nutritional and medicinal value. Mitochondria are vital organelles, and play various essential roles in eukaryotic cells. Results In this study, we provide the Hypsizygus marmoreus mitochondrial (mt) genome assembly: the circular sequence is 102,752 bp in size and contains 15 putative protein-coding genes, 2 ribosomal RNAs subunits and 28 tRNAs. We compared the mt genomes of the 27 fungal species in the Pezizomycotina and Basidiomycotina subphyla, with the results revealing that H. marmoreus is a sister to Tricholoma matsutake and the phylogenetic distribution of this fungus based on the mt genome. Phylogenetic analysis shows that Ascomycetes mitochondria started to diverge earlier than that of Basidiomycetes and supported the robustness of the hyper metric tree. The fungal sequences are highly polymorphic and gene order varies significantly in the dikarya data set, suggesting a correlation between the gene order and divergence time in the fungi mt genome. To detect the mt genome variations in H. marmoreus, we analyzed the mtDNA sequences of 48 strains. The phylogeny and variation sited type statistics of H. marmoreus provide clear-cut evidence for the existence of four well-defined cultivations isolated lineages, suggesting female ancestor origin of H. marmoreus. Furthermore, variations on two loci were further identified to be molecular markers for distinguishing the subgroup containing 32 strains of other strains. Fifteen conserved protein-coding genes of mtDNAs were analyzed, with fourteen revealed to be under purifying selection in the examined fungal species, suggesting the rapid evolution was caused by positive selection of this gene. Conclusions Our studies have provided new reference mt genomes and comparisons between species and intraspecies with other strains, and provided future perspectives for assessing diversity and origin of H. marmoreus.Ope

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China.Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from 2012 through 2014 at 308 medical centers in mainland China. We collected demographic, medical history, treatment, laboratory, disease severity, and mortality data from all patients. Investigators at each site were asked to complete causality assessments for each case whose diagnosis at discharge was DILI (n=29,478) according to the Roussel Uclaf Causality Assessment Method.Results: Most cases of DILI presented with hepatocellular injury (51.39%; 95% CI, 50.76–52.03), followed by mixed injury (28.30%; 95% CI, 27.73–28.87) and cholestatic injury (20.31%; 95% CI, 19.80–20.82). The leading single classes of implicated drugs were traditional Chinese medicines or herbal and dietary supplements (26.81%) and anti-tuberculosis medications (21.99%). Chronic DILI occurred in 13.00% of the cases and, although 44.40% of the hepatocellular DILI cases fulfilled Hy’s Law criteria, only 280 cases (1.08%) progressed to hepatic failure, 2 cases underwent liver transplantation (0.01%), and 102 patients died (0.39%). Among deaths, DILI was judged to have a primary role in 72 (70.59%), a contributory role in 21 (20.59%), and no role in 9 (8.82%). Assuming the proportion of DILI in the entire hospitalized population of China was represented by that observed in the 66 centers where DILI capture was complete, we estimated the annual incidence in the general population to be 23.80 per 100,000 persons (95% CI, 20.86–26.74). Only hospitalized patients were included in this analysis, so the true incidence is likely to be higher.Conclusions: In a retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China, the annual incidence in the general population was estimated to be 23.80 per 100,000 persons—higher than that reported from western countries. Traditional Chinese medicines, herbal and dietary supplements, and anti-tuberculosis drugs were the leading causes of DILI in mainland Chin

难治性丙型肝炎再认识—谈丙型肝炎抗病毒治疗策略的进展

It has been nearly 20 years from the discovery of hepatitis C virus (HCV) and clinical diagnosis of hepatitis C to antiviral therapy with interferon, and significant progress has been made. Substantial changes have taken place in both the concept and strategy for antiviral treatment of hepatitis C, with more and more direct-acting antiviral agents emerging in recent years; these changes are as follows: from the control of HCV to clinical cure, from a sustained virologic response (SVR) rate around 30% with conventional interferon therapy to an SVR rate of 70-80% with standard therapy with pegylated interferon and ribavirin, and from evaluating the difficulty of treatment based on genotypes and viral load to determining the treatment strategy according to host IL28B genotypes and response patterns (rapid virologic response and complete early virologic response). The progress in antiviral therapy strategies for hepatitis C is systematically reviewed for re-understanding of refractory hepatitis C

Clinical significance of serum HBV RNA measurement in chronic hepatitis B patients

In the era of antiviral therapy with potent nucleos(t)ide analogues (NAs), serum HBV DNA is reduced to a level below the lower limit of detection in most chronic hepatitis B (CHB) patients, but the loss of serum HBV DNA only indicates that reverse transcription of virus is effectively inhibited and cannot truly reflect the transcriptional activity of covalently closed circular DNA (cccDNA) in hepatocytes. In addition, some patients, although with almost depleted or residual, silent cccDNA in liver tissue, were still positive for serum HBsAg after long-term treatment due to the integration of HBV DNA fragments. How to truly evaluate the presence and transcriptional activity of cccDNA in hepatocytes is still a problem that needs to be solved urgently. Serum HBV RNA comes from cccDNA transcript in liver tissue and is released into blood circulation as virus-like HBV RNA particles, since it is not effectively transformed to rcDNA. Therefore, in patients receiving the treatment with NAs, serum HBV RNA can qualitatively reflect the transcriptional activity of cccDNA in liver tissue. At present, most scholars think it is hard to achieve "complete cure" of CHB with current therapies. Therefore, we put forward a ladder-like improvement pattern from "partial cure" to "para-functional cure" and "clinical cure" (or "functional cure"). "Partial cure" based on the elimination or silence of cccDNA and persistently negative HBV RNA should be used to predict the risk of recurrence or virological rebound after drug withdrawal, and a low serum level of HBsAg combined with these two criteria should be used as the criteria for "quasi-clinical cure". The clinical significance of serum HBV RNA measurement needs to be addressed in multi-cohort clinical trails and/or improved in the real world studies

Relationship between Hepatitis B virus infection and platelet production and dysfunction

Hepatitis B virus (HBV) is a kind of hepatotropic DNA virus. The main target organ is liver, except for liver, HBV has been found in a variety of extrahepatic tissues, such as kidney, thyroid, pancreas, bone marrow, etc. HBV can cause severe complications by invading these tissues. Among them, pancytopenia is one of the common complications, especially thrombocytopenia that causes life-threatening bleeding. However, the mechanism of thrombocytopenia is unclear and the treatment is extremely difficult. It has been confirmed that HBV has a close relationship with platelets. HBV can directly infect bone marrow, inhibit platelet production, and accelerate platelet destruction by activating monocyte-macrophage system and immune system. While platelets act as a double-edged sword to HBV. On one hand, the activated platelets can degranulate and release inflammatory mediators to help clear the viruses. Furthermore, platelets can provide anti-fibrotic molecules to improve liver functions and reduce hepatic fibrosis. On the other hand, platelets can also cause negative effects. The infected platelets collect HBV-specific CD8+ T cells and nonspecific inflammatory cells into liver parenchyma, inducing chronic inflammation, liver fibrosis and hepatic carcinoma. This article explores the interaction between HBV infection and platelets, providing a theoretical basis for clinical treatment of thrombocytopenia and severe hemorrhage caused by HBV infection