Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children

OBJECTIVE: Hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. To improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared between adults and children in a Chinese cohort. METHOD: Data from 50 hemophagocytic lymphohistiocytosis patients, including 34 adults and 16 children who fulfilled the 2004 hemophagocytic lymphohistiocytosis diagnostic criteria, were collected and analyzed. RESULTS: 1. Etiological factors: The proportion of Epstein-Barr virus infection was lower in adults compared with children, whereas fungal infection and natural killer/T cell lymphoma were more frequent in adults (

Heterogeneous Myeloid Cells in Tumors

Accumulating studies highlight a critical role of myeloid cells in cancer biology and therapy. The myeloid cells constitute the major components of tumor microenvironment (TME). The most studied tumor-associated myeloid cells (TAMCs) include monocytes, tumor-associated macrophages (TAMs), dendritic cells (DCs), cancer-related circulating neutrophils, tumor-associated neutrophils (TANs), and myeloid-derived suppressor cells (MDSCs). These heterogenous myeloid cells perform pro-tumor or anti-tumor function, exerting complex and even opposing effects on all stages of tumor development, such as malignant clonal evolution, growth, survival, invasiveness, dissemination and metastasis of tumor cells. TAMCs also reshape TME and tumor vasculature to favor tumor development. The main function of these myeloid cells is to modulate the behavior of lymphocytes, forming immunostimulatory or immunosuppressive TME cues. In addition, TAMCs play a critical role in modulating the response to cancer therapy. Targeting TAMCs is vigorously tested as monotherapy or in combination with chemotherapy or immunotherapy. This review briefly introduces the TAMC subpopulations and their function in tumor cells, TME, angiogenesis, immunomodulation, and cancer therapy

A Rapid UAV Image Georeference Algorithm Developed for Emergency Response

The image collection system based on the unmanned aerial vehicle plays an important role in the postearthquake response and disaster investigation. In the postearthquake response period, for hundreds of image stitching or 3D model reconstruction, the traditional UAV image processing methods may take one or several hours, which need to be improved on the efficiency. To solve this problem, the UAV image rapid georeference method for postearthquake is proposed in this paper. Firstly, we discuss the rapid georeference model of UAV images and then adopt the world file designed and developed by ESRI to organize the georeferenced image data. Next, the direct georeference method based on the position and attitude data collected by the autopilot system is employed to compute the upper-left corner coordinates of the georeferenced images. For the differences of image rotation manners between the rapid georeference model and the world file, the rapid georeference error compensation model from the image rotation is considered in this paper. Finally, feature extraction and feature matching for UAV images and referenced image are used to improve the accuracy of the position parameters in the world file, which will reduce the systematic error of the georeferenced images. We use the UAV images collected from Danling County and Beichuan County, Sichuan Province, to implement the rapid georeference experiments employing different types of UAV. All the images are georeferenced within three minutes. The results show that the algorithm proposed in this paper satisfies the time and accuracy requirements of postearthquake response, which has an important application value

Population and housing grid spatialization in Yunnan Province based on grid sampling and application of rapid earthquake loss assessment: the Jinggu Ms6.6 earthquake

Population and housing grid data spatialization based on 340 grid samples (1 km×1 km) is used instead of regional statistical data to simulate the population and housing distribution data of Yunnan Province (1 km×1 km) for rapid loss assessment for the Jinggu Ms6.6 earthquake. The results indicate that the method reflects the actual population and housing distribution and that the assessment results are credible. The method can be used to quickly provide spatial orientation disaster information after an earthquake

Low-Voltage Oxide-Based TFTs Self-Assembled on Paper Substrates With Tunable Threshold Voltage

Oxide-based thin-film transistors (TFTs) with a lateral in-plane electrode are self-assembled on paper substrates, and the electrical modulation effect of the in-plane electrode is investigated. A SiO2-based solid-electrolyte film with high specific capacitance is used as the gate dielectric, and the operation voltage is reduced to less than 2.0 V. The threshold voltage (Vth) of such paper TFTs is tuned from ？0.98 to 0.94 V by different voltage biases on the in-plane electrode. The threshold voltage shift (ΔVth) can be described byΔVth = ？(CG2/CG1)VG2, where CG2 and CG1 are the in-plane electrode and bottom-gate specific capacitance values. High electrical performance with a current on/off ratio of 6 × 105 ～ 106, a subthreshold swing of 0.14 ～ 0.19 V/dec, and a mobility of 8.64 ～ 9.45 cm2/V · s is obtained at different in-plane electrode voltage biases. Such low-voltage paper TFTs are promising for low-cost and portable electronics

Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children

OBJECTIVE: Hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. To improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared between adults and children in a Chinese cohort. METHOD: Data from 50 hemophagocytic lymphohistiocytosis patients, including 34 adults and 16 children who fulfilled the 2004 hemophagocytic lymphohistiocytosis diagnostic criteria, were collected and analyzed. RESULTS: 1. Etiological factors: The proportion of Epstein-Barr virus infection was lower in adults compared with children, whereas fungal infection and natural killer/T cell lymphoma were more frequent in adults (P19 mmol/L and lactate dehydrogenase >500 U/L compared with adults (P<0.05). 3. The time interval from the onset of symptoms to clinical diagnosis was significantly shorter in pediatric patients than in adults (P<0.05). CONCLUSIONS: Certain clinical features were different between the two groups. The less characteristic clinical presentation of hemophagocytic lymphohistiocytosis in adults may make the disease more difficult to diagnose. Our findings suggest that hemophagocytic lymphohistiocytosis should be considered when an adult patient presents with the above-mentioned symptoms