Defective Neurogenesis in Citron Kinase Knockout Mice by Altered Cytokinesis and Massive Apoptosis

AbstractCitron-kinase (Citron-K) has been proposed by in vitro studies as a crucial effector of Rho in regulation of cytokinesis. To further investigate in vivo its biologic functions, we have inactivated Citron-K gene in mice by homologous recombination. Citron-K−/− mice grow at slower rates, are severely ataxic, and die before adulthood as a consequence of fatal seizures. Their brains display defective neurogenesis, with depletion of specific neuronal populations. These abnormalities arise during development of the central nervous system due to altered cytokinesis and massive apoptosis. Our results indicate that Citron-K is essential for cytokinesis in vivo but only in specific neuronal precursors. Moreover, they suggest a novel molecular mechanism for a subset of human malformative syndromes of the CNS

Preliminary Assessment of Radiolysis for the Cooling Water System in the Rotating Target of {SORGENTINA}-{RF}

The SORGENTINA-RF project aims at developing a 14 MeV fusion neutron source featuring an emission rate in the order of 5-7 x 10(13) s(-1). The plant relies on a metallic water-cooled rotating target and a deuterium (50%) and tritium (50%) ion beam. Beyond the main focus of medical radioisotope production, the source may represent a multi-purpose neutron facility by implementing a series of neutron-based techniques. Among the different engineering and technological issues to be addressed, the production of incondensable gases and corrosion product into the rotating target deserves a dedicated investigation. In this study, a preliminary analysis is carried out, considering the general layout of the target and the present choice of the target material

The Surface of the Transneptunian Object 2004 DW

International audienc

ESO Large Programme on Physical Studies of Trans-Neptunian Objects and Centaurs: Visible Spectroscopy

International audienc

The Surface of the Transneptunian Object 2004 DW

International audienc

The Surface of the Transneptunian Object 2004 DW

International audienc

ESO Large Programme on Physical Studies of Trans-Neptunian Objects and Centaurs: Visible Spectroscopy

International audienc

ESO Large Programme on Physical Studies of Trans-Neptunian Objects and Centaurs: Visible Spectroscopy

International audienc

Surface characterization of 28978 Ixion (2001 KX<SUB>76</SUB>)

International audienceThe Plutino 28978 Ixion, one of the largest objects in the Kuiper Belt, is measured by R filter photometry and linear polarimetry over the phase angle range as well as by BVRI colours and visible spectroscopy. Ixion is a medium red object with spectral slope of 17.7%/100 nm (400-900 nm). While its opposition phase curve surge (0.2 mag/deg) is within the typical range found for other solar system objects, it displays unusually high negative polarization (min. -1.3%). Comparison with model spectra and numerical modeling of the opposition brightening and polarization effects suggest an areal mixture of absorbing (dark) and icy (bright) compounds on its surface: the mixing ratio is about 6:1 for dark and bright material of 0.21 and 0.79 single-scattering albedo and of 250 and 33 dimensionless mean free path (length multiplied by wave number), respectively

Alien Registration- Gaoosselin, Mary O. (Augusta, Kennebec County)

https://digitalmaine.com/alien_docs/18929/thumbnail.jp