LOW DOSE RADIATION ADAPTIVE PROTECTION TO CONTROL NEURODEGENERATIVE DISEASES

Concerns have been expressed recently regarding the observed increased DNA damage from activities such as thinking and exercise. Such concerns have arisen from an incomplete accounting of the full effects of the increased oxidative damage. When the effects of the induced adaptive protective responses such as increased antioxidants and DNA repair enzymes are taken into consideration, there would be less endogenous DNA damage during the subsequent period of enhanced defenses, resulting in improved health from the thinking and exercise activities. Low dose radiation (LDR), which causes oxidative stress and increased DNA damage, upregulates adaptive protection systems that may decrease diseases in an analogous manner. Though there are ongoing debates regarding LDR’s carcinogenicity, with two recent advisory committee reports coming to opposite conclusions, data published since the time of the reports have overwhelmingly ruled out its carcinogenicity, paving the way for consideration of its potential use for disease reduction. LDR adaptive protection is a promising approach to control neurodegenerative diseases, for which there are no methods of prevention or cure. Preparation of a compelling ethics case would pave the way for LDR clinical studies and progress in dealing with neurodegenerative diseases

The Risk of Cancer from CT Scans and Other Sources of Low-Dose Radiation: A Critical Appraisal of Methodologic Quality

AbstractIntroduction: Concern exists that radiation exposure from computerized tomography (CT) will cause thousands of malignancies. Other experts share the same perspective regarding the risk from additional sources of low-dose ionizing radiation, such as the releases from Three Mile Island (1979; Pennsylvania USA) and Fukushima (2011; Okuma, Fukushima Prefecture, Japan) nuclear power plant disasters. If this premise is false, the fear of cancer leading patients and physicians to avoid CT scans and disaster responders to initiate forcedevacuations is unfounded.Study Objective: This investigation provides a quantitative evaluation of the methodologic quality of studies to determine the evidentiary strength supporting or refuting a causal relationshipbetween low-dose radiation and cancer. It will assess the number of higher qualitystudies that support or question the role of low-dose radiation in oncogenesis.Methods: This investigation is a systematic, methodologic review of articles published from 1975–2017 examining cancer risk from external low-dose x-ray and gamma radiation, defined as less than 200 millisievert (mSv). Following the PRISMA guidelines, the authors performed a search of the PubMed, Cochrane, Scopus, and Web of Science databases. Methodologies of selected articles were scored using the Newcastle Ottawa Scale (NOS) and a tool identifying 11 lower quality indicators. Manuscript methodologies were rankedas higher quality if they scored no lower than seven out of nine on the NOS and contained no more than two lower quality indicators. Investigators then characterized articles as supporting or not supporting a causal relationship between low-dose radiation and cancer.Results: Investigators identified 4,382 articles for initial review. A total of 62 articles met all inclusion/exclusion criteria and were evaluated in this study. Quantitative evaluation of the manuscripts’ methodologic strengths found 25 studies met higher quality criteria while 37 studies met lower quality criteria. Of the 25 studies with higher quality methods, 21 out of 25did not support cancer induction by low-dose radiation (P = .0003).Conclusions: A clear preponderance of articles with higher quality methods found no increased risk of cancer from low-dose radiation. The evidence suggests that exposure to multiple CT scans and other sources of low-dose radiation with a cumulative dose up to 100 mSv (approximately 10 scans), and possibly as high as 200 mSv (approximately 20 scans), does not increase cancer risk

A Study on Kudal Kirumi

AIM AND OBJECTIVES: AIM: Kudal Kirumi (Worm infestations) is prevalent world wide and more in regions with poor standards of personal and food hygiene and inadequate sanitation. It is said that 40% of world’s population are affected. In tropics expecially children are more prone to infestation due to over crowding and lack of knowledge. The principle aim of study of Kudal Kirumi with clinical study is to collect and review the views and ideas of the ancient Siddhars about this disease, having this basic aim in mind the following aim have been drawn. OBJECTIVE: 1. To make a clinical study on the basis of Siddha Literature. 2. To utilize the diagnostic methods mentioned by the Siddhars. 3. To make a comparative study on Naakkupuchi Noi and Masarai Puzhu Noi regarding their incidence & their effects on age, sex, occupation, etc. 4. To know the extent of correlation of aetiology, signs and symptoms of Naakkupuchi Noi with Ascariasis and Masarai Puzhu Noi with Giardiasis. 5. To use modern parameters in the investigation of the disease that enhances to observe the progress of the patient. 6. To have clinical trial on Kudal Kirumi with Vidangathi Chooranam. 7. To do the Pharmacological and Bio-chemical analysis of the drug. 8. To high light the factors like diet, land climate condition and mainly the hygienic measures in the incidence Naakkupuchi Noi & Masarai Puzhu Noi. 9. To make an awareness about the disease and counselling to the patients about the hygienic life. SUUMARY Infection is most prevalent in tropical and subtropical climates due to lack of sanitary facilities or the use of human faeces as fertilizer (night soil). Infection may also be acquired through ingestion of contaminated fruits and vegetables. Most infected individuals are asymptomatic due to low worm load. Clinical manifestations occur due to intestinal complications. Twenty patients from both sexes of different age groups were selected and a careful detailed history was elicited and diagnosis was made on both the siddha and modern methodology. Among 20 persons 12 were male and 8 were female. The patients were treated with “Vidangathi Chooranam” internally in the in-patient ward of postgraduate Kuzhanthai marathuvam department. Modern investigation also be done. Some of the patients varied in sex, age & in all other respect such as socio-economic status. I took a statistics with the aid of details mentioned in the case sheet. The detailed clinical analysis of the trail drug is done in the Bio- Chemical laboratory in Government siddha medical college, Palayamkottai. The pharmacological analysis of trial drug was done in the dept. of pharmacology in Government Siddha Madical College, Palayamkottai. The drug Vidangathi Chooranam is having good laxative action, very good anti spasmodic action and good antihistamine action. During the course of treatment no signs of complications were reported & recorded. On the basis of clinical results achieved with the evidences of faeces examination at the time of admission and discharge the Vidangathi Chooranam” was proved to be more effective in anthelmintic action for Ascariasis and for Giardiasis, where more than 80% of the cases were completely relieved. CONCLUSION In this clinical study results were found to be satisfactory. Almost the clinical feature of Naakku Puchi correlates with Ascariasis and Masaraipuzhu noi with Giardiasis. The results revealted that the predisposing factors for Naakku Puchi Noi and Masaraipuzhu Noi were contaminated food, unhygienic habits, lack of environmental sanitation and poor socioeconomic condition of the affected person. The trail drug Vidangathi chooranam was effective and given good results in the present research finding show that 80% cases how been completed cured and 20% cases showed moterate relief study. The preparation and administration of the trail drug was very simple economically cheap, easily available. Clinically the drugs are free from adverse effects. So it is concluded that the drug Vidangathi Chooranam was very effective in the treatment of Naakku Puchi Noi and Masaraipuzhu Noi

Croton sparsiflorus whole plant extract mediated biosynthesis of metallic silver nanoparticles and their antibacterial activity

In the present study, the potential of aqueous whole plant extract of Croton sparsiflorus for biosynthesis of silver nanoparticles (AgNPs) was evaluated. The formation of AgNPs was confirmed by color changes and UV- Visible spectroscopy, which showed absorbance maxima peak at 417nm. The scanning electron microscope (SEM) analysis confirmed the particle size and x-ray diffraction (XRD) confirmed the crystalline character of AgNPs. AFM analysis also confirmed the surface morphology of synthesized AgNPs. Fourier transform infrared (FTIR) authorized the presence of alcoholic and phenolic groups played an important reduction role in the synthesis process. It shows the antibacterial efficiency against gram negative bacteria, Klebsiella pneumoniae and Salmonella paratyphi. From the results, it is suggested that green synthesized AgNPs could be used effective in future biomedical engineering. Keywords: Croton sparsiflorus, Green synthesis, Silver nanoparticles, X-ray diffraction, Antibacterial activity

COMMENTARY: ETHICAL ISSUES OF CURRENT HEALTH-PROTECTION POLICIES ON LOW-DOSE IONIZING RADIATION

The linear no-threshold (LNT) model of ionizing-radiation-induced cancer is based on the assumption that every radiation dose increment constitutes increased cancer risk for humans. The risk is hypothesized to increase linearly as the total dose increases. While this model is the basis for radiation safety regulations, its scientific validity has been questioned and debated for many decades. The recent memorandum of the International Commission on Radiological Protection admits that the LNT-model predictions at low doses are “speculative, unproven, undetectable and ‘phantom’.” Moreover, numerous experimental, ecological, and epidemiological studies show that low doses of sparsely-ionizing or sparsely-ionizing plus highly-ionizing radiation may be beneficial to human health (hormesis/adaptive response). The present LNT-model-based regulations impose excessive costs on the society. For example, the median-cost medical program is 5000 times more cost-efficient in saving lives than controlling radiation emissions. There are also lives lost: e.g., following Fukushima accident, more than 1000 disaster-related yet non-radiogenic premature deaths were officially registered among the population evacuated due to radiation concerns. Additional negative impacts of LNT-model-inspired radiophobia include: refusal of some patients to undergo potentially life-saving medical imaging; discouragement of the study of low-dose radiation therapies; motivation for radiological terrorism and promotion of nuclear proliferation