546 research outputs found
Agriculture and health: Agricultural research needs to be better integrated with nutrition and health outcomes
Surgical Video Motion Magnification with Suppression of Instrument Artefacts
Video motion magnification can make blood vessels in surgical video more apparent by exaggerating their pulsatile motion and could prevent inadvertent damage and bleeding due to their increased prominence. It could also indicate the success of restricting blood supply to an organ when using a vessel clamp. However, the direct application to surgical video could result in aberration artefacts caused by its sensitivity to residual motion from the surgical instruments and would impede its practical usage in the operating theatre. By storing the previously obtained jerk filter response of each spatial component of each image frame - both prior to surgical instrument introduction and adhering to a Eulerian frame of reference - it is possible to prevent such aberrations from occurring. The comparison of the current readings to the prior readings of a single cardiac cycle at the corresponding cycle point, are used to determine if motion magnification should be active for each spatial component of the surgical video at that given point in time. In this paper, we demonstrate this technique and incorporate a scaling variable to loosen the effect which accounts for variabilities and misalignments in the temporal domain. We present promising results on endoscopic transnasal transsphenoidal pituitary surgery with a quantitative comparison to recent methods using Structural Similarity (SSIM), as well as qualitative analysis by comparing spatio-temporal cross sections of the videos and individual frames
An intuitive surgical handle design for robotic neurosurgery.
PURPOSE: The expanded endoscopic endonasal approach, a representative example of keyhole brain surgery, allows access to the pituitary gland and surrounding areas through the nasal and sphenoid cavities. Manipulating rigid instruments through these constrained spaces makes this approach technically challenging, and thus, a handheld robotic instrument could expand the surgeon's capabilities. In this study, we present an intuitive handle prototype for such a robotic instrument. METHODS: We have designed and fabricated a surgical instrument handle prototype that maps the surgeon's wrist directly to the robot joints. To alleviate the surgeon's wrist of any excessive strain and fatigue, the tool is mounted on the surgeon's forearm, making it parallel with the instrument's shaft. To evaluate the handle's performance and limitations, we constructed a surgical task simulator and compared our novel handle with a standard neurosurgical tool, with the tasks being performed by a consultant neurosurgeon. RESULTS: While using the proposed handle, the surgeon's average success rate was [Formula: see text], compared to [Formula: see text] when using a conventional tool. Additionally, the surgeon's body posture while using the suggested prototype was deemed acceptable by the Rapid Upper Limb Assessment ergonomic survey, while early results indicate the absence of a learning curve. CONCLUSIONS: Based on these preliminary results, the proposed handle prototype could offer an improvement over current neurosurgical tools and procedural ergonomics. By redirecting forces applied during the procedure to the forearm of the surgeon, and allowing for intuitive surgeon wrist to robot-joints movement mapping without compromising the robotic end effector's expanded workspace, we believe that this handle could prove a substantial step toward improved neurosurgical instrumentation
Mobile applications for weather and climate information: their use and potential for smallholder farmers
Mobile phones are increasingly being used to provide smallholder farmers with agricultural
and related information. There is currently great interest in their scope to communicate
climate and weather information. Farmers consistently identify demand for weather
information and whilst ICTs may be one way of delivering this at scale there are concerns that
this should not be seen as a panacea. At a time when there have been a range of initiatives and
projects that have been implemented this paper seeks to draw lessons and identify key
considerations to inform the development of future mobile applications to provide climate
services to smallholder farmers. A literature review, interviews with key informants and
experts and 15 case study reviews were conducted. This focused principally on Sub Saharan
Africa but included some examples from India.
Despite numerous initiatives few have developed fully beyond the pilot stage and few have
been evaluated. Some of the provision to date has been of questionable value to farmers. A
key observation is that relatively little attention has been paid in design, to the needs for and
use of both the information and technology by farmers, and few attempts made to differentiate
provision according to gender and other demographic variables. Other factors contributing to
success included communications approaches, which are interactive and/or involve trusted
intermediaries who can add context to and help interpret more complex information.
Providing weather information alongside other services as âbundlesâ and in conjunction with
complementary communications approaches appears to work well. An important challenge is
how to meet farmersâ needs for location specific, timely and relevant information in
economically sustainable ways. More widely there are challenges in achieving successful
business models and potential conflicts between initiatives driven by mobile network
operators and public goals.
The study identified areas of considerable potential which include: the use of increasingly
available mobile data connections to ensure locally relevant content is available to farmers in
timely fashion (including both historical climate information and forecasts); development of
participatory decision making tools to enable farmers to interpret information for their own
contexts and consider implications and management options; use of visual applications and
participatory video on mobile devices to enhance learning and advisory services for farmers; the potential for increased feedback between farmers and service providers as well as
increased knowledge sharing between farmers provided by the use of social media
A spherical joint robotic end-effector for the Expanded Endoscopic Endonasal Approach
The endonasal transsphenoidal approach allows surgeons to access the pituitary gland through the natural orifice of the nose. Recently, surgeons have also described an Expanded Endoscopic Endonasal Approach (EEEA) for the treatment of other tumours around the base of the brain. However, operating in this way with nonarticulated tools is technically very difficult and not widely adopted. The goal of this study is to develop an articulated end-effector for a novel handheld robotic tool for the EEEA. We present a design and implementation of a 3.6mm diameter, three degrees-of-freedom, tendon-driven robotic end-effector that, contrary to rigid instruments which operate under fulcrum, will give the surgeon the ability to reach areas on the surface of the brain that were previously inaccessible. We model the end-effector kinematics in simulation to study the theoretical workspace it can achieve prior to implementing a test-bench device to validate the efficacy of the end-effector. We find promising repeatability of the proposed robotic end-effector of 0.42mm with an effective workspace with limits of ±30â, which is greater than conventional neurosurgical tools. Additionally, although the toolâs end-effector has a small enough diameter to operate through the narrow nasal access path and the constrained workspace of EEEA, it showcased promising structural integrity and was able to support approximately a 6N load, despite a large deflection angle the limiting of which is scope of future work. These preliminary results indicate the end-effector is a promising first step towards developing appropriate handheld robotic instrumentation to drive EEEA adoption
Influence of melt feeding scheme and casting parameters during direct-chill casting on microstructure of an AA7050 billet
© The Minerals, Metals & Materials Society and ASM International 2012Direct-chill (DC) casting billets of an AA7050 alloy produced with different melt feeding schemes and casting speeds were examined in order to reveal the effect of these factors on the evolution of microstructure. Experimental results show that grain size is strongly influenced by the casting speed. In addition, the distribution of grain sizes across the billet diameter is mostly determined by melt feeding scheme. Grains tend to coarsen towards the center of a billet cast with the semi-horizontal melt feeding, while upon vertical melt feeding the minimum grain size was observed in the center of the billet. Computer simulations were preformed to reveal sump profiles and flow patterns during casting under different melt feeding schemes and casting speeds. The results show that solidification front and velocity distribution of the melt in the liquid and slurry zones are very different under different melt feeding scheme. The final grain structure and the grain size distribution in a DC casting billet is a result of a combination of fragmentation effects in the slurry zone and the cooling rate in the solidification range
Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury
Craniopharyngioma in children: trends from a third consecutive single-center cohort study
OBJECTIVE: The management of children with craniopharyngioma has evolved over time, with a trend toward less invasive neurosurgical approaches as surgeons have sought to balance oncological control and treatment-related morbidity. To this end, the aim of this study was to evaluate the safety and effectiveness of the current management of children with craniopharyngioma compared to the previous management methods used at the authorsâ treatment center. METHODS: A prospectively maintained database was searched over a 14-year period between January 1, 2005, and December 31, 2018, to identify all children 17 years of age or younger with a new diagnosis of craniopharyngioma. A retrospective case note review was performed for each child to extract data on the presentation, investigation, treatment, and outcome of their illness. Morbidity was assessed in the same fashion as in previous cohorts, according to the following categories: visual loss, pituitary dysfunction, hypothalamic dysfunction, neurological deficits, and cognitive impairment. RESULTS: In total, 59 children were identified with craniopharyngioma during the study period. A total of 92 operations were performed, including cyst drainage (35/92; 38.0%), craniotomy and resection (30/92; 32.6%), and transsphenoidal resection (16/92; 17.4%). Approximately two-thirds of all operations were performed using image guidance (66/92; 71.7%) and one-third were performed using endoscopy (27/92; 29.3%). The majority of children had adjuvant therapy comprising proton beam therapy (18/59; 30.5%) or conventional radiotherapy (16/59; 27.1%). The median follow-up duration was 44 months (range 1â142 months), and approximately one-half of the children had no evidence of residual disease on MRI studies (28/59; 47.5%). Of the remaining 31 children, there was a reduction in the volume of residual disease in 8 patients (8/59; 13.6%), stable residual disease in 18 (18/59; 30.5%), and tumor growth in 5 patients (5/59; 8.5%). There was significantly reduced morbidity (p < 0.05) in all categories in the current cohort compared with our last cohort (1996â2004). CONCLUSIONS: The authorsâ institutional experience of pediatric craniopharyngioma confirms a trend toward less invasive neurosurgical procedures, most of which are now performed with the benefit of image guidance or endoscopy. Moreover, the authors have identified an expanding role for more targeted radiotherapy for children with residual disease. These advances have allowed for tumor control comparable to that achieved in previous cohorts, but with significantly reduced morbidity and mortality
Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection
Histological Evidence of Pulmonary Microthrombosis and Vasculitis in Life-Threatening Respiratory Virus Diseases
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