35 research outputs found

    Assessment of alcohol drinking habits among people with diabetes

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    Wst臋p. Celem pracy by艂a ocena nawyk贸w i wiedzy na temat spo偶ywania alkoholu w艣r贸d os贸b z typem 1 i typem 2 cukrzycy. Materia艂 i metody. Badaniami obj臋to grup臋 140 chorych na cukrzyc臋 typu 1 (ct1) i typu 2 (ct2) hospitalizowanych w Katedrze i Klinice Chor贸b Wewn臋trznych i Diabetologii Uniwersytetu Medycznego w Poznaniu. W艣r贸d os贸b z ct1 by艂o 37 kobiet i 33 m臋偶czyzn, w wieku 35,9 ± 14 lat, ze 艣rednim czasem trwania choroby 15,3 ± 9,9 roku. W grupie os贸b z ct2 by艂y 34 kobiety i 36 m臋偶czyzn w wieku 56,8 ± 10,2 roku, ze 艣rednim czasem trwania choroby 13,1 ± 7,4 roku. W analizowanej grupie przeprowadzono badanie ankietowe dotycz膮ce preferencji i nawyk贸w w zakresie spo偶ycia alkoholu, poziomu wiedzy (w tym wp艂ywu alkoholu na glikemi臋), uczestnictwa w edukacji i aspektu emocjonalnego w zakresie spo偶ycia alkoholu. Wyniki. Spo艣r贸d 140 os贸b 96 respondent贸w (68%) deklarowa艂o spo偶ycie alkoholu. Analiza danych wykaza艂a, 偶e spo偶ycie alkoholu cz臋艣ciej deklaruj膮 osoby z ct1 ni偶 ct2 (83 v. 54%, p = 0,002). Znajomo艣膰 wp艂ywu alkoholu na glikemi臋 mia艂o 67% pacjent贸w z ct1 i 58% z ct2. Osoby spo偶ywaj膮ce alkohol kr贸cej chorowa艂y na cukrzyc臋 w por贸wnaniu z niepij膮cymi (p = 0,02), cz臋艣ciej uczestniczy艂y w zaj臋ciach edukacyjnych (p = 0,03), by艂y m艂odsze (p = 0,02) i cz臋艣ciej by艂y p艂ci m臋skiej (p = 0,01). Wnioski. Wiedza na temat spo偶ywania alkoholu w艣r贸d chorych na cukrzyc臋 w obu typach tego schorzenia jest podobna i jest niezadowalaj膮ca. W艣r贸d badanych cz臋艣ciej deklaracj臋 spo偶ywania alkoholu sk艂ada艂y osoby: m艂odsze, p艂ci m臋skiej, choruj膮ce na cukrzyc臋 typu 1, z kr贸tszym okresem rozpoznania choroby.Introduction. The aim of this study was to assess the habits and knowledge about alcohol use among people with type 1 and type 2 diabetes. Material and methods. The study included a group of 140 patients with type 1 diabetes (DM1) and type 2 (DM2) hospitalized at the Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences. The study group consisted of 70 DM1 patients (37 women and 33 men), aged 35.9 ± 14.0 years, with mean disease duration 15.3 ± 9.9 years and 70 DM2 subjects (34 women and 36 men), aged 5.8 ± 10.2 years, with diabetes duration 13.1 ± 7.4 years. In the study group we conducted a survey on the preferences and habits of alcohol consumption, the level of knowledge (including the effect of alcohol on blood glucose levels), participation in education and emotional aspects of alcohol consumption. Results. Of the 140 patients 96 respondents (68%) reported alcohol consumption, Analysis of the data showed that alcohol consumption often declare patients with DM1 than DM2 (83 vs. 54%, p = 0.002). Knowledge of the effect of alcohol on blood glucose levels had 67% of DM1 patients and 58% of DM2 subjects. Responders who declared alcohol consumption as compared to nondrinkers had shorter duration of diabetes (p = 0.02), more likely participated in educational activities (p = 0.03), were younger (p = 0.02) and more likely to be male (p = 0.01). Conclusions. Knowledge of alcohol consumption among patients with diabetes in both types of the disease is similar and is unsatisfactory. Declaration of alcohol consumption in the study group is associated with male sex, younger age, type 1 diabetes and shorter duration of the disease

    Nanokapsu艂y typu rdze艅-otoczka na bazie chitozanu

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    N-dodecyl derivative of cationically modified chitosan was used to prepare core-shell nanocapsules templated on liquid cores. Surfactant-free method based on ultrasound-assisted direct emulsification of aqueous solution of polysaccharide with oleic acid was applied. Formation of spherical capsules was confirmed by scanning and transmission electron microscopies. Dynamic light scattering measurements were used to determine physicochemical parameters of the obtained particles as well as to follow the process of multilayer shell formation. Confocal microscopy was applied to examine the ability of encapsulation of hydrophobic compounds inside the cores of the nanocapsules. Performed studies confirmed that hydrophobically modified cationic chitosan provides long-term stabilization of oil-in-water emulsion for biomedical applications as no toxic effect was observed in acute oral toxicity studies.Do przygotowania nanokapsu艂 na ciek艂ych rdzeniach stabilizowanych bez u偶ycia ma艂ocz膮steczkowych surfaktant贸w u偶yto N-dodecylowej pochodnej zmodyfikowanego kationowo chitozanu. Kapsu艂y otrzymano w procesie wspomaganej ultrad藕wi臋kami bezpo艣redniej emulsyfikacji fazy wodnej zawieraj膮cej modyfikowany polisacharyd oraz kwas oleinowy. Powstawanie sferycznych kapsu艂 potwierdzono za pomoc膮 skaningowej oraz transmisyjnej mikroskopii elektronowej. Obrazowanie z u偶yciem mikroskopii konfokalnej pos艂u偶y艂o natomiast do zbadania zdolno艣ci do enkapsulacji hydrofobowych barwnik贸w w rdzeniach chitozanowych nanokapsu艂. Stosuj膮c technik臋 dynamicznego rozpraszania 艣wiat艂a wyznaczono fizykochemiczne parametry nanoemulsji oraz stwierdzono powstawanie wielowarstwowych otoczek. Przeprowadzone badania dowiod艂y, 偶e zastosowanie hydrofobowo zmodyfikowanej kationowej pochodnej chitozanu pozwala na uzyskanie stabilnych w czasie emulsji typu olej w wodzie. Wykazany brak toksyczno艣ci uk艂ad贸w w warunkach in vivo pozwala na ich zastosowanie do cel贸w biomedycznych

    Photonics in drug delivery

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    Homogeneous Embedding of Magnetic Nanoparticles into Polymer Brushes during Simultaneous Surface-Initiated Polymerization

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    Here we present a facile and efficient method of controlled embedding of inorganic nanoparticles into an ultra-thin (<15 nm) and flat (~1.0 nm) polymeric coating that prevents unwanted aggregation. Hybrid polymer brushes-based films were obtained by simultaneous incorporation of superparamagnetic iron oxide nanoparticles (SPIONs) with diameters of 8–10 nm into a polycationic macromolecular matrix during the surface initiated atom transfer radical polymerization (SI-ATRP) reaction in an ultrasonic reactor. The proposed structures characterized with homogeneous distribution of separated nanoparticles that maintain nanometric thickness and strong magnetic properties are a good alternative for commonly used layers of crosslinked nanoparticles aggregates or bulk structures. Obtained coatings were characterized using atomic force microscopy (AFM) working in the magnetic mode, secondary ion mass spectrometry (SIMS), and X-ray photoelectron spectroscopy (XPS)

    Hybrid photosensitizer based on halloysite nanotubes for phenol-based pesticide photodegradation

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    The paper describes the studies on the photodecomposition of 4-n-nonylphenol (NP), a widely used pesticide and endocrine disrupting agent. For this purpose a new hybrid photosensitizer (RB-HNT) was obtained composed of Rose Bengal (RB) incorporated into the halloysite nanotubes (HNT). The photosensitizer was characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), confocal microscopy, as well as UV-Vis and fluorescence spectroscopies. The results confirmed that the crystalline structure of HNTs was preserved after modification with RB. The obtained hybrid material efficiently adsorbs hydrophobic compounds. It was also found to be an efficient photosensitizer for singlet oxygen generation. RB-HNT combines the advantages of both of its components, i.e., the ability to adsorb hydrophobic pollutants, which is characteristic for HNT, and photocatalytic properties of RB. Photooxidation kinetics of n-nonylphenol in the presence of RB-HNT and in the aqueous solution of RB were followed spectrophotometrically and compared. The photooxidation in the presence of Bengal Rose followed the first order kinetics, while in the presence of sensitizer (RB-HNT) observed zero-order kinetics. Furthermore the pesticide oxidation by the hybrid catalyst was found to be more efficient. The products formed after various irradiation times were identified by the GCMS analysis and the photodegradation pathway has been proposed
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