The Melting ‘Crown of the Continent’: Visual History of Glacier National Park

Glacier National Park (GNP), located in northwest Montana, US, was signed into existence on 11 May 1910 by then President William Howard Taft. Conservationist George Bird Grinnell was instrumental in lobbying for the park’s creation and negotiated the sale with the Blackfeet Indians. As an editor of the outdoor magazine Field and Stream, Grinnell learned about the region from writer James Willard Schultz and made his first visit there in 1885. Enticed and amazed by the glaciers of the area, the high Rocky Mountain alpine terrain, and the flora and fauna that thrived here, Grinnell advocated for the creation of the park, nicknaming it the “Crown of the Continent.” Grinnell recognized glaciers as a geological wonder. As historian Gerald Diettert records in his 1992 book, Grinnell called the glaciers the “jewels” in the crown. Setting aside land to enjoy the glaciers seemed like a logical means to conserve the landscapes and ecosystems that they supported. Yet today, just about a hundred years from when the park was founded, the glaciers that form GNP’s snow-capped crown are close to extinction. [excerpt

Integration of bioinformatic predictions and experimental data to identify circRNA-miRNA associations

Circular RNAs (circRNAs) have recently emerged as a novel class of transcripts, characterized by covalently linked 3′–5′ ends that result in the so-called backsplice junction. During the last few years, thousands of circRNAs have been identified in different organisms. Yet, despite their role as disease biomarker started to emerge, depicting their function remains challenging. Different studies have shown that certain circRNAs act as miRNA sponges, but any attempt to generalize from the single case to the “circ-ome” has failed so far. In this review, we explore the potential to define miRNA “sponging” as a more general function of circRNAs and describe the different approaches to predict miRNA response elements (MREs) in known or novel circRNA sequences. Moreover, we discuss how experiments based on Ago2-IP and experimentally validated miRNA:target duplexes can be used to either prioritize or validate putative miRNA-circRNA associations

Computational Methods for the Integrative Analysis of Genomics and Pharmacological Data

Since the pioneering NCI-60 panel of the late'80's, several major screenings of genetic profiling and drug testing in cancer cell lines have been conducted to investigate how genetic backgrounds and transcriptional patterns shape cancer's response to therapy and to identify disease-specific genes associated with drug response. Historically, pharmacogenomics screenings have been largely heterogeneous in terms of investigated cell lines, assay technologies, number of compounds, type and quality of genomic data, and methods for their computational analysis. The analysis of this enormous and heterogeneous amount of data required the development of computational methods for the integration of genomic profiles with drug responses across multiple screenings. Here, we will review the computational tools that have been developed to integrate cancer cell lines' genomic profiles and sensitivity to small molecule perturbations obtained from different screenings

Pengaruh Metode Diskusi Menggunakan Aplikasi Zoom Terhadap Hasil Belajar Mahasiswa

Abstract The purpose of this study is to find out the influence of discussion methods using zoom applications during the covid-19 pandemic on the results of learning brake steering courses and suspensions in the Department of Automotive Engineering Faculty of Engineering, State University of Padang. This study consisted of two sample classes, of which one class was an experimental class of 17 people and another class of 17 people as a control class. Discussion methods using zoom apps taught in experimental classes, while the control class without using the zoom-assisted discussion method, control class uses only e-learning platform as experimental class also uses. Sampling research using incidental sampling techniques. Data analysis to test hypotheses using T-test. Before the data is analyzed, conducted in advance descriptive analysis and test of analysis requirements (homogeneity test and normality test). The results prove that there is an influence of discussion methods using zoom applications on the learning outcomes of brake steering courses and suspensions. Keywords : Discussion Method, Zoom, Learning Outcomes, Covid 19 Abstrak Tujuan penelitian ini adalah untuk mengetahui pengaruh metode diskusi menggunakan aplikasi zoom pada masa pandemi covid-19 terhadap hasil belajar mata kuliah kemudi rem dan suspensi di Jurusan Teknik Otomotif Fakultas Teknik Universitas Negeri Padang. Penelitian ini terdiri dari dua kelas sampel, dimana satu kelas merupakan kelas eksperimen yang berjumlah 17 orang dan satu kelas lagi berjumlah 17 orang sebagai kelas kontrol. Metode diskusi menggunakan aplikasi zoom diajarkan pada kelas eksperimen, sedangkan kelas kontrol tanpa menggunakan metode diskusi berbantu zoom, kelas kontrol hanya menggunakan platform e-learning sebagaimana kelas eksperimen juga menggunakannya. Pengambilan sampel penelitian menggunakan teknik sampling incidental. Analisis data untuk menguji hipotesis menggunakan uji-T. Sebelum data dianalisis, dilakukan terlebih dahulu analisis deskriptif dan uji persyaratan analisis (uji homogenitas dan uji normalitas). Hasil penelitian membuktikan bahwa terdapat pengaruh metode diskusi menggunakan aplikasi zoom terhadap hasil belajar mata kuliah kemudi rem dan suspensi. Kata Kunci : Metode Diskusi, Zoom, Hasil Belajar, Covid 1

Analisis Pendapatan USAhatani pada Kopi Tradisional dan Kopi Sambung di Desa Lubuk Kembang, Kec. Curup Utara, Kab. Rejang Lebong

This research was conducted in the Desa Lubuk kembang, Kec. Curup Utara, Kab. Rejang Lebong, Prov. Bengkulu. The purpose of this study are: 1) to calculate revenue on the traditional coffee farming and grafting coffee farming and 2) to determine the condition of efficiency in traditional coffee farming and grafting coffee farming and their difference. The amount of 68 farmers of coffee were chosen by using the accidental sampling method. The respondents of farmers\u27 group consist of 34 farmers. Data analysis used descriptive analysis. The results of this research showed that the average income of traditional coffee farming is Rp. 7,369,461,00/hectar/year, while the average farm income of grafting coffee farming of Rp. 18,792,149/hectar/ year. The average value of R/C ratio in traditional coffee farming was 3.37, while in grafting coffee farming was 3.85. These indicataed that coffe farming, both on traditional coffee farming and grafting coffee farming, were eficient

Effect of Daily Self-weighing on Weight Loss in Adults

Limited experimental evidence has examined the impact of daily self-weighing on weight loss and psychological outcomes. The purpose of this dissertation was to assess the effect of daily self-weighing on weight loss, behavioral, and psychological outcomes among overweight and obese adults using an experimental design and robust analytic methods. This dissertation followed three aims. Aim 1 consisted of a secondary data analysis among participants enrolled in a 12-month Internet-based weight loss intervention to examine the association between daily weighing and weight loss and explore whether diet and physical activity behaviors explain that relationship. Those who reported daily weighing had greater percent weight loss compared to those who reported less frequent weighing at 6 months [(8.27% (5.40) vs. 5.51% (5.41); p=.003] and 12 months [8.09% (7.81) vs. 4.60% (6.35); p=.004]. At 6 months, multiple mediation analysis showed that eating and exercise behaviors acted as mediators between daily self-weighing and weight loss. At 12 months, only eating behaviors explained the relationship. Aim 2 included a randomized controlled trial (n=91) comparing a 6-month low-intensity, daily self-weighing intervention to a delayed intervention control group that included an objective measure of self-weighing. On average, the intervention group self-weighed more days per week (6.1±1.1 vs. 1.1±1.5; p<.0001) and lost significantly more weight compared to the control group [Mean (95%CI); 3 months: -4.41%(-5.5, -3.3) iv vs. -0.37%(-1.5, .76); 6 months: -6.55%(-7.7, -5.4) vs. -0.35%(-1.5, .79); group x time interaction: p<.001]. At 6 months, a greater percentage of the intervention group achieved 5% (42.6% vs. 6.8%; p<.0001) and 10% weight loss (27.7% vs. 0%; p<.0001). Aim 3 examined the psychological effects of the daily self-weighing intervention compared to controls. There were no significant differences between groups in depressive symptoms, anorectic cognitions, disinhibition, susceptibility to hunger, and binge eating. At 6 months, there was a significant group by time interaction for both body dissatisfaction (p=.007) and dietary restraint (p<.001) with the intervention group reporting improved outcomes on these constructs. The results of this dissertation indicate that daily self-weighing is a feasible and effective behavior for weight loss among overweight and obese adults that does not lead to adverse psychological outcomes.Doctor of Philosoph