The combinatorics of interval-vector polytopes

An \emph{interval vector} is a $(0,1)$-vector in $\mathbb{R}^n$ for which all the 1's appear consecutively, and an \emph{interval-vector polytope} is the convex hull of a set of interval vectors in $\mathbb{R}^n$. We study three particular classes of interval vector polytopes which exhibit interesting geometric-combinatorial structures; e.g., one class has volumes equal to the Catalan numbers, whereas another class has face numbers given by the Pascal 3-triangle.Comment: 10 pages, 3 figure

Enseñanza y Tecnologías en el Nivel Superior: La “enseñanza aumentada” y el “docente global”

This paper examines the influence of information and communication technologies on Higher Education. This study aims to identify the impact of the technological evolution on distance education programs and on designing, implementing and evaluating them, which significantly impact on the students. Our hypothesis is that technological evolution – from web 1.0 to web 2.0 – has become techno-pedagogical evolution. This is expressed in the design of a new form of distance education for Higher Education; a modality which we called “Web Blended-Learning” (WB-Learning), that overcomes the “Blended-Learning” (B-Learning). As a result of the analysis, we argue that on the one side, the emergence of new technological environments has helped to enrich and deepen the teaching programs, phenomenon we call “Augmented Teaching”. On the other side, we maintain that those environments challenge the teacher and set a new role, which we call “The Global Teacher”.El propósito de este trabajo es señalar el impacto de la evolución tecnológica sobre las propuestas de enseñanza a distancia en el nivel superior, como así también el valor de la misma a la hora de diseñar, implementar y evaluar propuestas que impactan de manera significativa en sus destinatarios. La hipótesis que proponemos es que la evolución tecnológica ha devenido evolución tecno- pedagógica y se expresa en el diseño de una nueva organización de la enseñanza a distancia para el nivel superior, en una modalidad que hemos denominado Web Blended-Learning (WB-Learning) superadora de la denominada Blended-Learning (B-Learning). Como resultado del análisis sostendremos, por un lado, que el surgimiento de los nuevos entornos tecnológicos ha contribuido a enriquecer y profundizar la propuesta de enseñanza, fenómeno al que denominamos “enseñanza aumentada”; por el otro, dichos entornos desafían al docente y configuran un nuevo rol, al que denominamos “el docente global”

On Picard Groups of Perfectoid Covers of Toric Varieties

Let $X$ be a proper smooth toric variety over a perfectoid field of prime residue characteristic $p$. We study the perfectoid space $\mathcal{X}^{perf}$ which covers $X$ constructed by Scholze, showing that $\text{Pic}(\mathcal{X}^{perf})$ is canonically isomorphic to $\text{Pic}(X)[p^{-1}]$. We also compute the cohomology of line bundles on $\mathcal{X}^{perf}$ and establish analogs of Demazure and Batyrev-Borisov vanishing. This generalizes the first author's analogous results for "projectivoid space".Comment: 24 pages, comments are welcom

El método micro-textual como herramienta de análisis de foros en línea en contextos multiculturales

In this paper, we present the micro-textual method as an efficient analysis tool for the research that is being conducted about online teaching and multiculturalism in higher education, in Melton Centre for Jewish Education in the Hebrew University of Jerusalem. The aim of this paper is to show how the method allows to identify and characterize different types of dialogues in online forums, and to examine their evolution. The method consists of a toolbox of terms that was developed for the analysis of texts. The aim of the method is to contribute to the understanding of textual and intertextual discourse and its evolution in virtual courses, particularly in higher education. This method uses textual and contextual components for the understanding of texts. The ethno-cultural indicator is a main component and it is related to the participant’s membership in a religious or cultural group, and to issues related to its identity. Through the example that was chosen for this work, we propose to analyze questions related to the interrelationship among personal, professional and ethno-cultural indicators, as well as the role of the teacher in online higher education.En este trabajo presentaremos el método micro-textual, como una herramienta eficiente de análisis en la investigación que se está desarrollando sobre enseñanza en línea y multiculturalidad en la Educación Superior, en el Centro Melton de Educación Judía de la Universidad Hebrea de Jerusalem. El propósito del trabajo es mostrar de qué manera el método posibilita identificar y caracterizar diferentes tipos de diálogo en los foros en línea, y asimismo examinar su evolución.El método está constituido por una batería conceptual desarrollada para el análisis de textos y su objetivo es contribuir a la comprensión del discurso textual e intertextual y su evolución en cursos virtuales, en particular en la enseñanza superior. El mismo utiliza componentes textuales y contextuales para la comprensión de textos, siendo un componente central el indicador etno-cultural, vinculado a la pertenencia del participante a un grupo religioso o cultural, y a problemáticas relacionadas con su identidad. En la ejemplificación elegida para este trabajo, propondremos analizar cuestiones vinculadas a la interrelación entre los indicadores personales, profesionales y los etno-culturales; así como también al rol del docente en la educación superior en línea

La dimensión ideológico-identitaria en un proyecto multicultural de educación museal

The Multicultural Museum Project addresses two major challenges of multicultural education: first, improving intercultural relations (particularly between the majority and minorities); second, the respect, appreciation and legitimization of minority cultures. The Interactive Jewish Museum of Chile, on which this article is based, was conceived as a project taking into consideration these two components. This article contains an account of a research describing some aspects of this model's development process, as perceived from the perspectives of different educational visions and conceptions of those who took part in it. Throughout the article we describe the theoretical and methodological assumptions that formed the basis for the development and consolidation of the Interactive Museum project, as well as the first results of the analysis of in-depth interviews conducted with some of its actors. A preliminary analysis of the data allowed us to identify three museal profiles in the development of the educational model: the academic-educational profile, the artistic- multimedial profile, and the ethno-cultural profile. Our findings suggest that, in both the developed museum education model and the educational concept of the museum, the ideological-identity dimension plays a prominent role.El proyecto de educación museal multicultural se inserta en el marco del modelo de educación asentado básicamente en dos ejes: en primer lugar, el mejoramiento de las relaciones interculturales (en particular, entre mayoría y minorías); en segundo lugar, el respeto, la valoración y legitimación de las culturas minoritarias. El Museo Interactivo Judío de Chile, en el que se basa este artículo, fue pensado como un proyecto que toma en cuenta estos dos ejes. Este artículo da cuenta de una investigación en la cual nos proponemos relatar algunos aspectos del proceso de desarrollo de este modelo, desde las diferentes visiones y concepciones educativas de quienes formaron parte del mismo. A lo largo del mismo, daremos cuenta de los supuestos teóricos y metodológicos sobre los cuales se consolidó el desarrollo del proyecto del Museo Interactivo, así como de los primeros resultados derivados del análisis de las entrevistas en profundidad llevadas a cabo con algunos de sus actores. En una primera aproximación al análisis de los datos, pudimos identificar tres perfiles museales en el desarrollo del modelo educativo: el perfil académico-educativo (PAE), el perfil artístico-multimedial (PAM) y el perfil etno-cultural (PEC). Nuestras conclusiones preliminares sugieren que, en el modelo de educación museal desarrollado así como en la concepción educativa del museo, la dimensión ideológico-identitaria juega un rol destacado

Comparison of the Standardized Video Interview and Interview Assessments of Professionalism and Interpersonal Communication Skills in Emergency Medicine

ObjectivesThe Association of American Medical Colleges Standardized Video Interview (SVI) was recently added as a component of emergency medicine (EM) residency applications to provide additional information about interpersonal communication skills (ICS) and knowledge of professionalism (PROF) behaviors. Our objective was to ascertain the correlation between the SVI and residency interviewer assessments of PROF and ICS. Secondary objectives included examination of 1) inter‐ and intrainstitutional assessments of ICS and PROF, 2) correlation of SVI scores with rank order list (ROL) positions, and 3) the potential influence of gender on interview day assessments.MethodsWe conducted an observational study using prospectively collected data from seven EM residency programs during 2017 and 2018 using a standardized instrument. Correlations between interview day PROF/ICS scores and the SVI were tested. A one‐way analysis of variance was used to analyze the association of SVI and ROL position. Gender differences were assessed with independent‐groups t‐tests.ResultsA total of 1,264 interview‐day encounters from 773 unique applicants resulted in 4,854 interviews conducted by 151 interviewers. Both PROF and ICS demonstrated a small positive correlation with the SVI score (r = 0.16 and r = 0.17, respectively). ROL position was associated with SVI score (p < 0.001), with mean SVI scores for top‐, middle‐, and bottom‐third applicants being 20.9, 20.5, and 19.8, respectively. No group differences with gender were identified on assessments of PROF or ICS.ConclusionsInterview assessments of PROF and ICS have a small, positive correlation with SVI scores. These residency selection tools may be measuring related, but not redundant, applicant characteristics. We did not identify gender differences in interview assessments.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150548/1/aet210346_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150548/2/aet210346.pd

What to feed or what not to feed‑that is still the question

INTRODUCTION : This review addresses metabolic diversities after grain feeding of cattle using artificial total mixed ration (TMR), in place of pasture-based feeding. OBJECTIVES : To determine how grain feeding impairs the deuterium-depleting functions of the anaplerotic mitochondrial matrix during milk and meat production. METHODS : Based on published data we herein evaluate how grain-fed animals essentially follow a branched-chain amino acid and odd-chain fatty acid-based reductive carboxylation-dependent feedstock, which is also one of the mitochondrial deuterium-accumulating dysfunctions in human cancer. RESULTS It is now evident that food-based intracellular deuterium exchange reactions, especially that of glycogenic substrate oxidation, are significant sources of deuterium-enriched (2H; D) metabolic water with a significant impact on animal and human health. The burning of high deuterium nutritional dairy products into metabolic water upon oxidation in the human body may contribute to similar metabolic conditions and diseases as described in state-of-the-art articles for cows. Grain feeding also limits oxygen delivery to mitochondria for efficient deuterium-depleted metabolic water production by glyphosate herbicide exposure used in genetically modified crops of TMR constituents. CONCLUSION : Developments in medical metabolomics, biochemistry and deutenomics, which is the science of biological deuterium fractionation and discrimination warrant urgent critical reviews in order to control the epidemiological scale of population diseases such as diabetes, obesity and cancer by a thorough understanding of how the compromised metabolic health of grain-fed dairy cows impacts human consumers.The National Research Foundation of South Africa, the Hirshberg Foundation for Pancreatic Cancer Research, as well as the UCLA Center for Excellence in Pancreatic Diseases—Metabolomics Core.http://link.springer.com/journal/11306am2022Forestry and Agricultural Biotechnology Institute (FABI)Physic

Corpora amylacea negatively correlate with hippocampal tau pathology in Alzheimer’s disease

Introduction Severity and distribution of aggregated tau and neurofibrillary tangles (NFT) are strongly correlated with the clinical presentation of Alzheimer’s disease (AD). Clearance of aggregated tau could decrease the rate of NFT formation and delay AD onset. Recent studies implicate corpora amylacea (CA) as a regulator of onset or accumulation of tau pathology. Normally, CA clear brain waste products by amassing cellular debris, which are then extruded into the cerebrospinal fluid to be phagocytosed. The proper functioning of CA may slow progression of AD-associated NFT pathology, and this relationship may be influenced by amount and distribution of phospho-tau (pTau) produced, age, sex, and genetic risk. Objective The goal of this study was to determine if CA size and number are associated with hippocampal location and local pTau severity while accounting for variations in age, sex, and genetic risk. Methods Postmortem brain hippocampal tissue sections from 40 AD and 38 unaffected donors were immunohistochemically stained with AT8 (pTau) and counter stained with periodic acid Schiff (PAS). Stained sections of the CA1 and CA3 regions of the hippocampus were analyzed. The percent area occupied (%AO) of CA, pTau, and NFT was calculated. Pairwise comparisons and regression modeling were used to analyze the influence of age, pTau %AO, and genetic risk on %AO by CA in each region, separately in donors with AD and unaffected donors. Results CA %AO was significantly higher in the CA3 region compared to CA1 in both groups. A significant negative correlation of CA %AO with both pTau %AO and neurofibrillary tangle %AO in the CA3 region of AD brain donors was found. Regression analysis in the CA3 region revealed a significant negative association between CA with both pTau and age.ConclusionWe found an increase of CA in the CA3 region, compared to CA1 region, in AD and unaffected donors. This may suggest that the CA3 region is a hub for waste removal. Additionally, the negative correlation between %AO by CA and NFT in the CA3 region of the hippocampus in donors with AD suggests CA could play a role in AD pathologic progression by influencing tau clearance