The exported Cape Breton fiddler : a hermeneutic study of the meaning of Cape Breton fiddle music outside Cape Breton

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The physiology and biochemistry of total body immobilization in animals: A compendium of research

Major studies that describe the physiological and biochemical mechanisms which operate during total body restraint (confinement in cages for example) are presented. The metabolism and behavior of various animals used in medical research (dogs, monkeys, rats, fowl) was investigated and wherever possible a detailed annotation for each study is provided under the subheadings: (a) purposes, (b) procedures and methods, (c) results, and (d) conclusions. Selected references are also included

The Aurality of Rhetoric: A Critical Hermeneutic of Cape Breton’s Rhetorical Music Community

Although the field of rhetorical studies has expanded from the notion that rhetoric only applies to speeches, there has been little attention paid to the rhetoric of sound. This project focuses on the rhetoric of sound, specifically the musical rhetoric of the community of Cape Breton Island, in Nova Scotia, Canada. Cape Breton has a long history of maintaining a traditional music community, with its origins in Scotland. The fiddle music of Cape Breton is renowned as a genre of Celtic music. This project looks at the rhetorical acts of the musicians and investigates how these acts of vernacular rhetoric help develop the community. It shows how the individual musicians are conditioned by the history and community they are born into, but also how these same musicians affect and change that community. This cycle allows for the community’s understanding of its own musical properties and style to change through time. This project seeks to dispel the notion that the change in a community’s culture over time is the result of inevitability. Change comes from rhetorical acts by rhetorical actors. Influential musicians enter the community, and make a mark. Their influence is picked up by other musicians, who themselves add their own mark. This project focuses on the notion of judgment as the locus for this change. The Cape Breton musical community provides spaces where musicians are able to gather and publicly exercise judgment. These judgments are not guided by a blueprint of preconceived action, but rather by a practical judgment, wherein the musician holds themselves accountable to the community. As such, drawing from hermeneutical theory, this project highlights the distinction between practical judgment and technical judgment. This project is a critical one, because it seeks to raise to the forefront the prejudices that allow judgment take place, and as such it is also a hermeneutic one. The critical focus concerns the possibility that practical judgment can be dominated by technical judgment. This project stands to guard against notions of essentialism and romanticism of culture that, if given enough credence, could disrupt the possibility of practical judgment in everyday life

Physiologic responses to water immersion in man: A compendium of research

A total of 221 reports published through December 1973 in the area of physiologic responses to water immersion in man were summarized. The author's abstract or summary was used whenever possible. Otherwise, a detailed annotation was provided under the subheadings: (1) purpose, (2) procedures and methods, (3) results, and (4) conclusions. The annotations are in alphabetical order by first author; author and subject indexes are included. Additional references are provided in the selected bibliography

Adaptation to prolonged bedrest in man: A compendium of research

A compilation of major studies that describe the clinical observations and elucidate the physiological mechanisms of the adaptive process of man undergoing prolonged bed rest is presented. Additional studies are included that provide background information in the form of reviews or summaries of the process. Wherever possible a detailed annotation is provided under the subheadings: (1) purpose, (2) procedure and methods, (3) results, and (4) conclusions. Additional references are provided in a selected bibliography

Inhibition of cancer cell growth by ruthenium complexes

Background: Previous studies suggest that certain transition metal complexes, such as cisplatin, are efficacious for treating various cancer types, including ovarian, lung, and breast. Methods: In order to further evaluate ruthenium (Ru) complexes as potential anti-cancer agents, we synthesized and evaluated Ru-arene complexes. Two complexes with the general formula [Ru (n 6-p-cym) (N-N) Cl]+ were tested for their abilities to inhibit cancer cells. Results: The complex with o-phenylenediamine as the N-N ligand (o-PDA) significantly inhibited growth of breast (MDA-MB-231, MCF-7, SKBR-3, and SUM149), lymphoma (Raji), melanoma (Bowes), and osteosarcoma (HT1080); however, the complex with o-benzoquinonediimine (o-BQDI) was ineffective except for SUM149. In contrast, o-PDA failed to inhibit growth of human breast epithelial cells, MCF-10A. Treatment of MDA-MBA-231 cells with o-PDA resulted in a significant reduction of productions of PDGF-AA, GM-CSF, and VEGF-A proteins at the transcriptional levels. Finally, we demonstrated that o-PDA synergistically inhibited MDA-MB-231 cell growth with cyclophosphamide but not doxorubicin or paclitaxel. Conclusion: These results suggest that Ru-arene complexes are promising anti-cancer drugs that inhibit progression and metastasis by blocking multiple processes for breast and other types of cancer

Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth

Item does not contain fulltextThere are lines of evidence demonstrating that NEDD9 (Cas-L, HEF-1) plays a key role in the development, progression, and metastasis of breast cancer cells. We previously reported that NEDD9 plays a critical role for promoting migration and growth of MDA-MB-231. In order to further characterize the mechanisms of NEDD9-mediated cancer migration and growth, stable cells overexpressing NEDD9 were generated using HCC38 as a parental cell line which expresses low level of endogenous NEDD9. Microarray studies demonstrated that core proteins of CD44 and Serglycin were markedly upregulated in HCC38(NEDD9) cells compared to HCC38(Vector) cells, while those of Syndecan-1, Syndecan-2, and Versican were downregulated in HCC38(NEDD9). Importantly, enzymes generating chondroitin sulfate glycosaminoglycans (CS) such as CHST11, CHST15, and CSGALNACT1 were upregulated in HCC38(NEDD9) compared to HCC38(Vector). Immunofluorescence studies using specific antibody, GD3G7, confirmed the enhanced expression of CS-E subunit in HCC38(NEDD9). Immunoprecipitation and western blotting analysis demonstrated that CS-E was attached to CD44 core protein. We demonstrated that removing CS by chondroitinase ABC significantly inhibited anchorage-independent colony formation of HCC38(NEDD9) in methylcellulose. Importantly, the fact that GD3G7 significantly inhibited colony formation of HCC38(NEDD9) cells suggests that CS-E subunit plays a key role in this process. Furthermore, treatment of HCC38(NEDD9) cells with chondroitinase ABC or GD3G7 significantly inhibited mammosphere formation. Exogenous addition of CS-E enhanced colony formation and mammosphere formation of HCC38 parental and HCC38(Vector) cells. These results suggest that NEDD9 regulates the synthesis and expression of tumor associated glycocalyx structures including CS-E, which plays a key role in promoting and regulating breast cancer progression and metastasis and possibly stem cell phenotypes