Power analysis for conditional indirect effects: A tutorial for conducting Monte Carlo simulations with categorical exogenous variables

Conceptual and statistical models that include conditional indirect effects (i.e., so-called “moderated mediation” models) are increasingly popular in the behavioral sciences. Although there is ample guidance in the literature for how to specify and test such models, there is scant advice regarding how to best design studies for such purposes, and this especially includes techniques for sample size planning (i.e., “power analysis”). In this paper, we discuss challenges in sample size planning for moderated mediation models and offer a tutorial for conducting Monte Carlo simulations in the specific case where one has categorical exogenous variables. Such a scenario is commonly faced when one is considering testing conditional indirect effects in experimental research, wherein the (assumed) predictor and moderator variables are manipulated factors and the (assumed) mediator and outcome variables are observed/measured variables. To support this effort, we offer example data and reproducible R code that constitutes a “toolkit” to make up for limitations in other software and aid researchers in the design of research to test moderated mediation models

Electroproduction of the d* dibaryon

The unpolarized cross section for the electroproduction of the isoscalar $J^\pi = 3^+$ di-delta dibaryon $d^*$ is calculated for deuteron target using a simple picture of elastic electron-baryon scattering from the $\Delta \Delta (^7D_1)$ and the $NN (^3S_1)$ components of the deuteron. The calculated differential cross section at the electron lab energy of 1 GeV has the value of about 0.24 (0.05) nb/sr at the lab angle of 10$^\circ$ (30$^\circ$) for the Bonn B potential when the dibaryon mass is taken to be 2.1 GeV. The cross section decreases rapidly with increasing dibaryon mass. A large calculated width of 40 MeV for $d^*(\Delta\Delta ^7S_3)$ combined with a small experimental upper bound of 0.08 MeV for the $d^*$ decay width appears to have excluded any low-mass $d^*$ model containing a significant admixture of the $\Delta\Delta (^7S_3)$ configuration.Comment: 11 journal-style pages, 8 figure

A CsI(Tl) Scintillating Crystal Detector for the Studies of Low Energy Neutrino Interactions

Scintillating crystal detector may offer some potential advantages in the low-energy, low-background experiments. A 500 kg CsI(Tl) detector to be placed near the core of Nuclear Power Station II in Taiwan is being constructed for the studies of electron-neutrino scatterings and other keV-MeV range neutrino interactions. The motivations of this detector approach, the physics to be addressed, the basic experimental design, and the characteristic performance of prototype modules are described. The expected background channels and their experimental handles are discussed.Comment: 34 pages, 11 figures, submitted to Nucl. Instrum. Method

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes

UBVRI Light curves of 44 Type Ia supernovae

We present UBVRI photometry of 44 Type la supernovae (SNe la) observed from 1997 to 2001 as part of a continuing monitoring campaign at the Fred Lawrence Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics. The data set comprises 2190 observations and is the largest homogeneously observed and reduced sample of SNe la to date, nearly doubling the number of well-observed, nearby SNe la with published multicolor CCD light curves. The large sample of [U-band photometry is a unique addition, with important connections to SNe la observed at high redshift. The decline rate of SN la U-band light curves correlates well with the decline rate in other bands, as does the U - B color at maximum light. However, the U-band peak magnitudes show an increased dispersion relative to other bands even after accounting for extinction and decline rate, amounting to an additional ∼40% intrinsic scatter compared to the B band

Viral coinfections in hospitalized coronavirus disease 2019 patients recruited to the international severe acute respiratory and emerging infections consortium WHO clinical characterisation protocol UK study

Background We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. Methods Multiplex real-time polymerase chain reaction testing for endemic respiratory viruses was performed on upper respiratory tract samples from 1002 patients with COVID-19, aged <1 year to 102 years old, recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK study. Comprehensive demographic, clinical, and outcome data were collected prospectively up to 28 days post discharge. Results A coinfecting virus was detected in 20 (2.0%) participants. Multivariable analysis revealed no significant risk factors for coinfection, although this may be due to rarity of coinfection. Likewise, ordinal logistic regression analysis did not demonstrate a significant association between coinfection and increased disease severity. Conclusions Viral coinfection was rare among hospitalized COVID-19 patients in the United Kingdom during the first 18 months of the pandemic. With unbiased prospective sampling, we found no evidence of an association between viral coinfection and disease severity. Public health interventions disrupted normal seasonal transmission of respiratory viruses; relaxation of these measures mean it will be important to monitor the prevalence and impact of respiratory viral coinfections going forward

Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19

Background While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished COVID-19 severity categories, and relate these to disease progression and peripheral inflammation. Methods We measured 35 cytokines and chemokines in nasal samples from 274 patients hospitalised with COVID-19. Analysis considered the timing of sampling during disease, as either the early (0-5 days post-symptom onset) or late (6-20 days post-symptom onset). Results Patients that survived severe COVID-19 showed IFN-dominated mucosal immune responses (IFN-γ, CXCL10 and CXCL13) early in infection. These early mucosal responses were absent in patients that would progress to fatal disease despite equivalent SARS-CoV-2 viral load. Mucosal inflammation in later disease was dominated by IL-2, IL-10, IFN-γ, and IL-12p70, which scaled with severity but did not differentiate patients who would survive or succumb to disease. Cytokines and chemokines in the mucosa showed distinctions from responses evident in the peripheral blood, particularly during fatal disease. Conclusions Defective early mucosal anti-viral responses anticipate fatal COVID-19 but are not associated with viral load. Early mucosal immune responses may define the trajectory of severe COVID-19

Elevated-temperature (600/sup 0/F), manual contact ultrasonic examination

Manual contact ultrasonic examination at temperatures above 250/sup 0/F has not been successful in providing meaningful results. Sensitivity of standard transducers degrades rapidly at 250/sup 0/F and above. It has been demonstrated that by using standard transducers and commercially available wedges and couplants in combination with a couplant/cooler system, manual contact ultrasonic examination can be performed at 600/sup 0/F for an essentially 100% duty cycle in conformance to the sensitivity requirement of the ASME B and PV Code

Field radiography using 100 Ci of Co-60 without interrupting adjacent manufacturing operations

Radiography is the primary method of Nondestructive Examination recognized by the ASME B and PV Code as providing objective evidence of volumetric examination of the pressure boundary welds that are present in the Clinch River Breeder Reactor Program (CRBRP) Steam Generator. In order to support the steam generator production schedule, the radiographic examinations must be performed without interrupting any other manufacturing or inspection operations taking place within a 20-ft radius from the source. This condition imposes rigorous radiation safety requirements since the gamma radiation sources chosen to be used for examination of the pressure boundary welds, Co-60 and Ir-192, are very energetic. Co-60 gamma ray energy is 1.17 and 1.33 MeV and Ir-192 gamma ray is .6 MeV. The hazard of using such a high energy sources in the immediate vicinity of working personnel has necessitated the need for a thorough evaluation of methods of protection. Personnel protection from penetrating radiation, both x-ray and gamma ray, is accomplished by ingenious use, singly or in combination, of two factors which reduce radiation intensity. These factors are distance and shielding. In all radiographic operations the primary consideration is for personnel safety. The maximum radiation dose rate limit will be 0.002 rem/hr. This document describes how the factors of distance and shielding have been used to assure personnel safety at all times