High frequency large stroke design and simulation experimental research on shaking table

Firstly, this paper introduces the design of high frequency large stroke vibration table according to the applicable environment. Secondly, the three-dimensional solid model is established which is based on solidworks2012 environment. The kinematics and dynamics simulation of the shaking table model are carried out. The vibration test curve of the vibrating table is obtained, and the reason of the change of the vibration curve under different vibration frequency is analyzed. Finally, this paper concludes that this exciting scheme is feasible and effective

Green finance pilot reform and corporate green innovation

This study investigates the impact of the green finance pilot reform on corporate green innovation using the formation of the China Green Finance Pilot Reform in 2017 as a quasi-natural experiment. It shows that the green finance pilot reform increases corporate green innovation. Furthermore, by highlighting the differences between green enterprises and heavily polluting enterprises, it also shows that the positive relationship between the green finance pilot reform and corporate green innovation is more pronounced in green enterprises than in heavily polluting enterprises. The mechanism analysis shows that the green finance pilot reform mainly affects corporate green innovation by easing financing constraints and reducing financing costs. The heterogeneity analysis indicates that the positive relationship between the green finance pilot reform and corporate green innovation is more pronounced in non-state-owned enterprises and large-scale enterprises. As a result, the effect of the green finance pilot reform on corporate green innovation gives rise to certain green innovation incentives. It is thus necessary to optimise the external corporate governance environment by promoting the green finance pilot reform and further offers practical implications for corporate green innovation decision-making

Prevalence of internet addiction and its association with stressful life events and psychological symptoms among adolescent internet users

Internet addiction (IA) among adolescents is a serious public health problem around the world. However, there have been few studies that examine the association between IA and stressful life events and psychological symptoms among Chinese adolescent internet users. We examined the association between IA and stressful life events and psychological symptoms among a random sample of school students who were internet users (N = 755) in Wuhan, China. Internet addiction, stressful life events, coping style and psychological symptoms were measured by self-rated scales. The prevalence rate of internet addiction was 6.0% among adolescent internet users. Logistic regression analyses indicated that stressors from interpersonal problem and school related problem and anxiety symptoms were significantly associated with IA after controlling for demographic characteristics. Analyses examining the coping style with the IA revealed that negative coping style may mediate the effects of stressful life events to increase the risk of IA. However, no significant interaction of stressful life events and psychological symptoms was found. These findings of the current study indicate a high prevalence of internet addiction among Chinese adolescent internet users and highlight the importance of stressors from interpersonal problem and school related problem as a risk factor for IA which mainly mediated through negative coping style.Published versio

Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer

Background/Aims: Imbalance of oxidative/antioxidative enzymes in cells is associated with carcinogenesis and cancer cell chemoresistance. The aim of this study was to examine the clinical significance of potentially functional single nucleotides polymorphisms (SNPs) in antioxidative enzymes, GPxs and CAT, in stages II and III gastric cancer patients. Methods: A total of 591 gastric cancer patients who had radical gastrectomy were recruited. 207 patients received platinum and fluorouracil-based (PF-based) adjuvant chemotherapy and 384 patients were untreated. GPx1 rs1050450, GPx2 rs4902346, GPx3 rs736775, rs3828599 and CAT rs769218 were genotyped in the DNA samples extracted from paraffin-embedded tumor tissue. Results: CAT rs769218 was significantly correlated with the overall survival (OS) in the dominant model (P = 0.014). Multivariate analysis revealed that CAT rs769218 GA/AA (HR, 0.715; 95%CI, 0.562-0.910, P = 0.006) was an independent prognostic marker indicating improved survival. After adjustments, GPx3 rs736775 TC/CC was significantly associated with improved OS (HR, 0.621; 95%CI, 0.399-0.965; P=0.034) in patients treated with PF-based adjuvant chemotherapy, and CAT rs769218 GA/AA was significantly associated with improved OS (HR, 0.646; 95% CI, 0.482-0.864; P = 0.003) in the untreated patients. PF-based chemotherapy significantly decreased risk of death for patients carrying GPx3 rs736775 TC/CC and age ≤ 60 years or with diffused type adenocarcinoma compared to surgery alone. Conclusion: our findings suggested CAT rs769218 and GPx3 rs736775 may be considered as prognostic markers in gastric cancer. Patient stratification by GPx3 rs736775 and conventional pathological parameters may provide additional predictive information in treatment decision-making

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Multi-Time-Scale Coordinated Operation of a Combined System with Wind-Solar-Thermal-Hydro Power and Battery Units

The grid connection of intermittent energy sources such as wind power and photovoltaic power generation brings new challenges for the economic and safe operation of renewable power systems. To address these challenges, a multi-time-scale active power coordinated operation method, consisting of day-ahead scheduling, hour-level rolling corrective scheduling, and real-time corrective scheduling, is proposed for the combined operation of wind-photovoltaic-thermal-hydro power and battery (WPTHB) to handle renewable power fluctuations. In day-ahead scheduling, the optimal power outputs of thermal power units, hydro-pumped storage units, and batteries are solved with the purpose of minimizing the total power generation cost. In hour-level rolling corrective scheduling, the power output plan of thermal power units and pumped storage units is modified to minimize the correction cost based on the on-off state of thermal power units determined in day-ahead scheduling. In real-time corrective scheduling stage, the feedback correction and rolling optimization-based model predictive control algorithm is adopted to modify the power output of thermal power units, hydro-pumped storage units, and batteries optimized in hour-level rolling correction scheduling, so as to ensure the economy of the correction plan and the static security of system operation. Finally, simulation results demonstrated that the proposed method can accurately track system power fluctuations, and ensure the economic and security operation of a multi-energy-generation system

Analysis of laminated crack defect in the upsetting process of heavy disk-shaped forgings

Using nonlinear finite element method, a thermo-mechanical coupled simulation model for the formation mechanism of the laminated crack defect has been established in the upsetting of heavy disk-shaped forgings. Through numerical simulation, the distributions of stress, equivalent strain and strain rate were analysed. Meanwhile the distribution diagram of stress state evolution was obtained, and the uncoordinated deformation, under tri-lateral compression, is determined as the main reason leading to laminated crack defect. To reveal the characteristics of the uncoordinated deformation, the variations of each variable and its gradient in numerical simulation were presented, and a combined prediction model of laminated crack defect were proposed based on degree of deformation and gradient of deformation speed. Subsequently, the morphology and distribution of laminated crack were obtained in the centre of forging using the prediction model. Comparison of calculation results and experimental data indicates that both of them match well. In addition, the effect of friction coefficient on the deformation is also presented. The results show that the decreasing of friction coefficient is an effective measure to restrain the laminated crack defect