Geodynamics in spacetime crystal under slow perturbation and deformation

We present a theory of geodynamics in a spacetime crystal based on an event wavepacket constructed from the Floquet-Bloch waves, which not only involve a scalar dispersion function but also a Berry curvature tensor in the phase space manifold of spacetime and the reciprocal quasi energy-momentum. In the presence of structural deformation, this theory is naturally extended into a covariant form with the introduction of a lattice connection constructed out of the gradients of the local lattice vectors. The geodesic equation for a free particle involves not only the lattice connection but also higher-order corrections from spacetime inhomogeneity of Berry curvatures and quasi energy-momentum dispersion

Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma

Invasion, metastasis and resistance to conventional chemotherapeutic agents are obstacles to successful treatment of pancreatic cancer, and a better understanding of the molecular basis of this malignancy may lead to improved therapeutics. In the present study, we investigated whether AKT2 silencing sensitized pancreatic cancer L3.6pl, BxPC-3, PANC-1 and MIAPaCa-2 cells to gemcitabine via regulating PUMA (p53-upregulated modulator of apoptosis) and nuclear factor (NF)-κB signaling pathway. MTT, TUNEL, EMSA and NF-κB reporter assays were used to detect tumor cell proliferation, apoptosis and NF-κB activity. Western blotting was used to detect different protein levels. Xenograft of established tumors was used to evaluate primary tumor growth and apoptosis after treatment with gemcitabine alone or in combination with AKT2 siRNA. Gemcitabine activated AKT2 and NF-κB in MIAPaCa-2 and L3.6pl cells in vitro or in vivo, and in PANC-1 cells only in vivo. Gemcitabine only activated NF-κB in BxPC-3 cells in vitro. The presence of PUMA was necessary for gemcitabine-induced apoptosis only in BxPC-3 cells in vitro. AKT2 inhibition sensitized gemcitabine-induced apoptosis via PUMA upregulation in MIAPaCa-2 cells in vitro, and via NF-κB activity inhibition in L3.6pl cells in vitro. In PANC-1 and MIAPaCa-2 cells in vivo, AKT2 inhibition sensitized gemcitabine-induced apoptosis and growth inhibition via both PUMA upregulation and NF-κB inhibition. We suggest that AKT2 inhibition abrogates gemcitabine-induced activation of AKT2 and NF-κB, and promotes gemcitabine-induced PUMA upregulation, resulting in chemosensitization of pancreatic tumors to gemcitabine, which is probably an important strategy for the treatment of pancreatic cancer

Middle-Late Jurassic magmatism in the west central Lhasa subterrane, Tibet: Petrology, zircon chronology, elemental and Sr-Nd-Pb-Hf-Mg isotopic geochemistry

Mesozoic magmatic rocks are widespread in the Lhasa terrane, but most of them are of cretaceous age. Because Jurassic rocks are relatively rare and our knowledge on such earlier magmatism in the context of the tectonic setting and evolution is limited. In this study, we focus on the mid-late Jurassic granitoids that occur in the west central Lhasa subterrane. We present the results of a systematic study of these granitoid rocks of tonalite composition together with the hosted mafic magmatic enclaves. We dated 4 representative tonalite samples and 2 enclaves using zircon U-Pb method that gives the age range of 167–154 Ma. All these samples have Sr-Nd-Pb isotopic compositions (87Sr/86Sr = 0.713941–0.718417, εNd(t) = −14 to −9.8, 206Pb/204Pb = 18.806–18.936, 207Pb/204Pb = 15.739–15.764, 208Pb/204Pb = 39.257–39.798) similar to the composition of gneisses from the basement of the Lhasa terrane, suggesting that magmas parental to these mid-late Jurassic granitoids of tonalitic composition are of largely crustal origin, which is also supported by the petrographic observations. Both of the tonalite samples and the mafic enclaves have a wide span of zircon εHf(t) of −15.9 to −0.2 and − 13.8 to −7.4, respectively. These samples also show varying δ26Mg ranging from −0.40 to −0.18, with an average δ26Mg = −0.27 ± 0.06‰ (2SD) that is best understood as representing the Mg composition of the continental crust of the Lhasa terrane. All these observations allow us to conclude that basaltic melts derived from metasomatized mantle were involved in the petrogenesis of these granitoids. Specifically, southward subduction of the Bangong-Nujiang Ocean lithosphere and subsequent slab rollback metasomatized the mantle wedge and the lithospheric mantle above, whose melting produced basaltic magmas. Underplating and intrusion of these basaltic magmas caused crustal melting and generation of granitoid magmas parental to the tonalite and enclaves we study

QCD sum rule studies on the sssˉsˉs s \bar s \bar s tetraquark states of JPC=0−+J^{PC} = 0^{-+}

We apply the method of QCD sum rules to study the $s s \bar s \bar s$ tetraquark states of $J^{PC} = 0^{-+}$. We construct all the relevant $s s \bar s \bar s$ tetraquark currents, and find that there are only two independent ones. We use them to further construct two weakly-correlated mixed currents. One of them leads to reliable QCD sum rule results and the mass is extracted to be $2.51^{+0.15}_{-0.12}$ GeV, suggesting that the $X(2370)$ or the $X(2500)$ can be explained as the $ss\bar s\bar s$ tetraquark state of $J^{PC} = 0^{-+}$. To verify this interpretation, we propose to further study the $\pi\pi/K \bar K$ invariant mass spectra of the $J/\psi \to \gamma \pi \pi \eta^\prime/\gamma K \bar K \eta^\prime$ decays in BESIII to examine whether there exists the $f_0(980)$ resonance.Comment: 8 pages, 6 figures, suggestions and comments are welcom

Wireless Deep Video Semantic Transmission

In this paper, we design a new class of high-efficiency deep joint source-channel coding methods to achieve end-to-end video transmission over wireless channels. The proposed methods exploit nonlinear transform and conditional coding architecture to adaptively extract semantic features across video frames, and transmit semantic feature domain representations over wireless channels via deep joint source-channel coding. Our framework is collected under the name deep video semantic transmission (DVST). In particular, benefiting from the strong temporal prior provided by the feature domain context, the learned nonlinear transform function becomes temporally adaptive, resulting in a richer and more accurate entropy model guiding the transmission of current frame. Accordingly, a novel rate adaptive transmission mechanism is developed to customize deep joint source-channel coding for video sources. It learns to allocate the limited channel bandwidth within and among video frames to maximize the overall transmission performance. The whole DVST design is formulated as an optimization problem whose goal is to minimize the end-to-end transmission rate-distortion performance under perceptual quality metrics or machine vision task performance metrics. Across standard video source test sequences and various communication scenarios, experiments show that our DVST can generally surpass traditional wireless video coded transmission schemes. The proposed DVST framework can well support future semantic communications due to its video content-aware and machine vision task integration abilities.Comment: published in IEEE JSA

QCD sum rule study on the fully strange tetraquark states of JPC = 2++

We apply the QCD sum rule method to systematically study the fully strange tetraquark states with the quantum number JPC = 2++. We construct both the diquark–antidiquark and mesonic–mesonic currents and calculate both their diagonal and off-diagonal correlation functions. Based on the obtained results, we further construct three mixing currents that are nearly non-correlated. We use one mixing current to extract the mass of the lowest-lying state to be 2.03−0.15+0.16 GeV, which can be used to explain f2(2010) as a fully strange tetraquark state of JPC = 2++. This state was observed by BESIII in the ϕϕ channel, and we propose to confirm it in the η(′)η(′) channel

Host Phylogeny Is a Major Determinant of Fagaceae-Associated Ectomycorrhizal Fungal Community Assembly at a Regional Scale

Environmental filtering (niche process) and dispersal limitation (neutral process) are two of the primary forces driving community assembly in ecosystems, but how these processes affect the Fagaceae-associated ectomycorrhizal (EM) fungal community at regional scales is so far poorly documented. We examined the EM fungal communities of 61 plant species in six genera belonging to the Fagaceae distributed across Chinese forest ecosystems (geographic distance up to ∼3,757 km) using Illumina Miseq sequencing of ITS2 sequences. The relative effects of environmental filtering (e.g., host plant phylogeny, soil and climate) and dispersal limitation (e.g., spatial distance) on the EM fungal community were distinguished using multiple models. In total, 2,706 operational taxonomic units (OTUs) of EM fungi, corresponding to 54 fungal lineages, were recovered at a 97% sequence similarity level. The EM fungal OTU richness was significantly affected by soil pH and nutrients and by host phylogeny. The EM fungal community composition was significantly influenced by combinations of host phylogeny, spatial distance, soil and climate. Furthermore, host phylogeny had the greatest effect on EM fungal community. The study suggests that the assembly of the EM fungal community is governed by both environmental filtering and dispersal limitation, with host effect being the most important determinant at the regional scale