Active Disturbance Rejection Control for MEMS Gyroscopes

A new control method is presented to drive the drive axis of a Micro-Electro-Mechanical Systems (MEMS) gyroscope to resonance and to regulate the output amplitude of the axis to a fixed level. It is based on a unique active disturbance rejection control (ADRC) strategy, which actively estimates and compensates for internal dynamic changes of the drive axis and external disturbances in real time. The stability analysis shows that both the estimation error and the tracking error of the drive axis output are bounded and that the upper bounds of the errors monotonously decrease with the increase of the controller bandwidth. The control system is simulated and tested using a field-programmable-gate-array-based digital implementation on a piezoelectric vibrational gyroscope. Both simulation and experimental results demonstrate that the proposed controller not only drives the drive axis to vibrate along the desired trajectory but also compensates for manufacture imperfections in a robust fashion that makes the performance of the gyroscope insensitive to parameter variations and noises. Such robustness, the fact that the control design does not require an accurate plant model, and the ease of implementation make the proposed solution practical and economic for industrial applications

Reputation, Academic Experience, and Collaboration Returns from International Co-authorships

In recent years, the phenomenon of international co-authorships from emerging economies, especially Chinese scholars' academic collaborations, has become the focus of academic attention. Based on resource-based theory, taking the native scholars from mainland China with international co-authorships in 39 leading management journals as the sample, the article investigates the influence of individual scholars’ reputation and academic experience on their international collaboration returns. The empirical results show that, (1) Chinese native scholars could receive positive collaboration returns from international co-authorships; (2)the impact of academic experience of native scholars on collaboration returns depends on the measurement of “experience”. Early publishing experience in international journals positively influence collaboration returns, while the number of articles published in international journal does not have significant impact on collaboration returns. Keywords: Chinese native scholars, Collaboration returns from international co-authorships, Resources-based theory, Reputation, Academic experienc

Kinetics of cytokine expression in cirrhotic rats

AbstractBackgroundCytokines are involved in liver injury and cirrhosis and systemic and hepatic cytokine levels may help predict cirrhosis evolution. However, the relevant survey has not been performed.MethodsMale Sprague-Dawley rats (240–270g) received either common bile duct ligation (BDL, animal model of cholestatic liver injury) or sham operation (control). Five rats were sacrificed and liver and serum were collected from each in weeks 1, 2, 4, 6, 8 and 10 after surgery. Hepatic expression of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) were analyzed by immunohistochemial staining. The corresponding serum levels were measured by ELISA.ResultsCompared to the corresponding sham groups, hepatic expression of these cytokines in BDL rats was significantly and progressively enhanced during cirrhosis development. However, serum IFN-γ levels of BDL rats did not change significantly. Serum TNF-α of BDL rats increased gradually and reached a peak in week 6. Serum TGF-β level was elevated up to week 8, whereas IL-10 level decreased progressively until week 6.ConclusionCirrhosis development in BDL rats is associated with progressively enhanced expression of hepatic pro-inflammatory and anti-inflammatory cytokines, which is not in accord with the corresponding serum concentration. The circulating cytokine concentration may not totally reflect the hepatic expression level throughout the development of cirrhosis

Identification of H3K4me1-associated proteins at mammalian enhancers.

Enhancers act to regulate cell-type-specific gene expression by facilitating the transcription of target genes. In mammalian cells, active or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a cell-type-specific manner. Whether and how this histone modification regulates enhancer-dependent transcription programs in mammals is unclear. In this study, we conducted SILAC mass spectrometry experiments with mononucleosomes and identified multiple H3K4me1-associated proteins, including many involved in chromatin remodeling. We demonstrate that H3K4me1 augments association of the chromatin-remodeling complex BAF to enhancers in vivo and that, in vitro, H3K4me1-marked nucleosomes are more efficiently remodeled by the BAF complex. Crystal structures of the BAF component BAF45C indicate that monomethylation, but not trimethylation, is accommodated by BAF45C's H3K4-binding site. Our results suggest that H3K4me1 has an active role at enhancers by facilitating binding of the BAF complex and possibly other chromatin regulators

Analysis of the Optimal Frequency Band for a Ballistic Missile Defense Radar System

In this paper, we consider the anti-attack procedure of a ballistic missile defense system (BMDS) at different operating frequencies at its phased-array radar station. The interception performance is measured in terms of lateral divert (LD), which denotes the minimum acceleration amount available in an interceptor to compensate for prediction error for a successful intercept. Dependence of the frequency on estimation accuracy that leads directly to prediction error is taken into account, in terms of angular measurement noises. The estimation extraction is performed by means of an extended Kalman filter (EKF), considering two typical re-entry trajectories of a non-maneuvering ballistic missile (BM). The simulation results show better performance at higher frequency for both tracking and intercepting aspects