Solvable Potentials from Supersymmetric Quantum Mechanics

A recurrence relation of Riccati-type differential equations known in supersymmetric quantum mechanics is investigated to find exactly solvable potentials. Taking some simple {\it ans\"atze}, we find new classes of solvable potentials as well as reproducing the known shape-invariant ones.Comment: 14 pages, Late

Penetration of UVA into water and its effects on primary productivity with special reference to water column mixing

Article信州大学理学部附属諏訪臨湖実験所報告 9: 1-11(1995)departmental bulletin pape

The economic explainability of machine learning and standard econometric models-an application to the U.S. mortgage default risk

This study aims to bridge the gap between two perspectives of explainability−machine learning and engineering, and economics and standard econometrics−by applying three marginal measurements. The existing real estate literature has primarily used econometric models to analyze the factors that affect the default risk of mortgage loans. However, in this study, we estimate a default risk model using a machine learning-based approach with the help of a U.S. securitized mortgage loan database. Moreover, we compare the economic explainability of the models by calculating the marginal effect and marginal importance of individual risk factors using both econometric and machine learning approaches. Machine learning-based models are quite effective in terms of predictive power; however, the general perception is that they do not efficiently explain the causal relationships within them. This study utilizes the concepts of marginal effects and marginal importance to compare the explanatory power of individual input variables in various models. This can simultaneously help improve the explainability of machine learning techniques and enhance the performance of standard econometric methods

Eutrophication and the primary productivity of phytoplankton in Lake Soyang, Korea.

Article信州大学理学部附属諏訪臨湖実験所報告 9: 155-159(1995)departmental bulletin pape

PRIMARY PRODUCTION OF PHYTOPLANKTON AND MACROPHYTES IN AN EUTROPHIC LAGOON, LAKE KYUNGPO, KOREA

Primary production of phytoplankton and macrophytes are measured in a eutrophic lagoon, Lake Kyungpo, where 86% of the lake is inhabited by macrophytes. Phytoplankton standing crop was high, 40-130 mgChl/m³, but productivity per unit area was suppressed low by the light deficiency due to high content of inorganic suspended particles. Contribution of phytoplankton and macrophytes to the total annual production was 55% and 45%, respectively. Allochthonous organic input estimated from BOD was 36% of total organic matter supply. Nitrogen seems to be the limiting nutrient for phytoplankton, since nitrate is often depleted in the water column of macrophyte-growing region and N/P ratio is low. Turbulence and the vertical transfer of oxygen and nutrient are strongly suppressed by the dense population of macrophytes and the chemocline of high stability caused by saline bottom water.Article信州大学理学部付属諏訪臨湖実験所報告 7: 99-103(1991)departmental bulletin pape

EUTROPHICATION OF THE MAJOR RESERVOIRS IN KOREA

Trophic state of several major reservoirs in Korea are reviewed. Most of large reservoirs are mesotrophic to eutrophic, suffering bluegreen algal blooms. Recently many reservoirs are being eutrophied at high rate mainly due to the increase of excretion by livestock in watershed and netcage-type fishfarms within the lake basins. The trophic state changes of Lake Soyang, from oligotrophy to eutrophy in recent 10 years, are presented as a case study of rapid eutrophication. Chlorophyll a concentration increased from ca. 3mg/m³ in early 1980s to 15 mg/m³ in 1989. The dominant phytoplankton species in summer are changed from Peridinium to Anabaena since 1986 and the standing crop of Anabaena has been increasing. Secchidisc depth decreased from 5 to 1m. TP increased from 7 to 20 mgP/m³. The rate of hypolimnetic oxygen deficit increased year to year from 0.028 mgO₂/cm²/day in 1986 to 0.094 in 1989. Fishfarms within the lake are the major phosphorus source in Lake Soyang exceeding the total phosphorus loading from the watershed. This high rate of eutrophication is expected to persist in next decade.Article信州大学理学部付属諏訪臨湖実験所報告 7: 21-29(1991)departmental bulletin pape

Real-time bladder volume monitoring by the application of a new implantable bladder volume sensor for a small animal model

AbstractAlthough real-time monitoring of bladder volume together with intravesical pressure can provide more information for understanding the functional changes of the urinary bladder, it still entails difficulties in the accurate prediction of real-time bladder volume in urodynamic studies with small animal models. We studied a new implantable bladder volume monitoring device with eight rats. During cystometry, microelectrodes prepared by the microelectromechanical systems process were placed symmetrically on both lateral walls of the bladder, and the expanded bladder volume was calculated. Immunohistological study was done after 1 week and after 4 weeks to evaluate the biocompatibility of the microelectrode. From the point that infused saline volume into the bladder was higher than 0.6mL, estimated bladder volume was statistically correlated with the volume of saline injected (p<0.01). Additionally, the microelectromechanical system microelectrodes used in this study showed reliable biocompatibility. Therefore, the device can be used to evaluate changes in bladder volume in studies with small animals, and it may help to provide more information about functional changes in the bladder in laboratory studies. Furthermore, owing to its biocompatibility, the device could be chronically implanted in conscious ambulating animals, thus allowing a novel longitudinal study to be performed for a specific purpose

Association between childhood adversities and adulthood depressive symptoms in South Korea: Results from a nationally representative longitudinal study

Objective To examine how childhood adversity (ie, parental death, parental divorce, suspension of school education due to financial strain or being raised in a relative\u27s house due to financial strain) is associated with prevalence and incidence of adulthood depressive symptoms and whether this association differs by gender and by age in South Korea. Design Prospective cohort design. Setting Nationally representative longitudinal survey in South Korea. Participants 11 526 participants in South Korea. Outcome measure Prevalence and incidence of adulthood depressive symptoms were assessed as a dichotomous variable using the Centers for Epidemiologic Studies Depression (CES-D) Scale in 2006 and 2007. Results In the prevalence analysis, each of the four childhood adversities was significantly associated with a higher prevalence of adulthood depressive symptoms. The higher incidence of depressive symptoms was associated with suspension of school education (OR 1.55, 95% CI 1.32 to 1.82) and parental divorce (OR 1.65, 95% CI 1.00 to 2.71). In the age-stratified analyses, prevalence of depressive symptoms was associated with all CAs across different adulthoods, except for parental divorce and late adulthood depressive symptoms. After being stratified by gender, the association was significant for parental divorce (OR 3.76, 95% CI 2.34 to 6.03) in the prevalence analysis and for being raised in a relative’s house (OR 1.89, 95% CI 1.21 to 2.94) in the incidence analysis only among women. Conclusions This study suggests that childhood adversity may increase prevalence and incidence of adulthood depressive symptoms, and the impact of parental divorce or being raised in a relative\u27s house due to financial strain on adulthood depressive symptoms may differ by gender

Recombinant uteroglobin prevents the experimental crescentic glomerulonephritis

Recombinant uteroglobin prevents the experimental crescentic glomerulonephritis.BackgroundAlthough uteroglobin is known to have an immunomodulatory property and prevents the deposition of immune-complexes on the glomeruli of mice, the therapeutic potential of uteroglobin is uncertain in glomerulonephritis. To test the hypothesis that uteroglobin can prevent glomerulonephritis, we have studied the effects of recombinant uteroglobin on the development of experimental crescentic glomerulonephritis that is induced by anti-glomerular basement membrane (anti-GBM) antibodies.Methods and ResultsGlomerulonephritis was induced by the intravenous injection of rabbit anti-GBM globulin antibodies into mice (C57BL/6), and renal injury was evaluated 7, 14, and 21 days afterward. Recombinant uteroglobin or phosphate-buffered saline (PBS) were given intravenously to mice for 3 days after anti-GBM antibody injection. Proteinuria was significantly reduced in mice treated with recombinant uteroglobin compared with disease-control mice at 7 and 14 days after an anti-GBM antibody injection, although the serum creatinine concentration was similar in both groups. The amount of proteinuria was similar in recombinant uteroglobin-treated and normal control mice. By histologic analysis, mesangial matrix expansion, mesangial proliferation, and cellular crescents representing crescentic glomerulonephritis were markedly attenuated by injection of recombinant uteroglobin. The in vitro proliferative responses of mesangial cells to lipopolysaccharide (LPS) were blunted by the addition of recombinant uteroglobin in a dose-dependent manner. The preventive effects exerted by recombinant uteroglobin treatment were based on the inhibition of antibodies and complement-3 deposition on the glomeruli.ConclusionThis study demonstrates the preventive effects of recombinant uteroglobin in an experimental model of crescentic glomerulonephritis, and suggests the therapeutic implications of uteroglobin for human chronic glomerulonephritis

Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells

Agaricus blazei is widely accepted as a traditional medicinal mushroom, and it has been known to exhibit immunostimulatory and anti-cancer activity. However, the apoptotic mechanism in cancer cells is poorly understood. In this study, we have investigated whether A. blazei extract (ABE) exerts antiproliferative and apoptotic effects in human leukemic THP-1 cells. We observed that ABE-induced apoptosis is associated with the mitochondrial pathway, which is mediated by reactive oxygen species (ROS) generation and prolonged c-Jun N-terminal kinase (JNK) activation. In addition, the ABE treatment resulted in the accumulation of cytochrome c in the cytoplasm, an increase in caspase activity, and an upregulation of Bax and Bad. With those results in mind, we found that ABE decreases constitutive NF-κB activation and NF-κB-regulated gene products such as IAP-1 and -2. We concluded that ABE induces apoptosis with ROS-dependent JNK activation and constitutive activated NF-κB inhibition in THP-1 cells