1,615 research outputs found
Expression of stm4467-encoded arginine deiminase controlled by the stm4463 regulator contributes to salmonella enterica serovar typhimurium virulence
Arginine deiminase (ADI), carbamate kinase (CK), and ornithine transcarbamoylase (OTC) constitute the ADI system. In addition to metabolic functions, the ADI system has been implicated in the virulence of certain pathogens. The pathogenic intracellular bacterium Salmonella enterica serovar Typhimurium possesses the STM4467, STM4466, and STM4465 genes, which are predicted to encode ADI, CK, and OTC, respectively. Here we report that the STM4467 gene encodes an ADI and that ADI activity plays a role in the successful infection of a mammalian host by S. Typhimurium. An STM4467 deletion mutant was defective for replication inside murine macrophages and was attenuated for virulence in mice. We determined that a regulatory protein encoded by the STM4463 gene functions as an activator for STM4467 expression. The expression of the ADI pathway genes was enhanced inside macrophages in a process that required STM4463. Lack of STM4463 impaired the ability of S. Typhimurium to replicate within macrophages. A mutant defective in STM4467-encoded ADI displayed normal production of nitric oxide by macrophages
Satellite Clustering for Non-Terrestrial Networks: Concept, Architectures, and Applications
Recently, mega-constellations with a massive number of low Earth orbit (LEO)
satellites are being considered as a possible solution for providing global
coverage due to relatively low latency and high throughput compared to
geosynchronous orbit satellites. However, as the number of satellites and
operators participating in the LEO constellation increases, inter-satellite
interference will become more severe, which may yield marginal improvement or
even decrement in network throughput. In this article, we introduce the concept
of satellite clusters that can enhance network performance through satellites'
cooperative transmissions. The characteristics, formation types, and
transmission schemes for the satellite clusters are highlighted. Simulation
results evaluate the impact of clustering from coverage and capacity
perspectives, showing that when the number of satellites is large, the
performance of clustered networks outperforms the unclustered ones. The viable
network architectures of the satellite cluster are proposed based on the 3GPP
standard. Finally, the future applications of clustered satellite networks are
discussed.Comment: 7 pages, 7 figures, 1 table, submitted to IEEE Vehicular Technology
Magazin
A new cognition-based chat system for avatar agents in virtual space
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A Planetary lensing feature in caustic-crossing high-magnification microlensing events
Current microlensing follow-up observations focus on high-magnification
events because of the high efficiency of planet detection. However, central
perturbations of high-magnification events caused by a planet can also be
produced by a very close or a very wide binary companion, and the two kinds of
central perturbations are not generally distinguished without time consuming
detailed modeling (a planet-binary degeneracy). Hence, it is important to
resolve the planet-binary degeneracy that occurs in high-magnification events.
In this paper, we investigate caustic-crossing high-magnification events caused
by a planet and a wide binary companion. From this study, we find that because
of the different magnification excess patterns inside the central caustics
induced by the planet and the binary companion, the light curves of the
caustic-crossing planetary-lensing events exhibit a feature that is
discriminated from those of the caustic-crossing binary-lensing events, and the
feature can be used to immediately distinguish between the planetary and binary
companions. The planetary-lensing feature appears in the interpeak region
between the two peaks of the caustic-crossings. The structure of the interpeak
region for the planetary-lensing events is smooth and convex or boxy, whereas
the structure for the binary-lensing events is smooth and concave. We also
investigate the effect of a finite background source star on the
planetary-lensing feature in the caustic-crossing high-magnification events.
From this, we find that the convex-shaped interpeak structure appears in a
certain range that changes with the mass ratio of the planet to the
planet-hosting star.Comment: 14 pages, 4 figures. Accepted for publication in Ap
Gold Nanoparticles for Photothermal Cancer Therapy
Gold is a multifunctional material that has been utilized in medicinal applications for centuries because it has been recognized for its bacteriostatic, anticorrosive, and antioxidative properties. Modern medicine makes routine, conventional use of gold and has even developed more advanced applications by taking advantage of its ability to be manufactured at the nanoscale and functionalized because of the presence of thiol and amine groups, allowing for the conjugation of various functional groups such as targeted antibodies or drug products. It has been shown that colloidal gold exhibits localized plasmon surface resonance (LPSR), meaning that gold nanoparticles can absorb light at specific wavelengths, resulting in photoacoustic and photothermal properties, making them potentially useful for hyperthermic cancer treatments and medical imaging applications. Modifying gold nanoparticle shape and size can change their LPSR photochemical activities, thereby also altering their photothermal and photoacoustic properties, allowing for the utilization of different wavelengths of light, such as light in the near-infrared spectrum. By manufacturing gold in a nanoscale format, it is possible to passively distribute the material through the body, where it can localize in tumors (which are characterized by leaky blood vessels) and be safely excreted through the urinary system. In this paper, we give a quick review of the structure, applications, recent advancements, and potential future directions for the utilization of gold nanoparticles in cancer therapeutics
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